NOVEL CATIONIC LIPID HAVING CYSTINE SKELETON

Title:

NOVEL CATIONIC LIPID HAVING CYSTINE SKELETON

Document Type and Number:

WIPO Patent Application WO/2021/193397

Kind Code:

A1

Abstract:

The present invention provides a cationic lipid represented by formula (1) (wherein each symbol is as defined in the description), a lipid membrane structure using the cationic lipid, a nucleic acid transfection agent using the cationic lipid, and a method of nucleic acid transfection using the nucleic acid transfection agent.

Inventors:

TAMAGAWA SHINYA (JP)
TANGE KOTA (JP)
NAKAI YUTA (JP)
TAMADA MASAMICHI (JP)
AKITA HIDETAKA (JP)
TANAKA HIROKI (JP)
SAKURAI YU (JP)

Application Number:

PCT/JP2021/011298

Publication Date:

September 30, 2021

Filing Date:

March 19, 2021

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Assignee:

NOF CORP (JP)
UNIV CHIBA NAT UNIV CORP (JP)

International Classes:

C12N15/87; A61K9/50; A61K47/54; A61K48/00; C07C321/20

Domestic Patent References:

WO2013050547A1	2013-04-11
WO2016121942A1	2016-08-04
WO2019188867A1	2019-10-03

Foreign References:

RU2233834C2	2004-08-10
US9708628B2	2017-07-18
US20180298379A1	2018-10-18
JP2020057383A	2020-04-09

Other References:

BIOMATERIALS, vol. 29, no. 24-25, 2008, pages 3477 - 96
MOLECULAR THERAPY, vol. 24, no. 4, 2016, pages 788 - 795
ANGEWANTE CHEMIE INTERNATIONAL EDITION, vol. 51, 2012, pages 8529 - 8533
MOLECULAR THERAPY, vol. 13, no. 4, 2006, pages 786 - 794
"GREENE'S PROTECTIVE GROUPS IN ORGANIC SYNTHESIS", WILEY-INTERSCIENCEM

Attorney, Agent or Firm:

TAKASHIMA, Hajime (JP)

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