Title:
NOVEL CYSTEINE COMPOUND AND SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2013/141264
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel compound with Eg5 inhibiting activity that is useful as an antitumoral agent. The present invention pertains to a compound expressed by the general formula (I) (in formula (I), A represents Ch2, a sulfur atom, or an oxygen atom; and R represents a halogen atom, a C1-C6 alkyl group, a C1-C6 alkoxy group, or a trifluoromethyl group) or a salt thereof.
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Inventors:
ASAI AKIRA (JP)
OGO NAOHISA (JP)
SAWADA JUNICHI (JP)
HASHIMOTO AKIHIRO (JP)
OGO NAOHISA (JP)
SAWADA JUNICHI (JP)
HASHIMOTO AKIHIRO (JP)
Application Number:
PCT/JP2013/057903
Publication Date:
September 26, 2013
Filing Date:
March 19, 2013
Export Citation:
Assignee:
GEN INC ASS PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION (JP)
TAIHO PHARMACEUTICAL CO LTD (JP)
TAIHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07C323/61; A61K31/198; A61K31/38; A61P35/00; A61P43/00; C07D337/12
Domestic Patent References:
| WO1999041227A1 | 1999-08-19 |
Other References:
"Structure.Activity Relationship of S-Trityl-L- Cysteine Analogues as Inhibitors of the HumanMitotic Kinesin Eg5", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 5, 2008, pages 1115 - 1125
"Structure-Activity Relationship and Multidrug Resistance Study of New S-trityl-L-Cysteine Derivatives As Inhibitors of Eg5", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, no. 6, 2011, pages 1576 - 1586
"Synthesis and biological evaluation of L- cysteine derivativesas mitotic kinesin Eg5 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, 2007, pages 3921 - 3924
"Structure-Activity Relationship and Multidrug Resistance Study of New S-trityl-L-Cysteine Derivatives As Inhibitors of Eg5", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, no. 6, 2011, pages 1576 - 1586
"Synthesis and biological evaluation of L- cysteine derivativesas mitotic kinesin Eg5 inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, 2007, pages 3921 - 3924
Attorney, Agent or Firm:
HAMADA Yuriko et al. (JP)
Yuriko Hamada (JP)
Yuriko Hamada (JP)
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