Title:
NOVEL APPROACH FOR SYNTHESIS OF CATECHINS
Document Type and Number:
WIPO Patent Application WO/2014/115174
Kind Code:
A3
Abstract:
A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+and/or-) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (-)-epicatechin; (vi) optionally simultaneously deprotecting and hydrogenation of the compound obtained from step (ii) to obtain racemic epicatechin.
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Inventors:
DUGAR SUNDEEP (IN)
MAHAJAN DINESH (IN)
RAI KUMAR SANTOSH (IN)
TRIPATI VINAYAK (IN)
PATIL ISHWAR RAKESH (IN)
MAHAJAN DINESH (IN)
RAI KUMAR SANTOSH (IN)
TRIPATI VINAYAK (IN)
PATIL ISHWAR RAKESH (IN)
Application Number:
PCT/IN2014/000061
Publication Date:
December 24, 2014
Filing Date:
January 27, 2014
Export Citation:
Assignee:
SPHAERA PHARMA PRIVATE LTD (IN)
International Classes:
C07D311/62; C07D311/64; C07H15/26
Domestic Patent References:
| WO2012101652A2 | 2012-08-02 | |||
| WO2007002877A1 | 2007-01-04 | |||
| WO2002020506A2 | 2002-03-14 |
Other References:
J.P .J.MARAIS ET AL.: "The Stereochemistry of Flavonoids", THE SCIENCE OF FLAVONOIDS, 2006, pages 1 - 46, XP008180284
Attorney, Agent or Firm:
ARVIND, Chitra (Amsoft Business Centre,,Unitech Trade Centre,,Sector 43, Gurgaon 2, IN)
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