Title:
NOVEL BISPECIFIC CD3/CD19 POLYPEPTIDE COMPLEXES
Document Type and Number:
WIPO Patent Application WO/2019/057124
Kind Code:
A1
Abstract:
A bispecific anti-CD3 x CD19 polypeptide complex that contains a first antigen-binding moiety of the polypeptide complex and a second antigen-binding moiety, methods of producing the bispecific anti-CD3 x CD19 polypeptide complex, methods of treating disease or disorder using the bispecific anti-CD3 x CD19 polypeptide complex, polynucleotides encoding the bispecific anti-CD3 x CD19 polypeptide complex, vectors and host cells containing said polynucleotides, and compositions and pharmaceutical compositions comprising the bispecific anti-CD3 x CD19 polypeptide complex are provided.
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Inventors:
LIU JIEYING (CN)
XU JIANQING (CN)
WANG ZHUOZHI (CN)
MEI QIN (CN)
LI JING (CN)
XU JIANQING (CN)
WANG ZHUOZHI (CN)
MEI QIN (CN)
LI JING (CN)
Application Number:
PCT/CN2018/106776
Publication Date:
March 28, 2019
Filing Date:
September 20, 2018
Export Citation:
Assignee:
WUXI BIOLOGICS SHANGHAI CO LTD (CN)
WUXI BIOLOGICS IRELAND LTD (IE)
WUXI BIOLOGICS IRELAND LTD (IE)
International Classes:
C07K16/28; A61K39/39; A61P35/00; C07K16/46
Domestic Patent References:
| WO2017055314A1 | 2017-04-06 | |||
| WO2016048938A1 | 2016-03-31 | |||
| WO2017053469A2 | 2017-03-30 |
Foreign References:
| CN104829726A | 2015-08-12 | |||
| CN101802015A | 2010-08-11 |
Other References:
ESHHAR, Z. ET AL.: "Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the y or zeta subunits of the immunoglobulin and T- cell receptors", PROC. NATL. ACAD. SCI. USA, vol. 90, no. 2, 31 January 1993 (1993-01-31), pages 720 - 724, XP002009770, DOI: doi:10.1073/pnas.90.2.720
KIPRIYANOV, S.M. ET AL.: "BISPECIFIC CD 3xCD19 DIABODY FOR T CELL - MEDIATED LYSIS OF MALIGNANT HUMAN B CELLS", INT.J.CANCER, vol. 77, no. 5, 31 December 1998 (1998-12-31), pages 763 - 772, XP002932518, DOI: doi:10.1002/(SICI)1097-0215(19980831)77:5<763::AID-IJC16>3.0.CO;2-2
WU, J.J. ET AL.: "Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD 19/ CD 3 for refractory acute lymphoid leukemia", JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 8, 31 December 2015 (2015-12-31), pages 1 - 7, XP002764048, DOI: doi:10.1186/s13045-015-0195-4
GOVERMAN, J. ET AL.: "Chimeric Immunoglobulin-T Cell Receptor Proteins Form Functional Receptors: Implications for T Cell Receptor Complex Formation and Activation", CELL, vol. 60, 23 March 1990 (1990-03-23), pages 929 - 939, XP023908129, DOI: doi:10.1016/0092-8674(90)90341-B
HUEHLS, A.M. ET AL.: "Bispecific T cell engagers for cancer immunotherapy", IMMUNOL CELL BIOL., vol. 93, no. 3, 31 March 2015 (2015-03-31), pages 290 - 296, XP055537601, DOI: doi:10.1038/icb.2014.93
See also references of EP 3684817A4
KIPRIYANOV, S.M. ET AL.: "BISPECIFIC CD 3xCD19 DIABODY FOR T CELL - MEDIATED LYSIS OF MALIGNANT HUMAN B CELLS", INT.J.CANCER, vol. 77, no. 5, 31 December 1998 (1998-12-31), pages 763 - 772, XP002932518, DOI: doi:10.1002/(SICI)1097-0215(19980831)77:5<763::AID-IJC16>3.0.CO;2-2
WU, J.J. ET AL.: "Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD 19/ CD 3 for refractory acute lymphoid leukemia", JOURNAL OF HEMATOLOGY & ONCOLOGY, vol. 8, 31 December 2015 (2015-12-31), pages 1 - 7, XP002764048, DOI: doi:10.1186/s13045-015-0195-4
GOVERMAN, J. ET AL.: "Chimeric Immunoglobulin-T Cell Receptor Proteins Form Functional Receptors: Implications for T Cell Receptor Complex Formation and Activation", CELL, vol. 60, 23 March 1990 (1990-03-23), pages 929 - 939, XP023908129, DOI: doi:10.1016/0092-8674(90)90341-B
HUEHLS, A.M. ET AL.: "Bispecific T cell engagers for cancer immunotherapy", IMMUNOL CELL BIOL., vol. 93, no. 3, 31 March 2015 (2015-03-31), pages 290 - 296, XP055537601, DOI: doi:10.1038/icb.2014.93
See also references of EP 3684817A4
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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