Title:
NOVEL CARBONATE COMPOUND HAVING PYRROLOPYRIMIDINE SKELETON OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/255979
Kind Code:
A1
Abstract:
[Problem] To provide: a novel carbonate compound of nucleotides which has a pyrrolopyrimidine skeleton and exhibits an excellent antitumor effect, or a pharmaceutically acceptable salt thereof; and a method for preventing and/or treating tumor by being used in combination with an alkylating agent and/or radiotherapy. [Solution] According to an aspect of the present invention, provided are: a compound represented by general formula (1) or a pharmaceutically acceptable salt; and a method for preventing and/or treating tumor by being used in combination with an alkylating agent and/or radiotherapy.
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Inventors:
MIYAKOSHI HITOSHI (JP)
TANAKA NOZOMU (JP)
KOBAYAKAWA YU (JP)
TANAKA NOZOMU (JP)
KOBAYAKAWA YU (JP)
Application Number:
PCT/JP2020/023661
Publication Date:
December 24, 2020
Filing Date:
June 17, 2020
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
International Classes:
A61P35/00; A61K31/7064; C07H19/14
Domestic Patent References:
| WO2014124430A1 | 2014-08-14 | |||
| WO2018085307A1 | 2018-05-11 | |||
| WO2004041203A2 | 2004-05-21 | |||
| WO2004041203A2 | 2004-05-21 | |||
| WO2013009735A1 | 2013-01-17 |
Foreign References:
| JP2009543884A | 2009-12-10 |
Other References:
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SEELA, FRANK, CHITTEPU PADMAJA, EICKMEIER HENNING: "4-Amino-7-(2-deoxy-2-fluoro-β- D -arabinofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine: a bis-fluorinated analogue of 2′-deoxytubercidin", ACTA CRYSTALLOGRAPHICA, vol. C62, no. 4, 2006, pages o231 - o233, XP055774474, DOI: 10.1107/S0108270106007633
LI, WEI, YANG RUCHUN, XIAO QIANG: "(2R,3S,4R,5R)-5-(4-Amino-5-iodo-7H-pyrrolo-[2,3-d]pyrimidin-7-yl)-4-fluoro-2-(hy-droxy-meth-yl)tetra-hydro-furan-3-ol", ACTA CRYSTALLOGRAPHICA, vol. 70, no. 2, 2014, pages 1 - 7, XP055774480, Retrieved from the Internet DOI: 10.1107/S1600536813034995
SEELA, FRANK, XU KUIYING: "DNA with stable fluorinated dA and dG substitutes: syntheses, base pairing and 19F-NMR spectra of 7-fluoro-7-deaza-2 -deoxyadenosine and 7-fluoro-7-deaza-2 -deoxyguanosine", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 6, no. 19, 2008, pages 3552 - 3560, XP055774483, DOI: 10.1039/ b806145a
NAUS, PETR; PAVLA PERLÍKOVÁ; AURELIE BOURDERIOUX; RADEK POHL; LENKA SLAVĚTÍNSKÁ; IVAN VOTRUBA; GINA BAHADOR; GABRIEL BIRKUŠ; TOMÁŠ: "Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′-fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, no. 17, 2012, pages 5202 - 5214, XP055496940, DOI: 10.1016/j.bmc.2012.07.003
SEELA, FRANK, CHITTEPU PADMAJA, HE YANG, HE JUNLIN, XU KUIYING: "6-AZAPYRIMIDINE AND 7-DEAZAPURINE 2′-DEOXY-2′-FLUOROARABINONUCLEOSIDES: SYNTHESIS, CONFORMATION AND PROPERTIES OF OLIGONUCLEOTIDES", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 24, no. 5-7, 2005, pages 847 - 850, XP055774491, DOI: DOI 10.1081/NCN-200059181
LARSEN, CLOUS S. ET AL.: "Chapter 14 Design and application of prodrugs", TEXTBOOK OF DRUG DESIGN AND DISCOVERY, 2002, pages 460 - 514, XP055530665
CAS, no. 145388-61-0
DRUG METAB DISPOS, vol. 30, no. 11, November 2002 (2002-11-01), pages 1221 - 1229
J. ORG. CHEM., vol. 64, no. 22, 1999, pages 8319 - 8322
ACTA CRYST., vol. E70, 2014, pages ol20
CHEMMEDCHEM, vol. 8, 2013, pages 832 - 846
BIOORG. MED. CHEM, vol. 20, 2012, pages 5202 - 5214
J MED CHEM, vol. 59, no. 14, 2016, pages 6860 - 6877
SYNTHESIS, no. 5, 1992, pages 477 - 481
GREENEWUTS: "Protective Groups in Organic Synthesis", 2014, JOHN WILEY & SONS INC.
LABIO, vol. 21, no. 30, October 2007 (2007-10-01), pages 27
SEELA, FRANK, CHITTEPU PADMAJA, EICKMEIER HENNING: "4-Amino-7-(2-deoxy-2-fluoro-β- D -arabinofuranosyl)-5-fluoro-7H-pyrrolo[2,3-d]pyrimidine: a bis-fluorinated analogue of 2′-deoxytubercidin", ACTA CRYSTALLOGRAPHICA, vol. C62, no. 4, 2006, pages o231 - o233, XP055774474, DOI: 10.1107/S0108270106007633
LI, WEI, YANG RUCHUN, XIAO QIANG: "(2R,3S,4R,5R)-5-(4-Amino-5-iodo-7H-pyrrolo-[2,3-d]pyrimidin-7-yl)-4-fluoro-2-(hy-droxy-meth-yl)tetra-hydro-furan-3-ol", ACTA CRYSTALLOGRAPHICA, vol. 70, no. 2, 2014, pages 1 - 7, XP055774480, Retrieved from the Internet
SEELA, FRANK, XU KUIYING: "DNA with stable fluorinated dA and dG substitutes: syntheses, base pairing and 19F-NMR spectra of 7-fluoro-7-deaza-2 -deoxyadenosine and 7-fluoro-7-deaza-2 -deoxyguanosine", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 6, no. 19, 2008, pages 3552 - 3560, XP055774483, DOI: 10.1039/ b806145a
NAUS, PETR; PAVLA PERLÍKOVÁ; AURELIE BOURDERIOUX; RADEK POHL; LENKA SLAVĚTÍNSKÁ; IVAN VOTRUBA; GINA BAHADOR; GABRIEL BIRKUŠ; TOMÁŠ: "Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′-fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 20, no. 17, 2012, pages 5202 - 5214, XP055496940, DOI: 10.1016/j.bmc.2012.07.003
SEELA, FRANK, CHITTEPU PADMAJA, HE YANG, HE JUNLIN, XU KUIYING: "6-AZAPYRIMIDINE AND 7-DEAZAPURINE 2′-DEOXY-2′-FLUOROARABINONUCLEOSIDES: SYNTHESIS, CONFORMATION AND PROPERTIES OF OLIGONUCLEOTIDES", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 24, no. 5-7, 2005, pages 847 - 850, XP055774491, DOI: DOI 10.1081/NCN-200059181
LARSEN, CLOUS S. ET AL.: "Chapter 14 Design and application of prodrugs", TEXTBOOK OF DRUG DESIGN AND DISCOVERY, 2002, pages 460 - 514, XP055530665
CAS, no. 145388-61-0
DRUG METAB DISPOS, vol. 30, no. 11, November 2002 (2002-11-01), pages 1221 - 1229
J. ORG. CHEM., vol. 64, no. 22, 1999, pages 8319 - 8322
ACTA CRYST., vol. E70, 2014, pages ol20
CHEMMEDCHEM, vol. 8, 2013, pages 832 - 846
BIOORG. MED. CHEM, vol. 20, 2012, pages 5202 - 5214
J MED CHEM, vol. 59, no. 14, 2016, pages 6860 - 6877
SYNTHESIS, no. 5, 1992, pages 477 - 481
GREENEWUTS: "Protective Groups in Organic Synthesis", 2014, JOHN WILEY & SONS INC.
LABIO, vol. 21, no. 30, October 2007 (2007-10-01), pages 27
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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