Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NOVEL BIPHENYL COMPOUNDS AND THEIR USE
Document Type and Number:
WIPO Patent Application WO2006020358
Kind Code:
A3
Abstract:
The invention is directed to certain biphenyl compounds. Specifically, the invention is directed to compounds according to Formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and Y are as defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are KSP inhibitors, particularly human KSP inhibitors, and can be useful for the treatment for a variety of diseases and conditions, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders, fungal disorders, and inflammation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting KSP and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. In an additional aspect, the invention provides methods of screening for compounds that will bind to a KSP kinesin, for example compounds that will displace or compete with the binding of the compounds of the invention. The methods comprise combining a labeled compound of the invention, a KSP kinesin, and at least one candidate agent and determining the binding of the candidate bioactive agent to the KSP kinesin. In a further aspect, the invention provides methods of screening for modulators of KSP kinesin activity. The methods comprise combining a compound of the invention, a KSP kinesin, and at least one candidate agent and determining the effect of the candidate bioactive agent on the KSP kinesin activity.

Inventors:
CHAUDHARI AMITA M (US)
DHANAK DASHYANT (US)
KNIGHT STEVEN DAVID (US)
MORGANS DAVID J JR (US)
PARRISH CYNTHIA A (US)
Application Number:
US2005026214W
Publication Date:
December 28, 2006
Filing Date:
July 27, 2005
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
SMITHKLINE BEECHAM CORP (US)
CYTOKINETICS INC (US)
CHAUDHARI AMITA M (US)
DHANAK DASHYANT (US)
KNIGHT STEVEN DAVID (US)
MORGANS DAVID J JR (US)
PARRISH CYNTHIA A (US)
International Classes:
A61K31/335; A61K31/167; A61K31/17; C07C233/15; C07C275/28; C07C275/32; C07C275/40; C07C335/16; C07C335/20; C07D319/06
Foreign References:
Other References:
DATABASE CAPLUS [online] ADGER ET AL.: "Phenanthrideines. I. Synthesis of bromophenanthridines", XP008113816, accession no. STN Database accession no. (1957:51872)
See also references of EP 1778214A4
Download PDF: