Novel biaromatic compounds which activate receptors of PPAR type and their use in cosmetic or pharmaceutical compositions The invention relates, as novel and useful industrial products, to a novel class of biaromatic compounds which are activators of receptors of Peroxisome Proliferator-Activated Receptor type of subtype γ (PPARγ). It also relates to their process of preparation and to their use in pharmaceutical compositions intended for use in human or veterinary medicine or alternatively in cosmetic compositions. The activity of receptors of PPAR type has formed the subject of many studies. Mention may be made, by way of indication, of the publication entitled "Differential Expression of Peroxisome Proliferator-Activated Receptor Subtypes During the Differentiation of Human Keratinocytes", Michel Rivier et al., J. Invest. Dermatol., 111 , 1998, pp 1116-1121 , in which a large number of bibliographic references relating to receptors of PPAR type are listed. Mention may also be made, by way of indication, of the report entitled "The PPARs: From Orphan Receptors to Drug Discovery", Timothy M. Willson, Peter J. Brown, Daniel D. Sternbach and Brad R. Henke, J. Med. Chem., 2000, Vol. 43, pp 527-550. PPAR receptors activate transcription by binding to elements of DNA sequences, known as peroxisome proliferator response elements (PPRE), in the form of a heterodimer with retinoid X receptors (known as RXRs). Three subtypes of human PPARs have been identified and described: PPARα, PPARγ and PPARδ (or NUC1 ). PPARα is mainly expressed in the liver, while PPARδ is ubiquitous. PPARγ is the most widely studied of the three subtypes. All the references suggest a critical role for PPARγs in the regulation of the differentiation of adipocytes, where it is strongly expressed. It also plays a key role in systemic lipid homeostasis. It has been disclosed in particular in Patent Application WO 96/33724 that compounds which are selective for PPARγs, such as a prostaglandin J2 or D2, are potential active principles in the treatment of obesity and diabetes. Furthermore, the Applicant Company has already disclosed, in Patent Application WO 02/12210 and WO 03/055867, the use of biaromatic compounds which are activators of receptors of PPARγ type in the preparation of a pharmaceutical composition, the composition being intended for the treatment of skin disorders related to an anomaly in the differentiation of the epidermal cells. It does not thereby remain any less the case that it is still necessary to search for novel compounds exhibiting a good activity and advantageous pharmaceutical properties. The Applicant Company has now identified a novel family of derivatives exhibiting the advantage of being 10 to 100 times more active than the compounds identified in the preceding Patent Applications VVO 02/12210 and WO 03/055867 with regard to PPARγ receptors. Furthermore, in addition to their better activity, some of the compounds according to the present invention are obtained in the solid form. The synthesis thereof and the purification thereof are easier. Finally, the use of solid compounds makes it possible to avoid the disadvantages exhibited by oils in the context of the pharmaceutical development due to the residual solvents which may be present therein. Thus, the present invention relates to compounds corresponding to the following general formula (I):

in which: - R1 represents a hydroxyl radical, an -OR6 radical or a hydroxylamine radical; R6 being defined below, - R2 and R3, which are identical or different, represent a hydrogen atom, a halogen atom, an alkyl radical comprising 1 to 12 carbon atoms, a hydroxyl radical, an alkoxy radical, a polyether radical, an aralkyl radical, an aryl radical or an amino radical which can be substituted by one or two identical or different radicals chosen from an alkyl radical comprising 1 to 12 carbon atoms or an aralkyl radical; - R4 represents a hydrogen atom or a lower alkyl radical having from 1 to 4 carbon atoms; - R5 represents an alkyl radical having from 1 to 12 carbon atoms, an aryl radical, an aralkyl radical, a heteroaryl radical, a heterocyclic radical or a 9- fluorenylmethyl radical; - R6 represents an alkyl, aryl or aralkyl radical; - R7 and R8, which are identical or different, represent a hydrogen atom, a halogen atom, an alkyl radical comprising 1 to 12 carbon atoms, a hydroxyl radical, an alkoxy radical, a polyether radical, an aralkyl radical, an aryl radical or an amino radical which can be substituted by one or two identical or different radicals chosen from an alkyl radical comprising 1 to 12 carbon atoms or an aralkyl radical; - Y represents an oxygen or sulphur atom; - V-W represents a carbon-carbon single or double bond, that is to say a CH2-CH2 or CH = CH sequence, and the salts of the compounds of formula (I). In particular, when the compounds according to the invention are provided in the form of salts, they are salts of an alkali metal, in particular a sodium or potassium salt, or of an alkaline earth metal or salts of organic amines, more particularly of amino acids, such as arginine or lysine. When the compounds according to the invention have an amine functional group and are provided in the form of salts of this amine, they are salts of an inorganic acid, such as, for example, hydrochloric acid, sulphuric acid or hydrobromic acid, or salts of an organic acid, such as, for example, acetic acid, triflic acid, tartaric acid, oxalic acid, citric acid or nitric acid. According to the present invention, the term "hydroxyl radical" is understood to mean the -OH radical. According to the present invention, the term "alkyl radical comprising 1 to 12 carbon atoms" is understood to mean a linear, branched or cyclic and saturated or unsaturated carbon chain which can be interrupted by a heteroatom and which can be substituted by one or more radicals chosen from a halogen atom, a hydroxyl radical, an alkoxy radical or a heterocyclic radical and the alkyl radicals are preferably the methyl, ethyl, propyl, isopropyl, butyl, tert- butyl, isoamyl, amyl, hexyl, heptyl, octyl, decyl, cyclohexyl, methylcyclohexyl, methylcyclobutyl, methylcyclopentyl or methylcyclohexyl radicals. The term "lower alkyl radical comprising 1 to 4 carbon atoms" will preferably mean a methyl, ethyl, propyl, methylcyclopropyl, isopropyl, tert-butyl or n-butyl radical. The term "aryl radical" is understood to mean a phenyl, biphenyl, cinnamyl or naphthyl radical which can be substituted by a halogen atom, a CF3 radical, an alkyl radical, an alkoxy radical, a nitro functional group, a polyether radical, an aryl radical, a benzoyl radical, an alkyl ester group, a carboxylic acid, a hydroxyl radical optionally protected by an acetyl or benzoyl group or an amino radical optionally protected by an acetyl or benzoyl group or optionally substituted by at least one alkyl having from 1 to 12 carbon atoms, an aralkoxy radical, a phenoxy radical or an amide radical H2NCO. The term "aralkyl radical" is understood to mean an alkyl radical comprising 1 to 12 carbon atoms which is substituted by an aryl radical or by a heteroaryl radical. The term "halogen atom" is understood to mean a fluorine, chlorine, bromine or iodine atom. The term "alkoxy radical" is understood to mean an oxygen atom substituted by an alkyl radical comprising 1 to 12 carbon atoms and the alkoxy radicals are preferably the methoxy, ethoxy, isopropyloxy, n-propyloxy, tert- butoxy, n-butoxy, n-pentyloxy, n-hexyloxy, cyclopropylmethoxy, cyclobutylmethoxy, cyclopentylmethoxy or cyclohexylmethoxy radicals. The term "aralkoxy radical" is understood to mean an oxygen atom substituted by an aralkyl radical. The term "polyether radical" is understood to mean a radical having from 1 to 7 carbon atoms which is interrupted by at least one oxygen atom and preferably the radicals such as methoxyethoxy, ethoxyethoxy or methoxyethoxyethoxy radicals. The term "heteroaryl radical" is understood to mean an aryl radical which is interrupted by one or more heteroatoms, such as the pyridyl, furyl, thienyl, isoxazolyl, oxadiazolyl, oxazolyl, isothiazolyl, quinozalinyl, benzothiadiazolyl, benzimidazolyl, indolyl or benzofuranyl radical, and which is optionally substituted by at least one halogen, one alkyl radical having from 1 to 12 carbon atoms, one alkoxy radical, one aryl radical, one nitro functional group, one polyether radical, one heteroaryl radical, one benzoyl radical, one alkyl ester group, one carboxylic acid, one hydroxyl optionally protected by an acetyl or benzoyl group or one amino radical optionally protected by an acetyl or benzoyl group or optionally substituted by at least one alkyl having from 1 to 12 carbon atoms. The term "heterocyclic radical" is understood to mean preferably a morpholino, pyrrolidino, piperidino, piperazino, 2-oxopiperidin-1-yl and 2-oxopyrrolidin-1-yl radical which are optionally substituted by at least one alkyl radical having from 1 to 12 carbon atoms, one alkoxy radical, one aryl radical, one nitro functional group, one polyether radical, one heteroaryl radical, one benzoyl radical, one alkyl ester group, one carboxylic acid, one hydroxyl optionally protected by an acetyl or benzoyl group or one amino radical optionally protected by an acetyl or benzoyl group or optionally substituted by at least one alkyl having from 1 to 12 carbon atoms. The term "hydroxylamine radical" is understood to mean the - NHOH sequence. The term "alkyl ester radical" is understood to mean a carboxylate functional group substituted by an alkyl radical having 1 to 6 carbon atoms. Mention may in particular be made, among the compounds of formula (I) above coming within the scope of the present invention, of the following compounds (alone or as a mixture): 1 - 3-{3'-[((Methyl)(octanoyl)amino)methyl]biphenyl-4-yl}acrylic acid 2- 3-{3'-[((Methyl)(octanoyl)amino)methyl]biphenyl-4-yl}propano ic acid 3- 3-{3-Fluoro-3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4-y l}acrylic acid 4- 3-{3-Fluoro-3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4-y l}propanoic acid 5- 3-[3'-((Octanoylamino)rnethyl)biphenyl-4-yl]acrylic acid 6- 3-[3'-((Octanoylamino)methyl)biphenyl-4-yl]propanoic acid 7- 3-{3-Hydroxy-3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4- yl}propanoic acid 8- 3-{2-Butoxy-3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4-y l}propanoic acid 9- 3-{2-Butoxy-3'-[((hexanoyl)(methyl)amino)methyl]biphenyl-4-y l}propanoic acid 10- 3-{2-Butoxy-3'-[((methyl)(pentanoyl)amino)methyl]biphenyl-4- yl}propanoic acid 11- 3-{2-Butoxy-3'-[((heptanoyl)(methyl)amino)methyl]biphenyl-4- yl}propanoic acid 12- 3-(2-Butoxy-3'-{[(4-ethoxybenzoyl)(methyl)amino]-methyl}biph enyl-4- yl)propanoic acid 13- 3-(2-Butoxy-3'-{[(4-butoxybenzoyl)(methyl)amino]-methyl}biph enyl-4- yl)propanoic acid 14- 3-{3'-[((Benzoyl)(methyl)amino)methyl]-2-butoxy-biphenyl-4-y l}propanoic acid 15- 3-(2-Butoxy-3'-{[(4-methoxybenzoyl)(methyl)amino]-methyl}bip henyl-4- yl)propanoic acid 16- 3-(2-Butoxy-3'-{[(3-methoxybenzoyl)(methyl)amino]-methyl}bip henyl-4- yl)propanoic acid 17- (E)-3-{2-Fluoro-3'-[((methyl)(octanoyl)amino)methyl]biphenyl -4-yl}acrylic acid 18- 3-{2-Fluoro-3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4-y l}propanoic acid 19- 3-{2-(2-Methoxyethoxy)-3'-[((methyl)(octanoyl)amino)methyl]b iphenyl-4- yl}propanoic acid 20- 3-{2-(3-Methylbutoxy)-3'-[((methyl)(octanoyl)amino)methyl]bi phenyl-4- yljpropanoic acid 21- 3-{2-(3-Chloropropoxy)-3'-[((methyl)(octanoyl)amino)methyl]b iphenyl-4- yl}propanoic acid 22- 3-{2-Methoxy-31-[((methyl)(octanoyl)amino)methyl]biphenyl-4- yl}propanoic acid 23- 3-{2-Methyl-3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4-y l}propanoic acid 24- 3-(3'-{[Methyl(4-phenylbutyryl)amino]methyl}-biphenyl-4-yl)p ropanoic acid 25- (E)-3-{2'-Methyl-5'-[((methyl)(octanoyl)amino)nnethyl]biphen yl-4-yl}acrylic acid 26- 3-{2'-Methyl-5'-[((methyl)(octanoyl)amino)methyl]biphenyl-4- yl}propanoic acid 27- (E)-3-{2-Benzyloxy-3'-[((methyl)(octanoyl)amino)methyl]biphe nyl-4-yl}acrylic acid 28- 3-{2-Benzyloxy-3'-[((methyl)(octanoyl)amino)methyl]biphenyl- 4-yl}propanoic acid 29- 3-{3'-[((Methyl)(octanoyl)amino)methyl]-2-propoxy-biphenyl-4 -yl}propanoic acid 30- (E)-3-{3,5-Difluoro-3'-[((methyl)(octanoyl)amino)methyl]biph enyl-4-yl}acrylic acid 31- 3-{3,5-Difluoro-3'-[((methyl)(octanoyl)amino)methyl]biphenyl -4-yl}propanoic acid 32- 3-(3'-{[(4-Butoxybenzoyl)(methyl)amino]methyl}-biphenyl-4-yl )propanoic acid 33- 3-(3'-{[(4-Butoxybenzoyl)(ethyl)amino]methyl}-biphenyl-4-yl) propanoic acid 34- 3-{2-Cyclopropylmethoxy-3'-[((methyl)(octanoyl)amino)methyl] biphenyl-4- yljpropanoic acid 35- 3-{2-Ethoxy-3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4-y l}propanoic acid 36- 3-[3'-[((Methyl)(octanoyl)amino)methyl]-2-(3,3,3-trifluoropr opoxy)biphenyl-4- yl]propanoic acid 37- 3-[3'-[((Methyl)(octanoyl)amino)methyl]-2-(4,4,4-trifluorobu toxy)biphenyl-4- yl]propanoic acid 38- 3-{2-(3-Hydroxypropoxy)-3'-[((methyl)(octanoyl)amino)methyl] biphenyl-4- yl}propanoic acid 39- 3-{2-(4-Hydroxybutoxy)-3'-[((methyl)(octanoyl)amino)methyl]b iphenyl-4- yl}propanoic acid 40- 3-{2-(3-Fluorobenzyloxy)-3'-[((methyl)(octanoyl)amino)methyl ]biphenyl-4- yl}propanoic acid 41 - 3-{2-(4-Fluorobenzyloxy)-3'-[((methyl)(octanoyl)amino)methyl ]biphenyl-4- yljpropanoic acid 42- 3-{3'-[((Methyl)(octanoyl)amino)methyl]-2-(pentyloxy)bipheny l-4-yl}propanoic acid 43- 3-{3'-[((Hexanoyl)(methyl)amino)methyl]-2-(pentyloxy)bipheny l-4-yl}propanoic acid 44- 3-{2-(2-Ethoxyethoxy)-3'-[((hexanoyl)(methyl)amino)methyl]bi phenyl-4- yl}propanoic acid 45- 3-{2-(2-(Diethylamino)ethoxy)-3'-[((nnethyl)(octanoyl)amino) methyl]biphenyl-4- yl}propanoic acid 46- 3-[3'-[((Methyl)(octanoyl)amino)methyl]-2-(2-(morpholin-4-yl )ethoxy)biphenyl- 4-yl]propanoic acid 47- 3-{2-Amino-3'-[((hexanoyl)(methyl)amino)methyl]biphenyl-4-yl }propanoic acid 48- 3-{2-Butylamino-3'-[((hexanoyl)(methyl)amino)methyl]biphenyl -4-yl}propanoic acid 49- 3-{2-Benzylamino-3'-[((hexanoyl)(methyl)amino)methyl]bipheny l-4- yl}propanoic acid 50- 3-{2-Diethylamino-3'-[((hexanoyl)(methyl)amino)methyl]biphen yl-4- yl}propanoic acid 51- 3-{3'-[((Hexanoyl)(methyl)amino)methyl]-2-(propylamino)biphe nyl-4- yl}propanoic acid 52- 3-{2-(4-Fluorobenzylamino)-3'-[((hexanoyl)(methyl)amino)meth yl]biphenyl-4- yljpropanoic acid 53- 3-{2-Butylamino-3'-[((methyl)(octanoyl)amino)methyl]biphenyl -4-yl}propanoic acid 54- 3-{2-Benzylamino-3'-[((methyl)(octanoyl)amino)methyl]bipheny l-4-yl}propanoic acid 55- 3-{2-Diethylamino-3'-[((methyl)(octanoyl)amino)methyl]biphen yl-4-yl}propanoic acid 56- 3-{31-[((Methyl)(octanoyl)amino)methyl]-2-(propylamino)biphe nyl-4- yl}propanoic acid 57- 3-{2-(4-Fluorobenzylamino)-3'-[((methyl)(octanoyl)amino)meth yl]biphenyl-4- yljpropanoic acid 58- S^-Cyclohexylmethoxy-S'-KCinethylXoctanoyOaminoJmethyllbiphe nyl-^ yljpropanoic acid 59- 3-{2-Cyclopentylmethoxy-31-[((methyl)(octanoyl)amino)methyl] biphenyl-4- yljpropanoic acid 60- N-[2'-(2-Cyclobutylethoxy)-4'-(2-(hydroxycarbamoyl)ethyl)bip henyl-3- ylmethyl](methyl)octanamide 61- 3-[3'-[((Methyl)(octanoyl)amino)methyl]-2-(3- (trifluoromethyl)benzyloxy)biphenyl-4-yl]propanoic acid 62- 3-[3'-[((Hexanoyl)(methyl)amino)methyl]-2-(4- (trifluoromethyl)benzyloxy)biphenyl-4-yl]propanoic acid ΘS- S^-CS-CarbamoylbenzyloxyVS'-^methylXoctanoyOaminoJmethy^biph enyM- yl}propanoic acid 64- 3-[3'-[((Methyl)(octanoyl)amino)methyl]-2-(2-(piperazin-1 -yl)ethoxy)biphenyl-4- yl]propanoic acid 65- 3-[3'-[((Methyl)(octanoyl)amino)methyl]-2-(2-(pyrrolidin-1-y l)ethoxy)biphenyl-4- yl]propanoic acid 66- 3-[2-(3-Methoxybenzyloxy)-3'-({[3-(3- methoxyphenyl)propionyl](methyl)amino}methyl)biphenyl-4-yl]p ropanoic acid 67- 3-[2-(4-(tert-Butyl)benzyloxy)-3'-({methyl[3-(3- phenoxyphenyl)propionyl]amino}methyl)biphenyl-4-yl]propanoic acid 68- 3-(2-(3,5-Dimethoxybenzyloxy)-3'-{[methyl(3- phenoxybenzoyl)amino]methyl}biphenyl-4-yl)propanoic acid 69- 3-[3'-{[Methyl(4-phenoxybenzoyl)amino]methyl}-2-(3- (trifluoromethyl)benzyloxy)biphenyl-4-yl]propanoic acid 70- 3-[2-(3-lsopropoxybenzyloxy)-3'-({[3-(4- methoxyphenyl)propionyl](methyl)amino}methyl)biphenyl-4-yl]p ropanoic acid 71 - 3-[2'-(3-Methoxybenzyloxy)-5'-({[3-(3- methoxyphenyl)propionyl](methyl)amino}methyl)biphenyl-4-yl]p ropanoic acid 72- 3-{2'-Cyclohexylmethoxy-5'-[((hexanoyl)(methyl)amino)methyl] biphenyl-4- yl}propanoic acid 73- 3-{4'-Ethoxy-3'-[((hexanoyl)(methyl)amino)methyl]-2-propoxyb iphenyl-4- yl}propanoic acid 74- 3-{31-[((Hexanoyl)(methyl)amino)methyl]-3,5-dimethoxybipheny l-4-yl}propanoic acid 75- 3-[3,5-Diethoxy-3'-({[3-(3-methoxyphenyl)- propionyl](methyl)amino}methyl)biphenyl-4-yl]propanoic acid 76- 3-[31-({[3-(4-Methoxyphenyl)propionyl](methyl)amino}methyl)- 3- propoxybiphenyl-4-yl]propanoic acid 77- 3-{3-Cyclopropylmethoxy-3'-[((hexanoyl)(methyl)amino)methyl] biphenyl-4- yl}propanoic acid 78- 3-{3-Ethoxy-4l-fluoro-3'-[((hexanoyl)(methyl)amino)methyl]bi phenyl-4- yl}propanoic acid 79- 3-[3'-[((Hexanoyl)(methyl)amino)methyl]-3-(4,4)4-trifluorobu toxy)biphenyl-4- yljpropanoic acid 80- 3-{3-Benzyloxy-3'-[((hexanoyl)(methyl)amino)methyl]biphenyl- 4-yl}propanoic acid 81 - 3-[3'-({[3-(4-Methoxyphenyl)propionyl](methyl)amino}methyl)- 3-(3- (trifluoromethyl)benzyloxy)biphenyl-4-yl]propanoic acid 82- 3-[3'-({[3-(3-Methoxyphenyl)propionyl](methyl)amino}methyl)- 3,5- dipropylbiphenyl-4-yl]propanoic acid 83- 3-{3-(2,2-Dimethylpropyl)-3'-[((hexanoyl)(methyl)amino)methy l]biphenyl-4- yljpropanoic acid 84- 3-{31-[((Hexanoyl)(methyl)amino)methyl]-315-dimethylbiphenyl -4-yl}propanoic acid 85- 3-{3-[((Hexanoyl)(methyl)amino)methyl]-4"-methoxy-1 , 1 ';3', 1 "-terphenyl-41- yljpropanoic acid 86- 3-{3-[((Hexanoyl)(methyl)amino)methyl]-3"-methoxy-1 , 1 ';2\ 1 "-terphenyl-41- yljpropanoic acid 87- 3-[3-({[3-(3-Methoxyphenyl)propionyl](methyl)amino}methyl)-3 "-trifluoromethyl- 1 ,1';2',1"-terphenyl-4'-yl]propanoic acid 88- 3-{3'-[((Hexanoyl)(methyl)amino)methyl]-2-[2-(3- isopropoxyphenyl)ethyl]biphenyl-4-yl}propanoic acid 89- 3-{3'-[((Hexanoyl)(methyl)amino)methyl]-2-[(pyridin-3-ylmeth yl)amino]biphenyl- 4-yl}propanoic acid 90- 3-[3'-[((Hexanoyl)(methyl)amino)methyl]-3-(2-methoxyethylami no)biphenyl-4- yl]propanoic acid 91 - Methyl 3-{3,5-diethyl-3'-[((hexanoyl)(methyl)amino)methyl]biphenyl- 4- yl}propanoate 92- Methyl 3-[3'-{[methyl(3-phenoxybenzoyl)amino]-methyl}-2-(3- (trifluoromethyl)benzyloxy)biphenyl-4-yl]propanoate 93- Methyl 3-[3χ[(3-(biphenyl-4-yl)propionyl)(methyl)amino]methyl}-2-( 3- methoxybenzyloxy)biphenyl-4-yl]propanoate 94- Ethyl 3-[3'-({[3-(3-methoxyphenyl)propionyl](methyl)amino}methyl)- 2-(4,4,4- trifluorobutoxy)biphenyl-4-yl]propanoate 95- N-[4'-(2-(Hydroxycarbamoyl)ethyl)-4"-methoxy-1 , 1 ';3\ 1 "-terphenyl-3- ylmethyl](methyl)hexanamide. According to the present invention, the compounds of formula (I) which are more particularly preferred are those which exhibit at least one of the following characteristics: - R1 represents a hydroxyl radical; - R2 and R7 represent an alkoxy or aryloxy radical, an alkylamino radical or a polyether radical; - R3 and R8 represent a hydrogen atom; - R4 represents a lower alkyl radical comprising 1 to 4 carbon atoms; - R5 represents an alkyl radical comprising 3 to 8 carbon atoms or an aryl radical; - Y is an oxygen atom; - the V-W bond is a C-C single or double bond. In particular, preference will be given to the compounds of general formula (I) exhibiting all of the following characteristics: - R1 represents a hydroxyl radical; - R2 and R7 represent an alkoxy or aryloxy radical, an alkylamino radical or a polyether radical; - R3 and R8 represent a hydrogen atom; - R4 represents a lower alkyl radical comprising 1 to 4 carbon atoms; - R5 represents an alkyl radical comprising 3 to 8 carbon atoms or an aryl radical; - Y is an oxygen atom; - the V-W bond is a C-C single or double bond. Another subject-matter of the present invention is the processes for the preparation of the compounds of formula (I), in particular according to the reaction schemes given in Figure 1. Route 1-2-3-4-5-6-7-8-9 The amides 3 can be obtained by treating the corresponding amines 2 with acyl halides 1 possessing the desired chain. For example, octanoyl chloride can react with methylamine to provide the corresponding amide. The amides 3 can react with benzyl halides 4 in the presence of a base, such as NaH, for example, to give the compounds 5. The boronic ester 6 can be obtained by treating compound 5 with bis(pinacolato)diboron, for example in the presence of a palladium-based catalyst, such as [1 ,1 '-bis(diphenylphosphino)ferrocene]dichloropalladium(ll). Its corresponding boronic acid (R = H) can be obtained by using conventional conditions, such as, for example, the use of tert-butyl lithium, followed by addition to trimethyl borate. The aryl halides or triflates 11 can be obtained commercially or else can be synthesized by a Wittig reaction by treating the suitably substituted aldehydes 10 with methyl (triphenylphosphoranylidene)acetate, for example. A palladium coupling of Suzuki type between the boronate 6 and the appropriate reactant 11 (aryl bromide, iodide, chloride or triflate) makes it possible to obtain the compound exhibiting the aryl-aryl sequence 7. The acid functional group of the compound 8 can be obtained from 7 by saponification, if R6 is an alkyl chain, with a base, such as sodium hydroxide, or by hydrogenolysis, if R6 is a benzyl. The compound 9 can be obtained by hydrogenation, if 8 has V-W = CH = CH, under conventional hydrogenation conditions, such as, for example, hydrogen catalysed by palladium-on-charcoal. The compound 17 can be obtained from the acid 9 by treatment with oxalyl chloride, for example, followed by reaction with hydroxylamine. The compound 17 can be obtained from the ester 18 by treatment with hydroxylamine. The compound 7 can be subjected to a deprotection/protection sequence if R5 = O-(t-Bu). In this case, treatment with trifluoroacetic acid, for example, followed by reaction with an acyl chloride, can result in the compounds where R5 = alkyl. In the case where R2 = OBn, a hydrogenation reaction, in the presence of palladium-on-charcoal, for example, and under a hydrogen atmosphere, can be carried out on the compound 7 to provide the compounds 18 in which R2 = OH. The compounds 19 can be obtained by alkylation of the phenol under conventional conditions, such as, for example, in the presence of an alkyl halide and of potassium carbonate. The acid functional group of the compound 9 can be obtained from 18 or 19 by saponification, if R6 is an alkyl chain, with a base, such as sodium hydroxide. Route 10-11-12-16-14-7-8-9 The compounds 11 can be obtained from the corresponding aldehydes 10 by a Wittig reaction with methyl (triphenylphosphoranylidene)acetate. The boronic ester 12 can be obtained by treating the compound 11 with bis(pinacolato)diboron, for example in the presence of a palladium-based catalyst, such as [1 ,1 '-bis(diphenylphosphino)ferrocene]dichloropalladium(ll). A palladium coupling of Suzuki type between the boronate 12 and the appropriate reactant 13 (bromide, iodide, chloride) makes it possible to obtain the compound exhibiting the aryl-aryl sequence 14. The compound 14 can be subjected to a conventional acylation reaction with an acyl halide in order to provide the compound 7 in which R4 = H. A palladium coupling of Suzuki type between the boronate 12 and the appropriate reactant 5 (bromide, iodide, chloride) makes it possible to obtain the compounds exhibiting the aryl-aryl sequence 7, Route 6-10-15-7-8-9 A palladium coupling of Suzuki type between the boronate 6 (or the corresponding boronic acid) and the appropriate reactant 10 (aryl bromide, iodide, chloride or triflate) makes it possible to obtain the compound exhibiting the aryl- aryl sequence 15. The compound 7 can be obtained by a Wittig reaction by treating the corresponding compound 15 with methyl (triphenylphosphoranylidene)acetate, for example. Route 5-16-15-7-8-9 A palladium coupling of Suzuki type between the boronic acid 16 and the compound 5 (aryl bromide, iodide, chloride or triflate) makes it possible to obtain the compound exhibiting the aryl-aryl sequence 15. The compounds according to the invention exhibit modulatory properties with regard to receptors of PPAR type. This activity on PPARa1 δ and γ receptors is measured in a transactivation test and quantified by the dissociation constant Kdapp (apparent), as described in Example 17. The preferred compounds of the present invention exhibit a dissociation constant of less than or equal to 5000 nM and advantageously of less than or equal to 1000 nM. Preferably, the compounds are modulators of specific receptors of PPARγ type, that is to say that they exhibit a ratio of the Kdapp for the PPARα or PPARδ receptors to the Kdapp for the PPARγ receptors of greater than or equal to 10. Preferably, this PPARα/PPARγ or PPARδ/PPARγ ratio is greater than or equal to 50 and more advantageously greater than or equal to 100. Another subject-matter of the present invention is the compounds of formula (I) as described above as medicament. The compounds according to the invention are particularly highly suitable in the following fields of treatment: 1 ) for treating dermatological conditions linked to a disorder of keratinization involving differentiation and proliferation, in particular for treating acne vulgaris, comedonic or polymorphic acne, acne rosacea, nodulocystic acne, acne conglobata, senile acne or secondary acnes, such as solar, drug or occupational acne, 2) for treating other types of disorders of keratinization, in particular ichthyoses, ichthyosiform conditions, Darier's disease, palmoplanar keratoderma, leucoplakia and leucoplakiform conditions, or cutaneous or mucosal (oral) lichen, 3) for treating other dermatological conditions with an inflammatory immunoallergic component, with or without cell proliferation disorder, and, in particular, all forms of psoriasis, whether cutaneous, mucosal or ungual, and even psoriatic rheumatism, or alternatively cutaneous atopy, such as eczema, or respiratory atopy or alternatively gingival hypertrophy, 4) for treating all dermal or epidermal proliferations, whether they are benign or malignant and whether they are or are not of viral origin, such as common warts, flat warts and epidermodysplasia verruciformis, florid or oral papillomatoses, T lymphoma, and the proliferations which can be induced by ultraviolet radiation, in particular in the case of basal cell and prickle cell epithelioma, and also all precancerous skin lesions, such as keratoacanthomas, 5) for treating other dermatological disorders, such as immune dermatoses, such as lupus erythematosus, immune bullous diseases and collagen diseases, such as scleroderma, 6) in the treatment of dermatological or general conditions with an immunological component, 7) in the treatment of skin disorders due to exposure to UV radiation, and also for repairing or combating skin ageing, whether photoinduced or chronologic, or for reducing actinic keratoses and pigmentations, or any pathology associated with chronologic or actinic ageing, such as xerosis, 8) for combating disorders of the sebaceous function, such as hyperseborrhoea of acne or simple seborrhoea, 9) for preventing or treating disorders of cicatrization or for preventing or repairing stretch marks, 10) in the treatment of disorders of pigmentation, such as hyperpigmentation, melasma, hypopigmentation or vitiligo, 11 ) in the treatment of conditions of the metabolism of lipids, such as obesity, hyperlipidaemia or non-insulin-dependent diabetes, 12) in the treatment of inflammatory conditions, such as arthritis, 13) in the treatment or prevention of cancerous or precancerous conditions, 14) in the prevention or treatment of alopecia of various origins, in particular alopecia due to chemotherapy or to radiation, 15) in the treatment of disorders of the immune system, such as asthma, type I diabetes mellitus, multiple sclerosis or other selective dysfunctions of the immune system, 16) in the treatment of conditions of the cardiovascular system, such as arteriosclerosis or hypertension. Another subject-matter of the present invention is a pharmaceutical or cosmetic composition comprising, in a physiologically acceptable medium, at least one compound of formula (I) as defined above. Another subject-matter of the present invention is the use of the compounds of formula (I) in the manufacture of a composition intended for the treatment of the abovementioned conditions, in particular for regulating and/or restoring the metabolism of skin lipids. The composition according to the invention can be administered orally, enterally, parenterally, topically or ocularly. Preferably, the pharmaceutical composition is packaged in a form suitable for topical application. Orally, the composition, more particularly the pharmaceutical composition, can be provided in the form of tablets, including sugar-coated tablets, hard gelatin capsules, syrups, suspensions, solutions, powders, granules, emulsions or lipid or polymeric microspheres or nanospheres or vesicles which make possible controlled release. Parenterally, the composition can be provided in the form of solutions or suspensions for infusion or for injection. The compounds according to the invention are generally administered at a daily dose of approximately 0.001 mg/kg to 100 mg/kg of body weight, taken 1 to 3 times. The compounds are used systemically at a concentration generally of between 0.001% and 10% by weight, preferably between 0.01% and 1 % by weight, with respect to the weight of the composition. Topically, the pharmaceutical composition according to the invention is more particularly intended for the treatment of the skin and mucous membranes and can be provided in the form of salves, creams, milks, ointments, powders, impregnated pads, solutions, gels, sprays, lotions or suspensions. It can also be provided in the form of lipid or polymeric microspheres or nanospheres or vesicles or of polymeric patches and of hydrogels which make possible controlled release. This topical composition can be provided in the anhydrous form, in the aqueous form or in the form of an emulsion. The compounds are used topically at a concentration generally of between 0.001% and 10% by weight, preferably between 0.01 % and 1 % by weight, with respect to the total weight of the composition. The compounds of formula (I) according to the invention also have an application in the cosmetics field, in particular in body and hair hygiene and more particularly for regulating and/or restoring the metabolism of skin lipids. In comparison with the products known previously, these compounds of formula (I) have the advantage of additionally exhibiting other advantageous properties, in particular antiinflammatory or soothing properties, which makes them less irritating and therefore better tolerated compounds. Another subject-matter of the invention is thus the cosmetic use of a composition comprising, in a physiologically acceptable vehicle, at least one of the compounds of formula (I) for body or hair hygiene. The cosmetic composition according to the invention, comprising, in a cosmetically acceptable vehicle, at least one compound of formula (I) or one of its optical or geometrical isomers or one of its salts, can be provided in particular in the form of a cream, a milk, a lotion, a gel, lipid or polymeric microspheres or nanospheres or vesicles, a soap or a shampoo. The concentration of compound of formula (I) in the cosmetic composition is between 0.001% and 3% by weight, with respect to the total weight of the composition. The compositions as described above can, of course, additionally comprise inert or even pharmacodynamically active additives or combinations of these additives and in particular: wetting agents; depigmenting agents, such as hydroquinone, azelaic acid, caffeic acid or kojic acid; emollients; moisturizing agents, such as glycerol, polyethylene glycol (PEG) 400, thiamorpholinone and its derivatives, or urea; antiseborrhoeic or antiacne agents, such as S-carboxymethylcysteine, S-benzylcysteamine, their salts or their derivatives, or benzoyl peroxide; antifungal agents, such as ketoconazole or 4,5-polymethylene- 3-isothiazolidones; antibacterials; carotenoids and in particular β-carotene; antipsoriatic agents, such as anthralin and its derivatives; eicosa-5,8,11 ,14- tetraynoic and eicosa-5,8,11-triynoic acids, their esters and amides; and, finally, retinoids. The compounds of formula (I) can also be combined with vitamins D or their derivatives, with corticosteroids, with agents for combating free radicals, with α-hydroxy or α-keto acids or their derivatives, or with ion-channel blockers. These compositions can also comprise flavour enhancers, preservatives, such as esters of para-hydroxybenzoic acid, stabilizing agents, moisture-regulating agents, pH-regulating agents, agents for modifying osmotic pressure, emulsifying agents, UV-A and UV-B screening agents, or antioxidants, such as α-tocopherol, butylated hydroxyanisole or butylated hydroxytoluene. Of course, a person skilled in the art will take care to choose the optional compound or compounds to be added to these compositions so that the advantageous properties intrinsically attached to the present invention are not, or not substantially, detrimentally affected by the envisaged addition. Several examples of the preparation of active compounds of formula (I) according to the invention, along with results of biological activities of such compounds and various practical formulations based on these compounds, will now be given, by way of illustration and without any limiting nature. Example 1 : 3-(3'-r((Methyl)(octanoyl)amino)methvnbiphenyl-4-vnacrylic acid

a. N-Methyloctanamide 115 ml of triethylamine are added to a solution of 25 g (0.37 mol, 1 eq.) of methylamine hydrochloride in 125 ml of dichloromethane. 70 ml (0.41 mol, 1.1 eq.) of octanoyl chloride are slowly added at 00C. The reaction mixture is stirred at ambient temperature for 3 hours and then filtered, and 100 ml of water are added to the filtrate. The organic phase is separated by settling, dried over sodium sulphate and evaporated. 61 g of N-methyloctanamide are obtained with a quantitative yield. b. N-Methyl-N-(3-bromobenzyl)octanamide 5 g (31.8 mmol, 1 eq) of N-methyloctanamide are added at 00C to a suspension of 1.4 g (35 mmol, 1.1 eq.) of sodium hydride (60% in oil) in 60 ml of tetrahydrofuran. The reaction mixture is stirred at ambient temperature for 30 minutes and then a solution of 8.9 g (35 mmol, 1.1 eq.) of 3-bromobenzyl bromide in 15 ml of tetrahydrofuran is added. The mixture is stirred at ambient temperature for 16 hours. The reaction is halted by the addition of 100 ml of water and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is chromatographed on silica gel (heptane/ethyl acetate 75/25). 7.4 g of N-methyl-N- (3-bromobenzyl)octanamide are obtained. Yield = 71 %.

c. Methyl[3-(4.4.5.5-tetramethyl-1,3, 2-dioxaborolan-2-yl)benzyl]octanamide 1.0 g (3.98 mmol, 1.3 eq.) of bis(pinacolato)diboron is added to a mixture of 1.0 g (3.06 mmol, 1 eq.) of N-methyl-N-(3-bromobenzyl)octanamide and of 900 mg (9.18 mmol, 3 eq.) of potassium acetate in 10 ml of dimethylformamide in the presence of 111 mg (0.15 mmol, 5 mol%) of [1 ,1 '- bis(diphenylphosphino)ferrocene]dichloropalladium(ll) (PdCI2dppf). The mixture is stirred at 800C for 2 hours. The reaction is halted by the addition of 20 ml of water and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is chromatographed on silica gel (heptane/ethyl acetate 80/20). 1.0 g of methyl[3-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)benzyl]octanamide is obtained in the form of an oil. Yield = 88% d. Ethyl 3-(3'-f((methyl)(octanoyl)amino)methyllbiDhenyl-4-yl}acrylat e 30 mg (0.02 mmol, 5 mol%) of palladiumtetrakis(triphenylphosphine) are added to a solution of 200 mg (0.53 mmol, 1.0 eq.) of methyl[3-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2- yl)benzyl]octanamide and 204 mg (0.80 mmol, 1.5 eq.) of ethyl 4-bromocinnamate in 3 ml of a mixture of dimethylformamide and of a 2M potassium phosphate solution (6/1 ). The reaction mixture is stirred at 800C for 2 hours. The reaction is halted by the addition of 5 ml of water and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is chromatographed on silica gel (heptane/ethyl acetate 80/20). 145 mg of ethyl 3-(3'- [((methyl)(octanoyl)amino)methyl]biphenyl-4-yl}acrylate are obtained in the form of an oil. Yield = 63% e. S-β'-fffMethvflfoctanovDaminoϊmethyllbiDhenyl-A-vDacrylic acid 300 mg (7.5 mmol, 22 eq.) of sodium hydroxide are added to a solution of 145 mg (0.34 mmol, 1 eq.) of ethyl 3-(3'- [((methyl)(octanoyl)amino)methyl]biphenyl-4-yl}acrylate in 3 ml of tetrahydrofuran/methanol (9/1 ). The reaction mixture is stirred at ambient temperature for 2 hours. The reaction is halted by the addition of 20 ml of water and 3 ml of acetic acid and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is crystallized from pentane/dichloromethane. 110 mg of 3-{3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4-yl)acrylic acid are obtained in the form of a white powder. (M.p. = 124-125°C) Yield = 78% 1H NMR (CDCk 400 MHz): 0.88 (m, 3H), 1.30 (m, 8H), 1.71 (m, 2H), 2.44 (t, J = 7.6 Hz, 2H), 2.99 & 3.03 (2s (rotamers), 3H), 4.65 & 4.70 (2s (rotamers), 2H), 6.51 (2d (rotamers), J = 15.9 Hz, 1H), 7.22 (2d (rotamers), J = 6.6 Hz, 1H), 7.41-7.66 (m, 7H), 7.82 (2d (rotamers), J = 15.9 Hz, 1 H). Example 2: 3-(3M((MethylUoctanoyl)amino)methyllbiphenyl-4-yl>propano ic acid

a. Ethyl 3-{3'-f((methyl)(octanoyl)amino)methyl]biphenyl-4-yl)propano ate A solution of 169 mg (0.40 mmol, 1 eq.) of ethyl 3-(3'- [((methyl)(octanoyl)amino)methyl]biphenyl-4-yl}acrylate (prepared as is 1d) in 2 ml of methanol in the presence of 50 mg of 10% palladium-on-charcoal is stirred at ambient temperature for 2 hours under a hydrogen atmosphere. The palladium is filtered off and then the solvents are evaporated. The residue is chromatographed on silica gel (heptane/ethyl acetate 80/20). 136 mg of ethyl 3-{3'- [((methyl)(octanoyl)amino)methyl]biphenyl-4-yl}propanoate are obtained in the form of an oil. Yield = 80% b. 3-{3 '-[((Meth yl) (octano yl)amino)meth yljbiphen yl-4- yl) propanoic acid 300 mg (7.5 mmol, 23 eq.) of sodium hydroxide are added to a solution of 136 mg (0.32 mmol, 1 eq.) of ethyl 3-{3'- [((methyl)(octanoyl)amino)methyl]biphenyl-4-yl}propanoate in 3 ml of tetrahydrofuran/methanol (9/1 ). The reaction mixture is stirred at ambient temperature for 2 hours. The reaction is halted by the addition of 20 ml of water and 3 ml of acetic acid and then the extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is crystallized from pentane/dichloromethane. 85 mg of 3-{3'-[((methyl)(octanoyl)amino)methyl]- biphenyl-4-yl}propanoic acid are obtained in the form of a white powder. (M. p. = 910C) Yield = 65% 1H NMR (CDCk. 400 MHz): 0.88 (m, 3H), 1.30 (m, 8H), 1.70 (m, 2H), 2.41 (t, J = 7.5 Hz, 2H), 2.74 (m, 2H), 2.97 & 3.00 (2s (rotamers), 3H), 3.01 (m, 2H), 4.61 & 4.68 (2s (rotamers), 2H), 6.51 (2d e, J = 15.9 Hz, 1 H), 7.14 & 7.22 (2d (rotamers), J = 7.4 Hz, 1 H), 7.28-7.54 (m, 7H). Example 3: 3-{3-Fluoro-3'-r((methyl)(octanoyl)amino)methvHbiphenyl-4- vDacrylic acid

a. Methyl 3-(4-bromo-2-fluoroDhenyl)acrylate 2.17 g (6.5 mmol, 1.2 eq.) of methyl (triphenylphosphoranylidene)acetate are added to a solution of 1.1 g (5.4 mmol, 1.0 eq.) of 4-bromo-2-fluorobenzaldehyde in 10 ml of toluene. The reaction mixture is stirred at 800C for 1 hour. The reaction is halted by the addition of 20 ml of water and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is chromatographed on silica gel (heptane/ethyl acetate 80/20). 1.1 g of methyl 3-(4-bromo-2-fluorophenyl)acrylate are obtained in the form of a white solid. Yield = 78% b. Methyl 3-{3-fluoro-3'-f((methyl)(octanoyl)amino)methyl]biphenyl-4-y l}acrylate 500 mg (1.93 mmol, 1.0 eq.) of methyl 3-(4-bromo-2- fluorophenyl)acrylate and 721 mg (1.93 mmol, 1.0 eq.) of methyl[3-(4,4,5,5- tetramethyl-1 ,3,2-dioxaborolan-2-yl)benzyl]octanamide (prepared as in 1c) are dissolved in 12 ml of a mixture of dimethylformamide and of a 2M potassium phosphate solution (5/1 ). 111 mg (0.09 mmol, 5 mol%) of palladiumtetrakis(triphenylphosphine) are added and then the reaction mixture is stirred at 800C for 2 hours. The reaction is halted by the addition of 30 ml of water and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is chromatographed on silica gel (heptane/ethyl acetate 80/20). 615 mg of methyl 3-{3-fluoro-3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4- yl}acrylate are obtained. Yield = 75% c. 3-{3-Fluoro-3'-[((methyl)(octanoyl)amino)methyllbiphenyl-4-y l}acrylic acid 500 mg (12.5 mmol, 9 eq.) of sodium hydroxide are added to a solution of 615 mg (1.44 mmol, 1 eq.) of methyl 3-{3-fluoro-3'- [((methyl)(octanoyl)amino)methyl]biphenyl-4-yl}acrylate in 5 ml of tetrahydrofuran/methanol (9/1 ). The reaction mixture is stirred at ambient temperature for 2 hours. The reaction is halted by the addition of 20 ml of water and 3 ml of acetic acid and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is chromatographed on silica gel (dichloromethane/methanol 90/10). The oil obtained is crystallized from pentane. 510 mg of 3-{3-fluoro-3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4-y l}acrylic acid are obtained in the form of a white powder. (M. p. = 910C) Yield = 86% 1H NMR (CDCk. 400 MHz): 0.88 (m, 3H), 1.30 (m, 8H), 1.72 (m, 2H), 2.45 (m, 2H), 3.00 & 3.03 (2s (rotamers), 3H), 4.65 & 4.69 (2s (rotamers), 2H), 6.59 & 6.61 (2d rotamers, J = 16.1 Hz, 1 H), 7.28-7.63 (m, 7H), 7.91 & 7.93 (2d rotamers, J = 16.1 Hz, 1 H).

Example 4: 3-(3-Fluoro-3'-r((methyl)(octanovπamino)methyllbiphenyl-4- vDpropanoic acid

A solution of 200 mg (0.48 mmol, 1 eq.) of 3-{3-fluoro-3'- [((methylXoctanoyOaminoJmethylpphenyM-ylJacrylic acid (prepared as in 3c) in 3 ml of methanol in the presence of 50 mg of 10% palladium-on-charcoal is stirred at ambient temperature for 2 hours under a hydrogen atmosphere. The palladium is filtered off and then the solvents are evaporated. The residue is chromatographed on silica gel (dichloromethane/methanol 90/10). 154 mg of 3-{3- fluoro-3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4-yl)pro panoic acid are obtained. Yield = 78% 1H NMR (CDCI.. 400 MHz): 0.88 (m, 3H), 1.30 (m, 8H), 1.70 (m, 2H), 2.41 (t, J = 7.6 Hz, 2H), 2.74 (m, 2H), 2.97 & 3.00 (2s (rotamers), 3H), 3.05 (m, 2H), 4.62 & 4.67 (2s e, 2H), 7.18 & 7.49 (m, 7H). Example 5: S-raMfOctanoylaminolmethvObiphenyl-A-yllacrylic acid

a. Ethyl 3-(4-(4.4.5, 5-tetramethyl-1 '.3.2-dioxaborolan-2-yl)Dhenyllacrylate 1.1 g (4.3 mmol, 1.1 eq.) of bis(pinacolato)diboron are added to a mixture of 1.0 g (3.9 mmol, 1 eq.) of ethyl 4-bromocinnamate and 1.1 g (11.7 mmol, 3 eq.) of potassium acetate in the presence of 142 mg (0.19 mmol, 5 mol%) of [1 ,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(ll) (PdCI2dppf) in 10 ml of dimethylformamide. The mixture is stirred at 7O0C for 2 hours. The reaction is halted by the addition of 20 ml of water and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is chromatographed on silica gel (heptane/ethyl acetate 90/10). 1.15 g of ethyl 3-[4-(4,4,5,5-tetramethyl-1 ,3,2- dioxaborolan-2-yl)phenyl]acrylate are obtained in the form of an oil. Yield = 98% b. Ethyl 3-[3'-((octanoylamino)methyl)biDhenyl-4-yllacrylate 124 mg (0.10 mmol, 5 mol%) of palladiumtetrakis(triphenylphosphine) are added to a solution of 500 mg (2.14 mmol, 1.0 eq.) of 3-iodobenzylamine and 712 mg (2.36 mmol, 1.1 eq) of ethyl 3- [4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)phenyl]acrylate in 6 ml of a mixture of dimethylformamide and of a 2M potassium phosphate solution (5/1 ). The reaction mixture is stirred at 800C for 1 hour. The reaction is halted by the addition of 15 ml of water and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is dissolved in 25 ml of tetrahydrofuran. 2 ml of triethylamine are added, along with 0.5 ml (2.9 mmol, 1.4 eq.) of octanoyl chloride. The reaction mixture is stirred at ambient temperature for 1 hour. The reaction is halted by the addition of 20 ml of water and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is chromatographed on silica gel (heptane/ethyl acetate 70/30 down to 50/50). 430 mg of ethyl 3-[3'- ((octanoylamino)rnethyl)biphenyl-4-yl]acrylate are obtained. Yield = 49% c. 3-[3'-((Octanoylamino)methyl)biDhenyl-4-yl]acrylic acid 400 mg (10 mmol, 9 eq.) of sodium hydroxide are added to a solution of 430 mg (1.04 mmol, 1 eq.) of ethyl 3-[3'- ((octanoylamino)methyl)biphenyl-4-yl]acrylate in 8 ml of tetrahydrofuran/methanol (9/1). The reaction mixture is stirred at ambient temperature for 2 hours. The reaction is halted by the addition of 20 ml of water and 3 ml of acetic acid and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is chromatographed on silica gel (dichloromethane/methanol 80/20). The oil obtained is crystallized from heptane/dichloromethane. 230 mg of 3-[3'- ((octanoylamino)methyl)biphenyl-4-yl]acrylic acid are obtained in the form of a white powder. (M.p. = 176°C) Yield = 58% 1H NMR (dK-DMSO. 400 MHz): 0.83 (m, 3H), 1.24 (m, 8H), 1.53 (m, 2H), 2.15 (t, J = 7.6 Hz, 2H), 4.33 (d, J = 5.4 Hz, 2H), 6.58 (d, J = 15.9 Hz1 1 H), 7.26 (d, J = 7.0 Hz, 1H), 7.42 (t, J = 7.8 Hz, 1H), 7.58 (m, 3H), 7.69 (d, J = 8.0 Hz, 2H), 7.78 (d, J = 7.7 Hz, 2H), 8.35 (s, 1 H).

Example 6: 3-r3'-((Octanoylamino)methyl)biphenyl-4-vnpropanoic acid

A solution of 100 mg (0.26 mmol, 1 eq.) of 3-[3'- ((octanoylamino)methyl)biphenyl-4-yl]acrylic acid (prepared as in 5c) in 4 ml of methanol in the presence of 50 mg of 10% palladium-on-charcoal is stirred at ambient temperature for 6 hours under a hydrogen atmosphere. The palladium is filtered off and the solvents are evaporated. The residue is crystallized from dichloromethane/heptane and 65 mg of 3-[3'-((octanoylamino)methyl)biphenyl-4- yl]propanoic acid are obtained in the form of a white powder. (M.p. = 124-125°C) Yield = 65% 1H NMR (dR-DMSO. 400 MHz): 0.84 (m, 3H), 1.24 (m, 8H), 1.53 (m, 2H), 2.14 (t, J = 6.7 Hz, 2H), 2.57 (t, J = 7.0 Hz, 2H), 2.86 (t, J = 6.7 Hz, 2H), 4.33 (d, J = 5 Hz, 2H), 7.21 (d, J = 6.9 Hz, 1 H), 7.32 (d, J = 7.4 Hz1 2H), 7.39 (m, 1 H), 7.53 (m, 4H), 8.33 (s, 1 H), 12.1 1 (s, 1 H).

Example 7: 3-(3-Hvdroxy-3'-f((methylUoctanov0amino)methyllbiphenyl-4- yllpropanoic acid

a. Methyl 3-(2-benzyloxy-4-iodoDhenyl)acrylate 1.18 g (3.55 mmol, 1.2 eq.) of methyl (triphenylphosphoranylidene)acetate are added to a solution of 1.0 g (2.95 mmol, 1.0 eq.) of 2-benzyloxy-4-iodobenzaldehyde in 20 ml of toluene. The reaction mixture is stirred at 8O0C for 2 hours. The reaction is halted by the addition of 20 ml of water and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is filtered through silica gel (heptane/ethyl acetate 50/50). The oil obtained is crystallized from pentane and 830 mg of methyl 3-(2-benzyloxy-4-iodophenyl)acrylate are obtained in the form of a white solid. Yield = 71 % b. Meth yl 3-{3-benzyloxy-3 '-f((meth W) (octanoyl) amino)meth ylibiphen yl-4- vDacrylate 500 mg (1.26 mmol, 1.0 eq.) of methyl 3-(2-benzyloxy-4- iodophenyl)acrylate and 474 mg (1.26 mmol, 1.0 eq.) of methyl[3-(4,4,5,5- tetramethyl-1 ,3,2-dioxaborolan-2-yl)benzyl]octanamide (prepared as in 1c) are dissolved in 6 ml of a mixture of dimethylformamide and of a 2M potassium phosphate solution (5/1 ). 72 mg (0.06 mmol, 5 mol%) of palladiumtetrakis(triphenylphosphine) are added and then the reaction mixture is stirred at 800C for 2 hours. The reaction is halted by the addition of 30 ml of water and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is chromatographed on silica gel (heptane/ethyl acetate 80/20 down to 50/50). 530 mg of methyl 3-{3-benzyloxy-3'-[((methyl)(octanoyl)amino)- methyl]biphenyl-4-yl}acrylate are obtained. Yield = 82% c. 3-{3-Benzyloxy-3'-f((methyl)(octanoyl)amino)methyl]biphenyl- 4-yl}acrylic acid 400 mg (10 mmol, 10 eq.) of sodium hydroxide are added to a solution of 530 mg (1.03 mmol, 1 eq.) of methyl 3-{3-benzyloxy-3'- [((methyl)(octanoyl)amino)methyl]biphenyl-4-yl}acrylate in 2 ml of tetrahydrofuran/methanol (9/1 ). The reaction mixture is stirred at ambient temperature for 2 hours. The reaction is halted by the addition of 20 ml of water and 3 ml of acetic acid and then extraction is carried out with ethyl acetate. The organic phases are combined and dried over sodium sulphate. The solvents are evaporated and then the residue is chromatographed on silica gel (dichloromethane/methanol 90/10). 405 mg of 3-{3-benzyloxy-3'- [((methylXoctanoylJaminoJmethylJbiphenyW-ylJacrylic acid are obtained. Yield = 79% d. 3-{3-Hvdroxy-3'-{((methyl)(octanoyl)amino)methvπbiDhenyl-4- yl)proDanoic acid A solution of 405 mg (0.81 mmol, 1 eq.) of 3-{3-benzyloxy-3'- [((methylXoctanoyOaminoJmethylJbiphenyl^-ylJacrylic acid in 3 ml of methanol in the presence of 50 mg of 10% palladium-on-charcoal and of 20 μl of acetic acid is stirred at ambient temperature for 3 hours under a hydrogen atmosphere. The palladium is filtered off and then the solvents are evaporated. The residue is chromatographed on silica gel (dichloromethane/methanol 95/5). 135 mg of 3-{3- hydroxy-3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4-yl}pr opanoic acid are obtained. Yield = 40% 1H NMR (CDCk 400 MHz): 0.86 (m, 3H), 1.28 (m, 8H), 1.69 (m, 2H), 2.41 (t, J = 7.7 Hz, 2H), 2.81 (m, 2H), 2.95 & 2.99 (2s (rotamers), 3H), 2.99 (m, 2H), 4.59 & 4.64 (2s e, 2H), 7.02-7.46 (m, 7H).

Example 8: 3-(2-Butoxy-3'-f((methyl)(octanoyl)amino)methyllbiphenyl-4- yllpropanoic acid

a. 3-Hvdroxy-4-iodobenzoic acid 21.0 g (0.52 mol, 1.05 eq.) of sodium hydroxide and then 78.7 g (0.52 mol, 1.05 eq.) of sodium iodide are added to a solution of 69.1 g (0.5 mol, 1 eq.) of 3-hydroxybenzoic acid in 700 ml of methanol. The reaction mixture is cooled to 00C and then aqueous sodium hypochlorite solution (0.52 mol, 1.05 eq.) is added dropwise. The reaction medium is stirred at 0-50C for 2 hours and then at ambient temperature overnight. The methanol is evaporated and then the reaction medium is acidified with a concentrated hydrochloric acid solution. The precipitated product is filtered off, washed with water and dried. 121 g of 3- hydroxy-4-iodobenzoic acid are obtained in the form of an off-white solid. Yield = 92% b. Methyl 3-hvdroxy-4-iodobenzoate 59 ml (1.10 mol, 2.4 eq.) of sulphuric acid are added to a solution of 121 g (0.458 mol, 1 eq.) of 3-hydroxy-4-iodobenzoic acid in 700 ml of methanol. The reaction mixture is heated at reflux for 6 days. The methanol is evaporated and then the reaction medium is poured into water and extracted with ethyl acetate. The organic phases are combined, washed with water and dried over sodium sulphate. The solvent is concentrated and the solid obtained is filtered off and dried. 88.56 g of methyl 3-hydroxy-4-iodobenzoate are obtained in the form of white crystals. Yield = 70% c. Methyl 3-butoxy-4-iodobenzoate In a manner analogous to Example 26b, by reaction of 21.5 ml (0.189 mol, 1.5 eq.) of 1-iodobutane and of 35.03 g (0.126 mol, 1 eq.) of methyl 3- hydroxy-4-iodobenzoate in 350 ml of methyl ethyl ketone in the presence of 52.24 g (0.378 mol, 3 eq.) of potassium carbonate at 85°C for 2 1/2 hours, 41.78 g of methyl 3-butoxy-4-iodobenzoate are obtained in the form of white crystals after washing with heptane. Yield = 99% d. (3-Butoxy-4-iodophen yl) methanol 8.17 g (0.375 mol, 3 eq.) of lithium borohydride are added to a solution of 41.78 g (0.125 mol, 1 eq.) of methyl 3-butoxy-4-iodobenzoate in 210 ml of tetrahydrofuran. The reaction medium is heated at 600C for 2 hours and is then gently hydrolysed in an ice-cold and saturated ammonium chloride solution. The reaction medium is neutralized with concentrated hydrochloric acid and then extracted with ethyl acetate. The organic phases are washed with water and dried over magnesium sulphate. The solvent is evaporated and 38.31 g of (3-butoxy-4- iodophenyl)methanol are obtained in the form of a whitish oil. Yield = 100% e. 3-Butoxy-4-iodobenzaldehvde 89.5 g (0.875 mol, 7 eq.) of manganese dioxide are added to a solution of 38.30 g (0.125 mol, 1 eq.) of (3-butoxy-4-iodophenyl)methanol in 250 ml of dichloromethane. The reaction medium is stirred at ambient temperature for 18 hours and then filtered through silica gel. The solvent is evaporated and 29.61 g of 3-butoxy-4-iodobenzaldehyde are obtained in the form of an orange oil. Yield = 78% f. Methyl (E)-3-(3-butoxy-4-iodophenyl)acrylate 65.08 g (0.195 mol, 2 eq.) of methyl (triphenylphosphoranylidene)acetate are added to a solution of 29.60 g (0.097 mol, 1 eq.) of 3-butoxy-4-iodobenzaldehyde in 360 ml of toluene. The reaction mixture is heated at reflux for 2 hours. The solvent is evaporated and the oil obtained is chromatographed on silica gel (heptane/dichloromethane 50/50). 30.47 g of methyl (E)-3-(3-butoxy-4-iodophenyl)acrylate are obtained in the form of pale yellow crystals. Yield = 87% α. Meth yl (E) -3-{2-butoxy-3 '-[((meth yl) (octano yl)amino)meth yllbiohen yl-4- vDacrylate 4.5 mg (1 mol%) of palladium acetate and 14 mg (2 mol%) of biphenyldicyclohexylphosphine are added to a solution of 720 mg (2.0 mmol, 1 eq.) of methyl (E)-3-(3-butoxy-4-iodophenyl)acrylate (prepared in stage f) and of 971 mg (2.6 mmol, 1.3 eq.) of methyl [3-(4,4,5,5-tetramethyl-1 ,3,2-dioxoborolan-2- yl)benzyl]octanamide (prepared in Example 1c) in 12 ml of a mixture of dimethylformamide and of a 2M potassium phosphate solution (5/1 ). The mixture is heated at 900C for 2 hours. The reaction medium is hydrolysed in an ammonium chloride solution and then extracted with ethyl acetate. The organic phases are combined, washed with water and dried over magnesium sulphate. The solvent is evaporated and then the residual oil is chromatographed on silica gel (heptane/ethyl acetate 75/25). 946 mg of methyl (E)-3-{2-butoxy-3'- [((methyl)(octanoyl)amino)methyl]biphenyl-4-yl}acrylate are obtained in the form of an orange-pink oil. Yield = 98% jr. Methyl 3-{2-butoxy-3 '-[((meth yl) (octanoyl) amino) meth yljbiphen yl-4- yDoropanoate A solution of 916 mg (1.91 mmol, 1 eq.) of methyl (E)-3-{2-butoxy- 3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4-yl}acrylate in 10 ml of methanol in the presence of 92 mg (10% by weight) of 10% palladium-on-charcoal is stirred at ambient temperature for 3 1/2 hours under a hydrogen atmosphere. The palladium is filtered off through celite and then the solvent is evaporated. 902 mg of methyl 3-{2-butoxy-3'-[((methyl)(octanoyl)amino)methyl]biphenyl-4- yl}propanoate are obtained in the form of a yellowish oil. Yield = 98% /. 3-{2-Butoxy-3'-[((rr)ethyl)(octanoyl)amino)methyllbiDhenyl-4 -yl}Dropanoic acid 740 mg (18.5 mmol, 10 eq.) of sodium hydroxide are added to a solution of 891 mg (1.85 mmol, 1 eq.) of methyl 3-{2-butoxy-3'- [((methyl)(octanoyl)amino)methyl]biphenyl-4-yl}propanoate in 20 ml of methanol. The reaction mixture is stirred at ambient temperature for 24 hours. The reaction medium is evaporated to dryness, the residue is taken up in water, acidification is carried out with a 2N hydrochloric acid solution and extraction is carried out with ethyl acetate. The organic phases are combined, washed with water and dried over magnesium sulphate. The solvent is evaporated and the oil obtained is chromatographed on silica gel (FlashSmart column 35 g) eluted with dichloromethane/methanol (98/2). 725 mg of 3-{2-butoxy-3'- [((methyl)(octanoyl)amino)methyl]biphenyl-4-yl}propanoic acid are obtained in the form of a whitish oil. Yield = 84% 1H NMR (CDCU. 400 MHz): 0.86 (t, 3H), 0.91 (t, 3H), 1.24-1.40 (m, 10H), 1.67- 1.70 (m, 4H), 2.39 (m, 2H), 2.72 (t, 2H), 2.93 (d, 3H), 2.96-3.0 (m, 2H), 3.92-3.96 (m, 2H), 4.56-4.63 (d, 2H), 6.82-6.87 (m, 2H), 7.10-7.20 (d, 1 H), 7.23 (t, 1 H), 7.33- 7.46 (m, 3H).

Example 9: 3-(2-Butoxy-3'-r((hexanoyl)(methyl)amino)methvHbiphenyl-4- vDpropanoic acid

a. tert-Butyl (3-bromobenzyl)carbamate A solution of 25.0 g (0.11 mol, 1 eq.) of 3-bromobenzylamine hydrochloride and of 24.52 g (0.11 mol, 1 eq.) of di(tert-butyl) dicarbonate in 250 ml of dichloromethane in the presence of 15.6 ml (0.11 mol, 1 eq.) of triethylamine is stirred at ambient temperature for 16 hours. The reaction medium is washed with water and separated by settling, and the organic phase is dried over sodium sulphate. The solvent is evaporated and 32.41 g of tert-butyl (3-bromobenzyl)carbamate are obtained in the form of crystals. Yield = 100% b. tert-Butyl (3-bromobenzyl)(methyl)carbamate 5.4 g (0.134 mol, 1.2 eq.) of 60% sodium hydride are added to a solution of 32.0 g (0.111 mol, 1 eq.) of tert-butyl (3-bromobenzyl)carbamate in 450 ml of dimethylformamide. The reaction medium is stirred at ambient temperature for 30 minutes and then 20.9 ml (0.335 mol, 3 eq.) of iodomethane are added. The reaction medium is stirred at ambient temperature for 20 hours, then hydrolysed in water and extracted with ethyl acetate. The organic phases are combined, washed with a saturated sodium chloride solution and dried over sodium sulphate. The solvent is evaporated and 36.23 g of tert-butyl (3- bromobenzyl)(methyl)carbamate are obtained in the form of an orange oil. Yield = 100% £ tert-Butyl meth yl[3-(4.4.5.5-tetramethyl- 1.3.2-dioxaborolan-2- vDbenzyllcarbamate In a manner analogous to Example 1c, by reaction of 33.0 g (0.11 mol, 1 eq.) of tert-butyl (3-bromobenzyl)(methyl)carbamate, of 29.3 g (0.115 mol, 1.05 eq.) of bis(pinacolato)diboron and of 32.3 g (0.33 mol, 3 eq.) of potassium acetate in 500 ml of dimethylformamide in the presence of 3.6 g (4 mol%) of [1 ,1'- bis(diphenylphosphino)ferrocene]dichloropalladium(ll) (PdCI2dppf), 31.56 g of tert- butyl methyl[3-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)benzyl]carbamate are obtained, after chromatography on silica gel (heptane/ethyl acetate 90/10), in the form of a green oil. Yield = 83% d. Methyl (E) -3-{2-butoxy-3 '-[((tert-butoxycarbon yl) (meth yl) amino) meth yljbiphenyl- 4-yl)acrylate In a manner analogous to Example 8g, by reaction of 3.6 g (10.0 mmol, 1 eq.) of methyl (E)-3-(3-butoxy-4-iodophenyl)acrylate (prepared in Example 8f) and of 4.51 g (13 mmol, 1.3 eq.) of tert-butyl methyl[3-(4,4,5,5- tetramethyl-1 ,3,2-dioxaborolan-2-yl)benzyl]carbamate in 60 ml of a mixture of dimethylformamide and of a 2M potassium phosphate solution (5/1) in the presence of 22 mg (1 mol%) of palladium acetate and of 14 mg (2 mol%) of biphenyldicyclohexylphosphine, 3.87 g of methyl (E)-3-{2-butoxy-3'-[((tert- butoxycarbonyl)(methyl)amino)methyl]biphenyl-4-yl}acrylate are obtained in the form of a yellowish oil. Yield = 85% e. Methyl 3-{2-butoχy-3'-ff(tert-butoxycarbonyl)(methyl)amino)methyll biphenyl-4- vDpropanoate In a manner analogous to Example 8h, by reaction of 3.86 g (8.51 mmol, 1 eq.) of methyl (E)-3-{2-butoxy-3'-[((tert-butoxycarbonyl)(methyl)amino)- methyl]biphenyl-4-yl}acrylate in 10 ml of methanol in the presence of 386 mg (10% by weight) of 10% palladium-on-charcoal, 3.32 g of methyl 3-{2-butoxy-3'- [((tert-butoxycarbonyl)(methyl)amino)methyl]biphenyl-4-yl}pr opanoate are obtained in the form of a colourless oil. Yield = 86% f. Methyl 3-(2-butoxy-3'-(methylaminomethyl)biphenyl-4-yl)Dropanoate A solution of 3.31 g (7.27 mmol, 1 eq.) of methyl 3-{2-butoxy-3'- [((tert-butoxycarbonyl)(methyl)amino)methyl]biphenyl-4-yl}pr opanoate in 40 ml of dichloromethane in the presence of 5.4 ml (72.7 mmol, 10 eq.) of trifluoroacetic acid is stirred at ambient temperature for 2 hours. The solvents are evaporated and the oil obtained is chromatographed on silica gel (FlashSmart column 120 g) eluted with dichloromethane/methanol (97/3). 3.32 g of methyl 3-(2-butoxy-3'- (methylaminomethyl)biphenyl-4-yl)propanoate are obtained in the form of a whitish oil. Yield = 100% g, Methyl 3-{2-butoxy-3'-[((hexanoyl)(methyl)amino)methyl]biphenyl-4- vDpropanoate A solution of 480 mg (1.35 mmol, 1 eq.) of methyl 3-(2-butoxy-3'- (methylarninomethyl)biphenyl-4-yl)propanoate and of 377 μl (2.70 mmol, 2 eq.) of hexanoyl chloride in 15 ml of dichloromethane in the presence of 560 μl (4.05 mmol, 3 eq.) of triethylamine and of 16 mg (10 mol%) of 4-dimethylaminopyridine is stirred at ambient temperature for 16 hours. The reaction medium is hydrolysed with a 2N hydrochloric acid solution and separated by settling. The organic phase is washed with water and dried over magnesium sulphate. The solvent is evaporated and the oil obtained is chromatographed on silica gel (FlashSmart column 35 g) eluted with heptane/ethyl acetate (70/30). 400 mg of methyl 3-{2- butoxy-3'-[((hexanoyl)(methyl)amino)methyl]biphenyl-4-yl}pro panoate are obtained in the form of an oil. Yield = 65% h. 3-{2-Butoxy-3'-ϊ((hexanoyl)(methyl)amino)methyllbiphenyl-4- yl}propanoic acid A solution of 390 mg (0.86 mmol, 1 eq.) of methyl 3-{2-butoxy-3'- [((hexanoyl)(methyl)amino)methyl]biphenyl-4-yl}propanoate and of 4.3 ml (4.3 mmol, 5 eq.) of a 1 N lithium hydroxide solution in 10 ml of tetrahydrofuran is stirred at ambient temperature for 20 hours. The reaction medium is concentrated, acidified with a 2N hydrochloric acid solution and then extracted with ethyl acetate. The organic phases are combined, washed with water and dried over magnesium sulphate. The solvent is evaporated and the oil obtained is chromatographed on silica gel (FlashSmart column 20 g) eluted with dichloromethane/methanol (98/2). 378 mg of 3-{2-butoxy-3'- [((hexanoyl)(methyl)amino)methyl]biphenyl-4-yl}propanoic acid are obtained in the form of a yellowish oil. Yield = 100% 1H NMR (CDCk. 400 MHz): 0.86-0.91 (m, 6H)1 1.28-1.41 (m, 6H), 1.65-1.70 (m, 4H)1 2.38 (m, 2H)1 2.72 (t, 2H), 2.93 (d, 3H)1 2.96-3.0 (m, 2H)1 3.92-3.96 (m, 2H)1 4.56-4.63 (d, 2H)1 6.82-6.87 (m, 2H)1 7.05-7.15 (d, 1 H), 7.22 (t, 1 H), 7.33-7.46 (m, 3H).

Example 10: 3-l2-Butoxy-3'-r((methvO(pentanoyl)amino)methvπbiphenyl-4- yllpropanoic acid

a Methyl 3-{2-butoxy-3'-[((methyl)(Dentanoyl)amino)methyl]biDhenyl-4- vDoropanoate In a manner analogous to Example 9g, by reaction of 480 mg (1.35 mmol, 1 eq.) of methyl 3-(2-butoxy-3'-(rnethylaminomethyl)biphenyl-4- yl)propanoate (prepared in Example 9f) and of 327 μl (2.70 mmol, 2 eq.) of pentanoyl chloride in 15 ml of dichloromethane in the presence of 560 μl (4.05 mmol, 3 eq.) of triethylamine and of 16 mg (10 mol%) of 4-dimethylaminopyridine, 390 mg of methyl 3-{2-butoxy-3'-[((methyl)(pentanoyl)amino)methyl]biphenyl-4- yl}propanoate are obtained in the form of an oil. Yield = 66% b. 3-{2-Butoxy-3'-f((methyl)(pentanoyl)amino)methyllbiDhenyl-4- yl)propanoic acid In a manner analogous to Example 9h, by reaction of 380 mg (0.864 mmol, 1 eq.) of methyl 3-{2-butoxy-3'-[((methyl)(pentanoyl)amino)- methyl]biphenyl-4-yl}propanoate and of 4.3 ml (4.3 mmol, 5 eq.) of a 1 N lithium hydroxide solution in 10 ml of tetrahydrofuran, 361 mg of 3-{2-butoxy-3'- [((methyl)(pentanoyl)amino)methyl]biphenyl-4-yl}propanoic acid are obtained in the form of a yellowish oil. Yield = 98% 1H NMR (CDCk 400 MHz): 0.87-0.96 (m, 6H), 1.35-1.42 (m, 4H), 1.65-1.70 (m, 4H), 2.38 (m, 2H), 2.73 (t, 2H), 2.94 (d, 3H), 2.98-3.1 (m, 2H), 3.93-3.96 (m, 2H), 4.56-4.63 (d, 2H), 6.82-6.87 (m, 2H), 7.05-7.15 (d, 1 H), 7.22 (t, 1 H), 7.33-7.44 (m, 3H).

Example 11 : 3-(2-Butoxy-3'-r((heptanoylUmethyl)amino)methyllbiphenyl-4- yllpropanoic acid

a Methyl 3-{2-butoxy-3'-[((heDtanoyl)(methyl)amino)methyllbiphenyl-4- ylipropanoate In a manner analogous to Example 9g, by reaction of 480 mg (1.35 mmol, 1 eq.) of methyl 3-(2-butoxy-3'-(methylaminomethyl)biphenyl-4- yl)propanoate (prepared in Example 9f) and of 418 μl (2.70 mmol, 2 eq.) of heptanoyl chloride in 15 ml of dichloromethane in the presence of 560 μl (4.05 mmol, 3 eq.) of triethylamine and of 16 mg (10 mol%) of 4-dimethylaminopyridine, 410 mg of methyl 3-{2-butoxy-3'-[((heptanoyl)(methyl)amino)methyl]biphenyl-4- yljpropanoate are obtained in the form of an oil. Yield = 65% b. 3-{2-Butoxy-3'-f((heptanoyl)(methyl)amino)methyllbiDhenyl-4- yl)propanoic acid In a manner analogous to Example 9h, by reaction of 400 mg (0.855 mol, 1 eq.) of methyl 3-{2-butoxy-3'-[((heptanoyl)(methyl)amino)- methyl]biphenyl-4-yl}propanoate and of 4.3 ml (4.3 mmol, 5 eq.) of a 1 N lithium hydroxide solution in 10 ml of tetrahydrofuran, 378 mg of 3-{2-butoxy-3'- [((heptanoyl)(methyl)amino)methyl]biphenyl-4-yl}propanoic acid are obtained in the form of a yellowish oil. Yield = 97.5% 1H NMR (CDCh. 400 MHz): 0.85-0.93 (m, 6H), 1.26-1.41 (m, 8H), 1.67-1.70 (m, 4H), 2.39 (m, 2H), 2.73 (m, 2H)1 2.94 (d, 3H), 2.98-3.01 (m, 2H), 3.93-3.96 (m, 2H), 4.56-4.63 (d, 2H), 6.82-6.87 (m, 2H), 7.05-7.15 (d, 1 H)1 7.22 (t, 1 H), 7.33- 7.44 (m, 3H). Example 12: 3-(2-Butoxy-3'-M4-ethoxybenzoylWmethvn- aminolmethyl}biphenyl-4-yl)propanoic acid

a. Methyl 3-(2-butoxy-3'-{[(4-ethoxybenzoyl)(methyl)aminolmethyl)biphe nyl-4- vDpropanoate In a manner analogous to Example 9g, by reaction of 400 mg (1.12 mmol, 1 eq.) of methyl 3-(2-butoxy-3'-(methylaminomethyl)biphenyl-4- yl)propanoate (prepared in Example 9f) and of 220 μl (1.40 mmol, 1.2 eq.) of A- ethoxybenzoyl chloride in 10 ml of dichloromethane in the presence of 500 μl (3.58 mmol, 3.2 eq.) of triethylamine at ambient temperature for 12 hours, methyl 3-(2-butoxy-3'-{[(4-ethoxybenzoyl)(methyl)amino]methyl}biphe nyl-4-yl)propanoate is obtained in the form of an oil which is used as is in the following reaction. b. 3-(2-Butoxy-3'-{[(4-ethoxybenzoyl)(methyl)aminolmethyl}biphe nyl-4- vDpropanoic acid In a manner analogous to Example 1e, by reaction of 400 mg (10 mmol) of sodium hydroxide and of the methyl 3-(2-butoxy-3'-{[(4- ethoxybenzoyl)(methyl)amino]methyl}biphenyl-4-yl)propanoate prepared in the preceding stage in 10 ml of tetrahydrofuran/methanol (8/2), 360 mg of 3-(2- butoxy-3'-{[(4-ethoxybenzoyl)(methyl)amino]methyl}biphenyl-4 -yl)propanoic acid are obtained in the form of a gum after chromatography on silica gel (heptane/ethyl acetate 70/30). Yield = 66% over the 2 stages. 1H NMR (CDCK. 400 MHz): 0.88 (t, 3H), 1.35-1.43 (m & t, 5H), 1.64-1.69 (m, 2H), 2.68 (t, 2H), 2.98 (t & m, 5H), 3.94 (t, 2H), 4.01-4.06 (m, 2H), 4.60 & 4.75 (2m (rotamers), 2H), 6.81 (s, 1 H), 6.82-6.87 (m, 3H), 7.10-7.24 (m, 2H), 7.38 (t, 1 H), 7.43-7.46 (m, 4H). Example 13; 3-(2-Butoxy-3'-M4-butoxybenzoylUmethvn- amino1methyl>biphenyl-4-yl)propanoic acid

a. Methyl 3-(2-butoχy-3'-{f(4-butoxybenzoyl)(methyl)amino1methyl)bioh enyl-4- vDoropanoate In a manner analogous to Example 9g, by reaction of 400 mg (1.12 mmol, 1 eq.) of methyl 3-(2-butoxy-3'-(methylaminomethyl)biphenyl-4- yl)propanoate (prepared in Example 9f) and of 250 μl (1.40 mmol, 1.2 eq.) of 4- butoxybenzoyl chloride in 10 ml of dichloromethane in the presence of 500 μl (3.58 mmol, 3.2 eq.) of triethylamine at ambient temperature for 12 hours, methyl 3-(2-butoxy-3'-{[(4-butoxybenzoyl)(methyl)amino]methyl}biphe nyl-4-yl)propanoate is obtained in the form of an oil which is used as is in the following reaction. b. 3-(2-Butoxy-3 '-{[(4-butoxybenzoyl) (meth vDaminolmeth yl}biphenyl-4- vDpropanoic acid In a manner analogous to Example 1e, by reaction of 400 mg (10 mmol) of sodium hydroxide and of the methyl 3-(2-butoxy-3'-{[(4- butoxybenzoyl)(methyl)amino]methyl}biphenyl-4-yl)propanoate prepared in the preceding stage in 10 ml of tetrahydrofuran/methanol (8/2), 345 mg of 3-(2- butoxy-3'-{[(4-butoxybenzoyl)(methyl)amino]methyl}biphenyl-4 -yl)propanoic acid are obtained in the form of a gum after chromatography on silica gel (heptane/ethyl acetate 70/30). Yield = 60% over the 2 stages. 1H NMR (CDCU. 400 MHz): 0.88 (t, 3H), 0.97 (t, 3H), 1.35-1.40 (m, 2H), 1.45-1.51 (m, 2H), 1.64-1.69 (m, 2H), 1.74-1.78 (m, 2H)1 2.68 (t, 2H), 2.98 (t & m, 5H), 3.93- 3.98 (m, 4H), 4.60 & 4.75 (2m e, 2H), 6.82 (s, 1H), 6.84-6.88 (m, 3H), 7.10-7.25 (m, 2H), 7.38 (t, 1 H), 7.42-7.46 (m, 4H). Example 14: 3-{3'W((BenzoylUmethvπamino)methyll-2-butoxybiphenyl-4- yllpropanoic acid

a Methyl 3-{3'-f((benzoyl)(methyl)amino)methylJ-2-butoxybiphenyl-4- vDprooanoate In a manner analogous to Example 9g, by reaction of 500 mg (1.4 mmol, 1 eq.) of methyl 3-(2-butoxy-3'-(methylaminomethyl)biphenyl-4- yl)propanoate (prepared in Example 9f) and of 325 μl (2.80 mmol, 2 eq.) of benzoyl chloride in 10 ml of dichloromethane in the presence of 600 μl (4.3 mmol, 3 eq.) of triethylamine and of 17 mg (10 mol%) of 4-dimethylaminopyridine, 573 mg of methyl 3-{3'-[((benzoyl)(methyl)amino)methyl]-2-butoxybiphenyl-4- yljpropanoate are obtained in the form of a yellow oil. Yield = 89% b. 3-/3 '-[((Benzo yl) (meth yl) amino) met h yll-2-butoxybiphen yl-4- yl) propanoic acid 493 mg (12.3 mmol, 10 eq.) of sodium hydroxide are added to a solution of 566 mg (1.23 mmol, 1 eq.) of methyl 3-{3'- [((benzoyl)(methyl)amino)methyl]-2-butoxybiphenyl-4-yl}propa noate in 10 ml of methanol. The reaction mixture is heated at 500C for 2 hours. The reaction medium is evaporated to dryness, the residue is taken up in water, acidification is carried out with a 1 N hydrochloric acid solution and extraction is carried out with ethyl acetate. The organic phases are combined, washed with water and dried over magnesium sulphate. The solvent is evaporated and the product is crystallized in an ethyl ether/heptane mixture. 450 mg of 3-{3'- [((benzoyl)(methyl)amino)methyl]-2-butoxybiphenyl-4-yl}propa noic acid are obtained in the form of a white powder. (M. p. = 103-1050C) Yield = 82% 1H NMR (CDCk. 400 MHz): 0.87 (t, 3H), 1.38 (m, 2H)1 1.64-1.70 (m, 2H), 2.73 (t, 2H), 2.88 & 3.06 (2s e, 3H), 2.99 (t, 2H), 3.95 (t, 2H), 4.54 & 4.80 (2s (rotamers), 2H), 6.83 (S, 1 H), 6.87 (d, 1 H), 7.09-7.51 (m, 10H). Example 15; 3-(2-Butoxy-3'-m4- methoxybenzoyl)(methyl)amino1methyl}biphenyl-4-yl)propanoic acid

a. Methyl 3-(2-butoxy-3'-{f(4-methoxybenzoyl)(methyl)aminolmethyl)biDh enyl-4- vDpropanoate In a manner analogous to Example 9g, by reaction of 500 mg (1.4 mmol, 1 eq.) of methyl 3-(2-butoxy-3'-(methylaminomethyl)biphenyl-4- yl)propanoate (prepared in Example 9f) and of 386 μl (2.80 mmol, 2 eq.) of 4- methoxybenzoyl chloride in 10 ml of dichloromethane in the presence of 600 μl (4.3 mmol, 3 eq.) of triethylamine and of 17 mg (10 mol%) of 4-dimethylaminopyridine, 623 mg of methyl 3-(2-butoxy-3'-{[(4- methoxybenzoyl)(methyl)amino]methyl}biphenyl-4-yl)propanoate are obtained in the form of a yellow oil. Yield = 91% b. 3-(2-Butoxy-3'-ff(4-methoxybenzoyl)(methyl)aminolmethyl)biDh enyl-4- vDprooanoic acid In a manner analogous to Example 14b, by reaction of 503 mg (12.6 mmol, 10 eq.) of sodium hydroxide and of 616 mg (1.26 mmol, 1 eq.) of methyl 3-(2-butoxy-3'-{[(4-methoxybenzoyl)(methyl)amino]methyl}biph enyl-4- yl)propanoate, prepared in the preceding stage, in 10 ml of methanol, 470 mg of 3-(2-butoxy-3'-{[(4-methoxybenzoyl)(methyl)amino]methyl}biph enyl-4-yl)propanoic acid are obtained in the form of an amorphous solid. (M. p. = 39-410C) Yield = 79% 1H NMR (CDCK. 400 MHz): 0.87 (t, 3H), 1.33-1.42 (m, 2H), 1.64-1.71 (m, 2H), 2.73 (t, 2H), 2.99 (t & m, 5H), 3.81 (s, 3H), 3.95 (t, 2H), 4.60 & 4.75 (2m e, 2H), 6.83-6.89 (m, 4H), 7.23-7.46 (m, 7H). Example 16: 3-(2-Butoxy-3'-M3- methoxybenzoyl)(methyl)amino1methyl>biphenyl-4-yl)propano ic acid

a. Methyl 3-(2-butoxy-3'-{f(3-methoxybenzoyl)(methyl)aminolmethyl)biph enyl-4- vDprooanoate In a manner analogous to Example 9g, by reaction of 500 mg (1.4 mmol, 1 eq.) of methyl 3-(2-butoxy-3'-(methylaminomethyl)biphenyl-4- yl)propanoate (prepared in Example 9f) and of 393 μl (2.80 mmol, 2 eq.) of 3- methoxybenzoyl chloride in 10 ml of dichloromethane in the presence of 600 μl (4.3 mmol, 3 eq.) of triethylamine and of 17 mg (10 mol%) of 4-dimethylaminopyridine, 583 mg of methyl 3-(2-butoxy-3'-{[(3- methoxybenzoyl)(methyl)amino]methyl}biphenyl-4-yl)propanoate are obtained in the form of a yellow oil. Yield = 85% b, 3-(2-Butoxy-3 '-{[(3-methoxybenzo yl) (meth yl) aminolmeth vDbiohen yl-4- vDprooanoic acid In a manner analogous to Example 14b, by reaction of 471 mg (11.8 mmol, 10 eq.) of sodium hydroxide and of 576 mg (1.18 mmol, 1 eq.) of methyl 3-(2-butoxy-3'-{[(3-methoxybenzoyl)(methyl)amino]methyl}biph enyl-4- yl)propanoate, prepared in the preceding stage, in 10 ml of methanol, 384 mg of 3-(2-butoxy-3'-{[(3-methoxybenzoyl)(methyl)amino]methyl}biph enyl-4-yl)propanoic acid are obtained in the form of a white powder. (M. p. = 80-820C) Yield = 67% 1H NMR (CDCI.. 400 MHz): 0.88 (t, 3H), 1.37 (m, 2H), 1.67 (m, 2H), 2.73 (t, 2H), 2.88 & 3.07 (2s e, 3H), 2.99 (t, 2H), 3.69 & 3.82 (2s (rotamer, 3H), 3.94 (t, 2H), 4.53 & 4.79 (2s (rotamers), 2H), 6.83 (s, 1 H), 6.86 (d, 1 H), 6.93-7.22 (m, 4H), 7.30-7.50 (m, 5H).

EXAMPLE 17: CROSSED-CURVE PPAR TRANSACTIVATION ASSAY Activation of the PPAR receptors by an agonist (activator) in HeLN cells leads to the expression of a reporter gene, luciferase, which, in the presence of a substrate, generates light. The modulation of the PPAR receptors is measured by quantifying the luminescence produced after incubation of the cells in the presence of a reference agonist. The ligands will displace the agonist from its site. The measurement of the activity is performed by quantifying the light produced. This measurement makes it possible to determine the modulatory activity of the compounds according to the invention by the determination of the constant which represents the affinity of the molecule for the PPAR receptor. Since this value can fluctuate depending on the basal activity and the expression of the receptor, it is referred to as apparent Kd (Kdapp in nM). To determine this constant, "crossed curves" for the test product, against a reference agonist, are prepared using a 96-well plate: 10 concentrations of the test product plus a concentration 0 are arranged in a line, and 7 concentrations of the agonist plus a concentration 0 are arranged in a column. This represents 88 measurement points for 1 product and 1 receptor. The remaining 8 wells are used for repeatability controls. In each well, the cells are in contact with a concentration of the test product and a concentration of the reference agonist, 2-(4-{2-[3-(2,4-difluoro- phenyi)-1-heptylureido]ethyl}phenylsulphanyl)-2-methylpropio nic acid for PPARα, {2-methyl-4-[4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5 -ylmethylsulphanyl]- phenoxy}acetic acid for PPARδ and 5-{4-[2-(methyl(pyrid-2- yl)amino)ethoxy]benzyl}thiazolidine-2,4-dione for PPARγ. Measurements are also taken for total agonist controls with the same products. The HeLN cell lines used are stable transfectants containing the plasmids ERE-βGlob-Luc-SV-Neo (reporter gene) and PPAR (α, δ, γ) Gal-hPPAR. These cells are seeded in 96-well plates at the rate of 10 000 cells per well in 100 μl of DMEM medium without phenol red and supplemented with 10% of defatted calf serum. The plates are then incubated for 16 hours at 37°C and 7% CO2. The various dilutions of the test products and of the reference ligand are added at the rate of 5 μl per well. The plates are subsequently incubated for 18 hours at 37°C and 7% CO2. The culture medium is removed by turning over and 100 μl of a 1 :1 PBS/luciferin mixture are added to each well. After 5 minutes, the plates are read using the luminescence reader. These crossed curves make it possible to determine the AC50 values (concentration at which 50% activation is observed) of the reference ligand at various concentrations of test product. These AC50 values are used to calculate the Schild regression by plotting a straight line corresponding to the Schild equation ("Quantitation in Receptor Pharmacology", Terry P. Kenakin, Receptors and Channels, 2001, 7, 371-385) which allows the Kdapp values (in nM) to be obtained.

Transactivation results: n.a. means not active These results show the affinity of the compounds for PPAR receptors and more particularly the specificity of the affinity of the compounds of the invention for the PPARγ subtype, compared with the affinity of the compounds for the PPARα subtype or for the PPARδ subtype.

EXAMPLE 18: COMPOSITIONS Various practical formulations based on the compounds according to the invention are illustrated in this example. A- ORAL ROUTE (a) 0.2 g tablet - Compound of Example 1 0.001 g - Starch 0.114 g - Dicalcium phosphate 0.020 g - Silica 0.02O g - Lactose 0.030 g - Talc 0.01O g - Magnesium stearate 0.005 g (b) Suspension to be taken orally in 5 ml vials - Compound of Example 5 0.001 g - Glycerol 0.500 g - 70% Sorbitol 0.500 g - Sodium saccharinate 0.010 g - Methyl para-hydroxybenzoate 0.040 g - Flavouring q.s. - Purified water q.s. for 5 ml (c) 0.2 g tablet - Compound of Example 2 0.050 g - Lactose monohydrate 0.132 g - Crospovidone 0.007 g - Povidone 0.005 g - Aerosil 2000.004 g - Magnesium stearate 0.002 g (d) Suspension to be taken orally in 10 ml vials - Compound of Example 4 0.200 g - Glycerol 1.000 g - 70% Sorbitol 1.00O g - Sodium saccharinate 0.01O g - Methyl para-hydroxybenzoate 0.080 g - Flavouring q.s. - Purified water q .s. for 10 ml ICAL ROUTE (a) Salve - Compound of Example 6 0.020 g - lsopropyl myristate 81.70O g - Liquid petrolatum 9.10O g - Silica ("Aerosil 200", sold by Degussa) 9.18O g (b) Salve - Compound of Example 2 0.300 g - White petrolatum, pharmaceutical grade q- s. for 100 g (c) Nonionic water-in-oil cream - Compound of Example 1 0.100 g Mixture of emulsive lanolin alcohols, of waxes and of oils ("Anhydrous eucerin", sold by BDF) 39.900 g Methyl para-hydroxybenzoate 0.075 g Propyl para-hydroxybenzoate 0.075 g - Sterile demineralized water q. s. for 100 g (d) Lotion Compound of Example 3 0.100 g - Polyethylene glycol (PEG) 400 69.900 g - 95% Ethanol 30.000 g (e) Hydrophobic salve - Compound of Example 5 0.300 g - lsopropyl myristate 36.400 g - Silicone oil ("Rhodorsil 47 V 300", sold by Rhόne-Poulenc) 36.400 g - Beeswax 13.60O g - Silicone oil ("AbN 300,000 cSt", sold by Goldschmidt) q.s. for 100 g (f) Nonionic oil-in-water cream - Compound of Example 2 1.000 g - Cetyl alcohol 4.000 g - Glyceryl monostearate 2.50O g - PEG 50 stearate 2.500 g - Shea butter 9.200 g Propylene glycol 2.000 g Methyl para-hydroxybenzoate 0.075 g - Propyl para-hydroxybenzoate 0.075 g Sterile demineralized water q.s. for 100 g