Title:
NOVEL BUTANE-TETRAOL-BASED AMPHIPATHIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/030602
Kind Code:
A1
Abstract:
The present invention relates to: a novelly developed butane-tetraol-based amphipathic compound; a preparation method therefor; and a method for extracting, solubilizing, stabilizing, crystallizing, or analyzing membrane proteins by using the same. A chiral core structure is present in the butane-tetraol-based compound according to the present invention, and a clear difference has been discovered in the characteristics of isomers according to the stereochemistry of the core structure, and thus an appropriate compound suitable for a use can be selected. In addition, compared to a conventional compound, the compound can effectively extract membrane proteins having various structures and characteristics from cell membranes, and stably store the same in an aqueous solution for a long time, thereby being usable in the functional analysis and structural analysis of the same. Because of a close relationship with the development of new drugs, structural and functional analysis of membrane proteins is one of fields that currently receives the most attention in biology and chemistry.
Inventors:
CHAE PIL SEOK (KR)
DAS MANABENDRA (KR)
DAS MANABENDRA (KR)
Application Number:
PCT/KR2017/001478
Publication Date:
February 15, 2018
Filing Date:
February 10, 2017
Export Citation:
Assignee:
IUCF HYU ERICA CAMPUS (KR)
International Classes:
C07H15/04; C07K1/14; C07K14/705
Foreign References:
| US5811405A | 1998-09-22 | |||
| EP0671408A2 | 1995-09-13 |
Other References:
DATABASE Chemical abstract compoun [O] 28 September 2008 (2008-09-28), XP055462543, retrieved from STN Database accession no. 1053747-71-9
VAINO, A. R. ET AL.: "Synthesis of 1,2,3-tri-O-beta-lactosyl-D-threitol and 1-O-Benzyl-2,3,4-tri-O-beta-lactosyl-D-threitol", CARBOHYDRATE RESEARCH, vol. 305, no. 1, 1998, pages 27 - 31, XP004110789
EHSAN, M. ET AL.: "Highly Branched Pentasaccharide-bearing Amphiphiles for Membrane Protein Studies", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 138, no. 1 1, 11 March 2016 (2016-03-11), pages 3789 - 3796, XP055462432
DAS, M. ET AL.: "Butane-1,2,3,4-tetraol-based Amphiphilic Stereoisomers for Membrane Protein Study: Importance of Chirality in the Linker Region", CHEMICAL SCIENCE, vol. 8, 5 October 2016 (2016-10-05), pages 1169 - 1177, XP055462433
DAS, M. ET AL.: "Comparative Study on Diastereomeric Amphiphiles for Membrane Protein Study", PROCEEDINGS OF KCS 117TH GENERAL MEETINGS, vol. 56, no. 4, 20 April 2016 (2016-04-20), XP055462435
VAINO, A. R. ET AL.: "Synthesis of 1,2,3-tri-O-beta-lactosyl-D-threitol and 1-O-Benzyl-2,3,4-tri-O-beta-lactosyl-D-threitol", CARBOHYDRATE RESEARCH, vol. 305, no. 1, 1998, pages 27 - 31, XP004110789
EHSAN, M. ET AL.: "Highly Branched Pentasaccharide-bearing Amphiphiles for Membrane Protein Studies", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 138, no. 1 1, 11 March 2016 (2016-03-11), pages 3789 - 3796, XP055462432
DAS, M. ET AL.: "Butane-1,2,3,4-tetraol-based Amphiphilic Stereoisomers for Membrane Protein Study: Importance of Chirality in the Linker Region", CHEMICAL SCIENCE, vol. 8, 5 October 2016 (2016-10-05), pages 1169 - 1177, XP055462433
DAS, M. ET AL.: "Comparative Study on Diastereomeric Amphiphiles for Membrane Protein Study", PROCEEDINGS OF KCS 117TH GENERAL MEETINGS, vol. 56, no. 4, 20 April 2016 (2016-04-20), XP055462435
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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