Title:
NOVEL COMPOUND OR SALT THEREOF, AND ANTITUMOR ACTIVATOR CONTAINING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2022/190915
Kind Code:
A1
Abstract:
Provided are: a novel compound having improved in-vivo efficacy and antitumor activity of a curcumin derivative, or a salt thereof; and an antitumor activator containing the same as an active ingredient. The present invention is a compound represented by the following formula or a salt thereof. R1-R4 are each a hydrogen atom or a substituent selected from among a C1-4 lower alkyl group, a hydroxy C1-4 lower alkyl group, a C1-4 lower alkoxy C1-4 lower alkyl group, and a C1-4 lower alkoxy C1-4 lower alkoxy C1-4 lower alkyl group, and R1-R4 may be the same as or different from each other. n is 1-6. Sugar is a monosaccharide or a disaccharide.
Inventors:
SHIBATA HIROYUKI (JP)
IWABUCHI YOSHIHARU (JP)
IWABUCHI YOSHIHARU (JP)
Application Number:
PCT/JP2022/008078
Publication Date:
September 15, 2022
Filing Date:
February 25, 2022
Export Citation:
Assignee:
UNIV AKITA (JP)
UNIV TOHOKU (JP)
UNIV TOHOKU (JP)
International Classes:
C07H19/056; A61K31/7056; A61P35/00
Domestic Patent References:
| WO2007000998A1 | 2007-01-04 |
Other References:
MURAKAMI MEGUMI, OHNUMA SHINOBU, FUKUDA MICHIHIRO, CHUFAN EDUARDO E., KUDOH KATSUYOSHI, KANEHARA KEIGO, SUGISAWA NORIHIKO, ISHIDA : "Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance–Linked ATP-Binding Cassette Transporter ABCG2", DRUG METABOLISM AND DISPOSITION, PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 45, no. 11, 1 November 2017 (2017-11-01), US , pages 1166 - 1177, XP055965290, ISSN: 0090-9556, DOI: 10.1124/dmd.117.076000
KOHYAMA AKI, FUKUDA MICHIHIRO, SUGIYAMA SHUNSUKE, YAMAKOSHI HIROYUKI, KANOH NAOKI, ISHIOKA CHIKASHI, SHIBATA HIROYUKI, IWABUCHI YO: "Reversibility of the thia-Michael reaction of cytotoxic C 5 -curcuminoid and structure–activity relationship of bis-thiol-adducts thereof", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 14, no. 45, 1 January 2016 (2016-01-01), pages 10683 - 10687, XP055965288, ISSN: 1477-0520, DOI: 10.1039/C6OB01771A
CAGNONI ALEJANDRO J., VARELA OSCAR, GOUIN SÉBASTIEN G., KOVENSKY JOSÉ, UHRIG MARÍA LAURA: "Synthesis of Multivalent Glycoclusters from 1-Thio-β-D-galactose and Their Inhibitory Activity against the β-Galactosidase from E. coli", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 76, no. 9, 6 May 2011 (2011-05-06), pages 3064 - 3077, XP055965286, ISSN: 0022-3263, DOI: 10.1021/jo102421e
KOHYAMA AKI, FUKUDA MICHIHIRO, SUGIYAMA SHUNSUKE, YAMAKOSHI HIROYUKI, KANOH NAOKI, ISHIOKA CHIKASHI, SHIBATA HIROYUKI, IWABUCHI YO: "Reversibility of the thia-Michael reaction of cytotoxic C 5 -curcuminoid and structure–activity relationship of bis-thiol-adducts thereof", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 14, no. 45, 1 January 2016 (2016-01-01), pages 10683 - 10687, XP055965288, ISSN: 1477-0520, DOI: 10.1039/C6OB01771A
CAGNONI ALEJANDRO J., VARELA OSCAR, GOUIN SÉBASTIEN G., KOVENSKY JOSÉ, UHRIG MARÍA LAURA: "Synthesis of Multivalent Glycoclusters from 1-Thio-β-D-galactose and Their Inhibitory Activity against the β-Galactosidase from E. coli", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 76, no. 9, 6 May 2011 (2011-05-06), pages 3064 - 3077, XP055965286, ISSN: 0022-3263, DOI: 10.1021/jo102421e
Attorney, Agent or Firm:
YAMAMOTO, Noriaki (JP)
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