Title:
NOVEL COMPOUND ISOLATED FROM PLANT "PAU-FERRO"
Document Type and Number:
WIPO Patent Application WO/2007/097455
Kind Code:
A1
Abstract:
Active ingredients contained in the stem of "Pau-Ferro", a plant belonging to the family Leguminosae, the genus Caesalpiniaceae inhabiting in Middle and South America are isolated, and are examined with respect to the inhibitory effect on type II DNA topoisomerase. As a result, it is found that an extract from the plant "Pau-Ferro" is excellent in type II DNA topoisomerase inhibiting activity, cell growth inhibiting activity and apoptosis inducing activity and therefore is useful as a therapeutic or prophylactic agent for various cancerous diseases.
Inventors:
NOZAKI HIROSHI (JP)
YAMADA MASASHI (JP)
SUZUKI HIROTO (JP)
SUMA YUKIE (JP)
ISHII MANABU (JP)
YAMADA MASASHI (JP)
SUZUKI HIROTO (JP)
SUMA YUKIE (JP)
ISHII MANABU (JP)
Application Number:
PCT/JP2007/053614
Publication Date:
August 30, 2007
Filing Date:
February 27, 2007
Export Citation:
Assignee:
MEIJI DAIRIES CORP (JP)
NOZAKI HIROSHI (JP)
YAMADA MASASHI (JP)
SUZUKI HIROTO (JP)
SUMA YUKIE (JP)
ISHII MANABU (JP)
NOZAKI HIROSHI (JP)
YAMADA MASASHI (JP)
SUZUKI HIROTO (JP)
SUMA YUKIE (JP)
ISHII MANABU (JP)
International Classes:
C07D307/80; A61K31/343; A61K31/353; A61P35/00; A61P35/02; A61P43/00; C07D493/04
Foreign References:
| JPH1135569A | 1999-02-09 | |||
| JP2004528296A | 2004-09-16 |
Other References:
KAKUMOTO K. ET AL.: "Mame Ka Caesalpinia ferrea Mart. no Topoisomerase Sogai Kassei Polyphenol Yudotai", 2004 NEN CSJ: THE CHEMICAL SOCIETY OF JAPAN NISHI NIPPON TAIKAI KOEN YOKOSHU, 30 October 2004 (2004-10-30), pages 259, XP003017273
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (1-1-1 Oroshi-machi, Tsuchiura-sh, Ibaraki 47, JP)
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