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Title:
NOVEL ANTISENSE OLIGONUCLEOTIDE DERIVATIVES AGAINST WILMS'S TUMOR GENE
Document Type and Number:
WIPO Patent Application WO/2002/006297
Kind Code:
A1
Abstract:
Antisenses against WT1 which comprise oligonucleotide derivatives containing 1 or more sugar-modified nucleotide analog units represented by the following general formula (2) wherein B represents a pyrimidine nucleic acid base, a purine nucleic acid base or an analog thereof. These antisenses, which are antisenses against Wilms's tumor (WT1) gene, are expected as antisense oligonucleotide derivatives capable of binding to WT1 at a high affinity in cells to thereby efficiently regulate or inhibit the expression of this gene and being highly resistant to nucleases.

Inventors:
IMANISHI TAKESHI (JP)
SUGIYAMA HARUO (JP)
OHSUGI YOSHIYUKI (JP)
Application Number:
PCT/JP2001/006049
Publication Date:
January 24, 2002
Filing Date:
July 12, 2001
Export Citation:
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Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
IMANISHI TAKESHI (JP)
SUGIYAMA HARUO (JP)
OHSUGI YOSHIYUKI (JP)
International Classes:
A61P35/00; C12N15/113; A61K38/00; A61K48/00; (IPC1-7): C07H21/00; A61K31/712; A61K48/00; A61P35/00; C12N15/11
Foreign References:
EP1004319A12000-05-31
EP0841068A11998-05-13
EP1013661A12000-06-28
Attorney, Agent or Firm:
Shamoto, Ichio (New Ohtemachi Bldg. 2-1 Ohtemachi 2-chome Chiyoda-ku, Tokyo, JP)
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