Title:
NOVEL CATECHOL DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, USE OF THE CATECHOL DERIVATIVE AND USE OF THE PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2010/001821
Kind Code:
A1
Abstract:
Disclosed are a compound represented by general formula (I) (wherein R1 and R2 each represents a hydrogen, a lower acyl, a lower alkoxycarbonyl or the like; R3 represents a lower alkyl, a halogenated lower alkyl, a cycloalkyl, a heterocycloalkyl, an optionally substituted aryl, an optionally substituted heteroaryl or the like; and R4 represents a cyano, a lower alkoxycarbonyl, a carboxy or the like) having a strong COMT inhibitory activity or a pharmacologically acceptable salt thereof, a pharmaceutical composition containing the compound or a salt thereof, and uses of the compound, the salt and the composition.
Inventors:
ISHIKAWA TAKEHIRO (JP)
KOBAYASHI SATOKO (JP)
INOUE HITOSHI (JP)
UENO YASUNORI (JP)
YOSHIDA MASAKO (JP)
TANAKA NOBUYUKI (JP)
KOBAYASHI SATOKO (JP)
INOUE HITOSHI (JP)
UENO YASUNORI (JP)
YOSHIDA MASAKO (JP)
TANAKA NOBUYUKI (JP)
Application Number:
PCT/JP2009/061685
Publication Date:
January 07, 2010
Filing Date:
June 26, 2009
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
ISHIKAWA TAKEHIRO (JP)
KOBAYASHI SATOKO (JP)
INOUE HITOSHI (JP)
UENO YASUNORI (JP)
YOSHIDA MASAKO (JP)
TANAKA NOBUYUKI (JP)
ISHIKAWA TAKEHIRO (JP)
KOBAYASHI SATOKO (JP)
INOUE HITOSHI (JP)
UENO YASUNORI (JP)
YOSHIDA MASAKO (JP)
TANAKA NOBUYUKI (JP)
International Classes:
C07C205/61; A61K31/192; A61K31/24; A61K31/277; A61K31/351; A61K31/381; A61K31/40; A61K31/42; A61K31/425; A61K31/4453; A61K31/495; A61K31/5375; A61K31/55; A61P9/12; A61P25/16; A61P25/24; A61P43/00; C07C255/56; C07C255/57; C07D261/08; C07D277/24; C07D295/10; C07D309/06; C07D333/22
Domestic Patent References:
WO2001098250A1 | 2001-12-27 |
Foreign References:
JP2004501129A | 2004-01-15 | |||
JP2008308494A | 2008-12-25 | |||
EP0237929A1 | 1987-09-23 | |||
GB2200109A | 1988-07-27 |
Other References:
VICTOR BEHAR ET AL.: "Total Synthesis of the Novel Benzopentathiepin Varacinium Trifluoroacetate: The Viability of "Varacin Free Base"", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 115, no. 15, 1993, pages 7017 - 7018, XP008141182
S. V. ESWARAN ET AL.: "The Unusual Formation of Methyl a-(5,6-Dimethoxycarbonyl-2, 3-Dimethoxyazepin-7-ylidene)-a-[5- methoxycarbonyl-2,3-dimethoxypyrid-6-yl)acetate During the Pyrolysis of "Azido-meta-hemipinate"", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 33, no. 4, 1996, pages 1333 - 1337, XP008141179
See also references of EP 2305633A4
NUTT J.G. ET AL., LANCET, vol. 351, no. 9111, 1998, pages 1221 - 1222
EKLOF A.C. ET AL., KIDNEY INT., vol. 52, no. 3, 1997, pages 742 - 747
MOREAU J.L. ET AL., BEHAV. PHARMACOL., vol. 5, no. 3, 1994, pages 344 - 350
BENABOU R. ET AL., EXPERT OPIN. DRUG SAF., vol. 2, no. 3, 2003, pages 263 - 267
FORSBERGM. ET AL., J. PHARMACOL. EXP. THER., vol. 304, no. 2, 2003, pages 498 - 506
KOGA K. ET AL., EUR. J. PHARMACOL., vol. 408, 2000, pages 249 - 255
G. ZURCHER ET AL., J. NEUROCHEM., vol. 38, 1982, pages 191 - 195
G. ZFRCHER ET AL., J. NEUROCHEM., vol. 38, 1982, pages 191 - 195
S. V. ESWARAN ET AL.: "The Unusual Formation of Methyl a-(5,6-Dimethoxycarbonyl-2, 3-Dimethoxyazepin-7-ylidene)-a-[5- methoxycarbonyl-2,3-dimethoxypyrid-6-yl)acetate During the Pyrolysis of "Azido-meta-hemipinate"", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 33, no. 4, 1996, pages 1333 - 1337, XP008141179
See also references of EP 2305633A4
NUTT J.G. ET AL., LANCET, vol. 351, no. 9111, 1998, pages 1221 - 1222
EKLOF A.C. ET AL., KIDNEY INT., vol. 52, no. 3, 1997, pages 742 - 747
MOREAU J.L. ET AL., BEHAV. PHARMACOL., vol. 5, no. 3, 1994, pages 344 - 350
BENABOU R. ET AL., EXPERT OPIN. DRUG SAF., vol. 2, no. 3, 2003, pages 263 - 267
FORSBERGM. ET AL., J. PHARMACOL. EXP. THER., vol. 304, no. 2, 2003, pages 498 - 506
KOGA K. ET AL., EUR. J. PHARMACOL., vol. 408, 2000, pages 249 - 255
G. ZURCHER ET AL., J. NEUROCHEM., vol. 38, 1982, pages 191 - 195
G. ZFRCHER ET AL., J. NEUROCHEM., vol. 38, 1982, pages 191 - 195
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