Title:
NOVEL ANTIBIOTICS, BISPOLIDES A1, A2 AND A3 AND BISPOLIDES B1, B2a, B2b AND B3 AND METHOD FOR PRODUCING THE ANTIBIOTICS
Document Type and Number:
WIPO Patent Application WO/2007/132937
Kind Code:
A1
Abstract:
Seven kinds of novel antibiotics could be produced by culturing a strain named
Microbispora sp. A34030 strain (deposited under the accession number of FERM
BP-10505 under Budapest Treaty) which had been isolated from a soil sample. The
seven kinds of antibiotics were named bispolide A1, bispolide A2 bispolide A3,
bispolide B1, bispolide B2a, bispolide B2b and bispolide B3, respectively.
The bispolides are novel compounds generally having a chemical structure represented
by the general formula (III), and because they have an excellent antibacterial
activity against various bacteria, particularly Gram-positive bacteria and
antibiotic-resistant strains thereof, it is useful for the treatment of a Gram-positive
bacterial infection in a human or an animal. General formula (III):
Inventors:
NUMATA KEIICHI (JP)
OKUJO NORIYUKI (JP)
KHOR SIEW EIM (MY)
TAN LEE LI (MY)
GEORGE ANNIE (MY)
NG SZU TING (MY)
TAN CHIN JYE (MY)
IINUMA HIRONOBU (JP)
FUKAGAWA YASUO (JP)
HOTTA KUNIMOTO (JP)
SHIBAHARA SEIJI (JP)
KONDO SHINICHI (JP)
NIMURA SATOSHI (JP)
OKUJO NORIYUKI (JP)
KHOR SIEW EIM (MY)
TAN LEE LI (MY)
GEORGE ANNIE (MY)
NG SZU TING (MY)
TAN CHIN JYE (MY)
IINUMA HIRONOBU (JP)
FUKAGAWA YASUO (JP)
HOTTA KUNIMOTO (JP)
SHIBAHARA SEIJI (JP)
KONDO SHINICHI (JP)
NIMURA SATOSHI (JP)
Application Number:
PCT/JP2007/060304
Publication Date:
November 22, 2007
Filing Date:
May 15, 2007
Export Citation:
Assignee:
NIMURA GENETIC SOLUTIONS CO LT (JP)
FOREST RES INST MALAYSIA (MY)
NUMATA KEIICHI (JP)
OKUJO NORIYUKI (JP)
KHOR SIEW EIM (MY)
TAN LEE LI (MY)
GEORGE ANNIE (MY)
NG SZU TING (MY)
TAN CHIN JYE (MY)
IINUMA HIRONOBU (JP)
FUKAGAWA YASUO (JP)
HOTTA KUNIMOTO (JP)
SHIBAHARA SEIJI (JP)
KONDO SHINICHI (JP)
NIMURA SATOSHI (JP)
FOREST RES INST MALAYSIA (MY)
NUMATA KEIICHI (JP)
OKUJO NORIYUKI (JP)
KHOR SIEW EIM (MY)
TAN LEE LI (MY)
GEORGE ANNIE (MY)
NG SZU TING (MY)
TAN CHIN JYE (MY)
IINUMA HIRONOBU (JP)
FUKAGAWA YASUO (JP)
HOTTA KUNIMOTO (JP)
SHIBAHARA SEIJI (JP)
KONDO SHINICHI (JP)
NIMURA SATOSHI (JP)
International Classes:
C12P7/02; A61K31/04; A61K31/7048; C07H17/04; C12P7/62; C12P17/14; C12P19/44
Foreign References:
| JPH11113588A | 1999-04-27 | |||
| EP0297523A2 | 1989-01-04 | |||
| EP0315003A2 | 1989-05-10 | |||
| DE3248280A1 | 1984-07-05 |
Other References:
KIYOTA K.: "Shinki Kosei Busshitsu Biospolide no Hakken ni Tsuite", 15 May 2006 (2006-05-15), XP003019321, Retrieved from the Internet
IGARASHI Y. ET AL.: "Glucosylquestiomycin, a novel antibiotic from Microbispora sp. TP-A0184: fermentation, isolation, structure determination, synthesis and biological activities", THE JOURNAL OF ANTIBIOTICS, vol. 51, no. 10, 1998, pages 915 - 920, XP003019322
NAKAJIMA Y. ET AL.: "Microbispora corallina sp. nov., a new species of the genus Microbispora isolated from Thai soil", INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, vol. 49, no. 4, 1999, pages 1761 - 1767, XP003019323
OKUJO N. ET AL.: "Bispolides, novel 20-membered ring macrodiolide antibiotics from microbispora", THE JOURNAL OF ANTIBIOTICS, vol. 60, no. 3, 25 March 2007 (2007-03-25), pages 216 - 219, XP003019324
ARCAMONE, F. M. ET AL., MICROBIOL., vol. 7, 1959, pages 207
ARAI, M, "ANTIBIOT." SER. A, 1960, pages 13
KHLEBAROVA, E. I. ET AL., FARMATSIYA (SOFIA, vol. 22, 1972, pages 3
IGARASHI Y. ET AL.: "Glucosylquestiomycin, a novel antibiotic from Microbispora sp. TP-A0184: fermentation, isolation, structure determination, synthesis and biological activities", THE JOURNAL OF ANTIBIOTICS, vol. 51, no. 10, 1998, pages 915 - 920, XP003019322
NAKAJIMA Y. ET AL.: "Microbispora corallina sp. nov., a new species of the genus Microbispora isolated from Thai soil", INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, vol. 49, no. 4, 1999, pages 1761 - 1767, XP003019323
OKUJO N. ET AL.: "Bispolides, novel 20-membered ring macrodiolide antibiotics from microbispora", THE JOURNAL OF ANTIBIOTICS, vol. 60, no. 3, 25 March 2007 (2007-03-25), pages 216 - 219, XP003019324
ARCAMONE, F. M. ET AL., MICROBIOL., vol. 7, 1959, pages 207
ARAI, M, "ANTIBIOT." SER. A, 1960, pages 13
KHLEBAROVA, E. I. ET AL., FARMATSIYA (SOFIA, vol. 22, 1972, pages 3
Attorney, Agent or Firm:
HAMANO, Takao et al. (1-15 Nishi Shimbashi 1-chom, Minato-ku Tokyo 03, JP)
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