Title:
NOVEL COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING SAME FOR TREATING OR PREVENTING NEURAL DAMAGE, NEURAL DISEASE, OR DEVELOPMENTAL DISORDER THROUGH PROMOTING PROLIFERATION, DIFFERENTIATION, AND/OR REGENERATION OF NEURAL CELLS
Document Type and Number:
WIPO Patent Application WO/2021/251551
Kind Code:
A1
Abstract:
The present invention relates to a compound of formula 1 and a pharmaceutical composition containing same. This compound may be useful as: a therapeutic agent for degenerative brain diseases including dementia or cranial nerve diseases and developmental disorders caused by neural cell damage, various degenerative neural diseases, ischemic nerve diseases, or neural damage diseases; a learning ability-improving agent; and a cognitive function-improving agent. [Formula 1] in formula 1 above, B represents a part derived from retinoic acid.
Inventors:
CHANG SHA JOUNG (KR)
KIM YEOUN HEE (KR)
LEE JUNG JIN (KR)
CHOI GA RAM (KR)
CHANG YONG MIN (KR)
KIM YEOUN HEE (KR)
LEE JUNG JIN (KR)
CHOI GA RAM (KR)
CHANG YONG MIN (KR)
Application Number:
PCT/KR2020/011305
Publication Date:
December 16, 2021
Filing Date:
August 25, 2020
Export Citation:
Assignee:
MIRAEBIOPHARM (KR)
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
International Classes:
C07D257/02; A61K31/395; A61P25/00; A61P25/28
Foreign References:
| US20100322855A1 | 2010-12-23 | |||
| JP2012504131A | 2012-02-16 | |||
| KR20180081558A | 2018-07-16 |
Other References:
SIMONETTA GENINATTI CRICH; CLAUDIA CABELLA; ALESSANDRO BARGE; SIMONA BELFIORE; CRISTINA GHIRELLI; LUCIANO LATTUADA; STEFANIA LANZA: "In vitro and in vivo magnetic resonance detection of tumor cells by targeting glutamine transporters with Gd-based probes", JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, no. 16, 1 January 2006 (2006-01-01), pages 4926 - 4936, XP008153001, ISSN: 0022-2623, DOI: 10.1021/jm0601093
HYUN-PIL LEE , GEMMA CASADESUS , XIONGWEI ZHU , HYOUNG-GON LEE , GEORGE PERRY , MARK A SMITH , KATARZYNA GUSTAW ROTHENBERG , ALAN : "All-Trans-Retinoic Acid as a Novel Therapeutic Strategy for Alzheimer`s Disease", EXPERT REVIEW OF NEUROTHERAPEUTICS, vol. 9, no. 11, 1 November 2009 (2009-11-01), GB , pages 1615 - 1621, XP009532746, ISSN: 1473-7175, DOI: 10.1586/ern.09.86
HYUN-PIL LEE , GEMMA CASADESUS , XIONGWEI ZHU , HYOUNG-GON LEE , GEORGE PERRY , MARK A SMITH , KATARZYNA GUSTAW ROTHENBERG , ALAN : "All-Trans-Retinoic Acid as a Novel Therapeutic Strategy for Alzheimer`s Disease", EXPERT REVIEW OF NEUROTHERAPEUTICS, vol. 9, no. 11, 1 November 2009 (2009-11-01), GB , pages 1615 - 1621, XP009532746, ISSN: 1473-7175, DOI: 10.1586/ern.09.86
Attorney, Agent or Firm:
NAM, Gun Pil et al. (KR)
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