Title:
NOVEL CATIONIC LIPID COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/035652
Kind Code:
A1
Abstract:
The present invention relates to a lipid compound having the structure of the following formula I, or a salt thereof, or an isomer thereof, or an N-oxide thereof, capable of being used alone or in combination with other lipid components, such as neutral lipids, steroids, and/or polymer conjugated lipids, to form lipid nanoparticles for delivering therapeutic agents and/or prophylactic agents such as nucleic acids. Further provided is a method for treating and/or preventing various diseases by using such lipid nanoparticles.
Inventors:
HUANG CAIGU (CN)
WANG SHUAI (CN)
HUANG TIEQIANG (CN)
WANG SHUAI (CN)
HUANG TIEQIANG (CN)
Application Number:
PCT/CN2022/093196
Publication Date:
March 16, 2023
Filing Date:
May 17, 2022
Export Citation:
Assignee:
GUANGZHOU ANOVENT PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C211/00; A61K9/127; A61K9/51; A61K47/14; C07B59/00; C07C219/02; C12N15/11
Domestic Patent References:
| WO2020252589A1 | 2020-12-24 |
Foreign References:
| CN103153347A | 2013-06-12 | |||
| CN111315359A | 2020-06-19 | |||
| CN110520409A | 2019-11-29 | |||
| CN105085292A | 2015-11-25 | |||
| CN102361650A | 2012-02-22 | |||
| CN102245590A | 2011-11-16 | |||
| US20200131116A1 | 2020-04-30 |
Other References:
MUTHUSAMY JAYARAMAN, STEVEN M. ANSELL, BARBARA L. MUI, YING K. TAM, JIANXIN CHEN, XINYAO DU, DAVID BUTLER, LAXMAN ELTEPU, SHIGEO M: "Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, ¬VERLAG CHEMIE| :, vol. 51, no. 34, 20 August 2012 (2012-08-20), pages 8529 - 8533, XP055063645, ISSN: 14337851, DOI: 10.1002/anie.201203263
SEBASTIANI FEDERICA, YANEZ ARTETA MARIANNA, LERCHE MICHAEL, PORCAR LIONEL, LANG CHRISTIAN, BRAGG RYAN A., ELMORE CHARLES S., KRISH: "Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 15, no. 4, 27 April 2021 (2021-04-27), US , pages 6709 - 6722, XP055896220, ISSN: 1936-0851, DOI: 10.1021/acsnano.0c10064
SEBASTIANI FEDERICA, YANEZ ARTETA MARIANNA, LERCHE MICHAEL, PORCAR LIONEL, LANG CHRISTIAN, BRAGG RYAN A., ELMORE CHARLES S., KRISH: "Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles", ACS NANO, AMERICAN CHEMICAL SOCIETY, US, vol. 15, no. 4, 27 April 2021 (2021-04-27), US , pages 6709 - 6722, XP055896220, ISSN: 1936-0851, DOI: 10.1021/acsnano.0c10064
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