Title:
NOVEL COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/017557
Kind Code:
A1
Abstract:
Provided are: a compound suitable for imaging an intracerebral TRPV1 receptor; and a use thereof. A compound or a salt thereof represented by formula (I) is used. [In formula (1), R1 is a hydrogen or a random organic group; R2 is an organic group having 2 or more carbon atoms when R1 is a hydrogen, and a random organic group when R1 is not a hydrogen; and R1 and/or R2 has/have a radioactive isotope].
Inventors:
DOI HISASHI (JP)
WATANABE YASUYOSHI (JP)
TATEISHI UKIHIDE (JP)
KANOU DAISUKE (JP)
WATANABE YASUYOSHI (JP)
TATEISHI UKIHIDE (JP)
KANOU DAISUKE (JP)
Application Number:
PCT/JP2019/028110
Publication Date:
January 23, 2020
Filing Date:
July 17, 2019
Export Citation:
Assignee:
RIKEN (JP)
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
NAT CANCER CT (JP)
UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP)
NAT CANCER CT (JP)
International Classes:
C07C233/29; A61K51/04; A61P1/04; A61P11/00; A61P19/02; A61P25/00; A61P35/00; C07B59/00
Other References:
VAN VEGHEL, DAISY ET AL.: "Synthesis and biological evaluation of [11C] SB366791: A new PET-radio ligand for in vivo imaging of the TRPV1 receptor", NUCLEAR MEDICINE AND BIOLOGY, vol. 40, no. 1, 2013, pages 141 - 147, XP055676470
VAN VEGHEL, DAISY ET AL.: "New Transient Receptor Potential Vanilloid Subfamily Member 1 Positron Emission Tomography Radio ligands: Synthesis, Radio labeling, and Preclinical Evaluation", ACS CHEMICAL NEUROSCIENCE, vol. 4, no. 4, 2013, pages 624 - 634, XP055287079
BONACORSI, SAMUEL J., JR. ET AL.: "Synthesis of multi- labeled [14C] aripiprazole", JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, vol. 49, no. 1, 2006, pages 1 - 9
VAN VEGHEL, DAISY ET AL.: "New Transient Receptor Potential Vanilloid Subfamily Member 1 Positron Emission Tomography Radio ligands: Synthesis, Radio labeling, and Preclinical Evaluation", ACS CHEMICAL NEUROSCIENCE, vol. 4, no. 4, 2013, pages 624 - 634, XP055287079
BONACORSI, SAMUEL J., JR. ET AL.: "Synthesis of multi- labeled [14C] aripiprazole", JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, vol. 49, no. 1, 2006, pages 1 - 9
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
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