Title:
NOVEL CORONAVIRUS DETECTION TEST STRIP, AND PREPARATION METHOD AND USE METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/094932
Kind Code:
A1
Abstract:
A novel coronavirus detection test strip, and a preparation method and a use method therefor. The test strip comprises a lining plate (1), and a sample pad (2), a gold labeling pad (3), a detection pad (4) and a water absorption plate (5), which are sequentially arranged on the lining plate (1) from one end to the other end. A nitrocellulose membrane is arranged on the surface of the detection pad (4), and a detection T line and a quality control C line are disposed on the nitrocellulose membrane, wherein the detection T line is coated with a sialic acid ligand immobilization substance, which comprises a sialic acid ligand molecule with high affinity; and the quality control C line is coated with a control substance, which is SARS-CoV-2 S protein. A colloidal gold label is sprayed on the gold labeling pad (3), and the colloidal gold label is a gold nanoparticle having a sialic acid ligand molecule with moderate affinity immobilized on the surface. The test strip can be used to quickly and conveniently determine whether a sample contains SARS-CoV-2 particles, thereby quickly determining whether a subject is contagious.
Inventors:
LI WEI (CN)
WANG HUAIYU (CN)
WANG HUAIYU (CN)
Application Number:
PCT/CN2020/127148
Publication Date:
May 12, 2022
Filing Date:
November 06, 2020
Export Citation:
Assignee:
SHENZHEN INST ADV TECH (CN)
International Classes:
G01N33/543; C07H15/00; G01N33/569
Domestic Patent References:
| WO2020196296A1 | 2020-10-01 |
Foreign References:
| CN111443199A | 2020-07-24 | |||
| CN111686253A | 2020-09-22 | |||
| CN105658657A | 2016-06-08 | |||
| CN109021094A | 2018-12-18 | |||
| CN103551562A | 2014-02-05 | |||
| CN109553643A | 2019-04-02 | |||
| US10823746B1 | 2020-11-03 |
Other References:
BAKER ALEXANDER N., RICHARDS SARAH-JANE, GUY COLLETTE S., CONGDON THOMAS R., HASAN MUHAMMAD, ZWETSLOOT ALEXANDER J., GALLO ANGELO,: "The SARS-COV-2 Spike Protein Binds Sialic Acids and Enables Rapid Detection in a Lateral Flow Point of Care Diagnostic Device", ACS CENTRAL SCIENCE, vol. 6, no. 11, 25 November 2020 (2020-11-25), pages 2046 - 2052, XP055831478, ISSN: 2374-7943, DOI: 10.1021/acscentsci.0c00855
Attorney, Agent or Firm:
BEIJING CHENGHUI LAW FIRM (CN)
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