Title:
NOVEL COCRYSTAL OF EMPAGLIFLOZIN
Document Type and Number:
WIPO Patent Application WO/2021/137369
Kind Code:
A1
Abstract:
As a result of efforts to improve the problems of empagliflozin, that is, low stability and water solubility, an empagliflozin cocrystal having at least 120-fold increase in stability and water solubility was developed. The empagliflozin cocrystal according to the present invention is in a novel solid form that overcomes the stability and water solubility of known crystalline forms of empagliflozin, and is very useful as an optimal active pharmaceutical ingredient that can be maximally utilized as a drug.
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Inventors:
AN JI HUN (KR)
Application Number:
PCT/KR2020/008488
Publication Date:
July 08, 2021
Filing Date:
June 29, 2020
Export Citation:
Assignee:
UNICEL LAB CO LTD (KR)
International Classes:
C07H15/26; A61K31/7048; A61P3/10
Foreign References:
| US20180362514A1 | 2018-12-20 | |||
| CN105524033A | 2016-04-27 | |||
| KR101811997B1 | 2017-12-26 | |||
| US20170158659A1 | 2017-06-08 | |||
| KR102111248B1 | 2020-05-14 |
Other References:
MASCITTI VINCENT, THUMA BENJAMIN A., SMITH AARON C., ROBINSON RALPH P., BRANDT THOMAS, KALGUTKAR AMIT S., MAURER TRISTAN S., SAMAS: "On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin", MEDCHEMCOMM, ROYAL SOCIETY OF CHEMISTRY, UNITED KINGDOM, vol. 4, no. 1, 1 January 2013 (2013-01-01), United Kingdom, pages 101 - 111, XP055826455, ISSN: 2040-2503, DOI: 10.1039/C2MD20163A
Attorney, Agent or Firm:
JHO, Hyun Joong (KR)
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