Title:
NOVEL 3-SUBSTITUTED 1,2,4-BENZOTRIAZINES, A METHOD FOR THEIR PRODUCTION AND THE USE THEREOF FOR THE TREATMENT AND PROPHYLAXIS OF TUMOURS
Document Type and Number:
WIPO Patent Application WO2001046162
Kind Code:
A3
Abstract:
The invention relates to novel 3-substituted 1,2,4-benzotriazines of the general formula I. In said formula, R<1> represents a straight-chain or branched, saturated, or mono or polyunsaturated, unsubstituted hydrocarbon group with 1 to 22 atoms, or a hydrocarbon group with 1 to 22 atoms, substituted once or several times by halogen, oxygen, hydroxy, amino, alkoxy, alkoxycarbonyl, morpholino and/or alkyl amino, or an unsubstituted or substituted aryl group or a heterocyclic group. R<2>. R<3>, R<4> and R<5> are identical or represent independently of one another hydrogen, halogen, NO2, NH2, OH or an alkoxy or alkyl group with 1-6 atoms. The invention also relates to a method for producing said 3-substituted 1,2,4-benzotriazines and to the use thereof for treating tumours.
Inventors:
STOTTMEISTER ULRICH (DE)
SCHOENFELDER MANFRED (DE)
WILDE HORST (DE)
SICKER DIETER (DE)
ANDERSCH JENS (DE)
SCHOENFELDER MANFRED (DE)
WILDE HORST (DE)
SICKER DIETER (DE)
ANDERSCH JENS (DE)
Application Number:
PCT/EP2000/013028
Publication Date:
April 18, 2002
Filing Date:
December 20, 2000
Export Citation:
Assignee:
UFZ LEIPZIGHALLE GMBH (DE)
STOTTMEISTER ULRICH (DE)
SCHOENFELDER MANFRED (DE)
WILDE HORST (DE)
SICKER DIETER (DE)
ANDERSCH JENS (DE)
STOTTMEISTER ULRICH (DE)
SCHOENFELDER MANFRED (DE)
WILDE HORST (DE)
SICKER DIETER (DE)
ANDERSCH JENS (DE)
International Classes:
A61P35/00; C07D253/10; (IPC1-7): C07D253/08; A61K31/53; A61P35/00
Foreign References:
| EP0649658A1 | 1995-04-26 | |||
| DD150463A1 | 1981-09-02 | |||
| DD278791A1 | 1990-05-16 |
Other References:
REICH M F ET AL: "Pyrido[3,4-e]-1,2,4-triazines and Related Heterocycles as Pontential Antifungal Agents", JOURNAL OF MEDICINAL CHEMISTRY., vol. 32, no. 11, 1989, pages 2474 - 2485, XP002167214, ISSN: 0022-2623
DATABASE XFIRE Beilstein Informationsysteme GmbH, Frankfurt, DE; XP002167215
DATABASE XFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002167216
DATABASE XFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002167217
HENRIE R N, II ET AL: "Discovery and optimization of a PSI electron-accepting 1,2,4-benzotriazine herbicide", QUANT. STRUCT.-ACT. RELAT., vol. 12, no. 1, 1993, pages 27 - 37, XP000996799
DATABASE XFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002167218
ANDERSCH J ET AL: "Reductive cyclization of carbohydrate 2-nitrophenylhydrazones to chiral functionalized 1,2,4-benzotriazines and benzimidazoles", J. HETEROCYCL. CHEM., vol. 36, no. 3, 1999, pages 589 - 594, XP000999073
DATABASE XFIRE Beilstein Informationsysteme GmbH, Frankfurt, DE; XP002167215
DATABASE XFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002167216
DATABASE XFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002167217
HENRIE R N, II ET AL: "Discovery and optimization of a PSI electron-accepting 1,2,4-benzotriazine herbicide", QUANT. STRUCT.-ACT. RELAT., vol. 12, no. 1, 1993, pages 27 - 37, XP000996799
DATABASE XFIRE Beilstein Informationssysteme GmbH, Frankfurt, DE; XP002167218
ANDERSCH J ET AL: "Reductive cyclization of carbohydrate 2-nitrophenylhydrazones to chiral functionalized 1,2,4-benzotriazines and benzimidazoles", J. HETEROCYCL. CHEM., vol. 36, no. 3, 1999, pages 589 - 594, XP000999073
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