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Title:
NOVEL ENT-KAURENE DITERPENE COMPOUND AND ITS DERIVATIVES, THEIR PREPARATION AND THEIR USE
Document Type and Number:
WIPO Patent Application WO/2007/082475
Kind Code:
A1
Abstract:
Novel ent-kaurene diterpene compound and its derivatives, their preparation methods and their use. ent-Kaurene diterpene in the present invention could be used as desired intermediates for preparing asymmetric organic compounds and medicaments, and could be used as antitumor agent, anti-inflammatory agent and immune agent etc. . The said ent-kaurene diterpene compound could be condensed with hydroxyl compounds to obtain various acetal derivatives, could be reacted with amine compounds to obtain various amino derivatives, and could be reacted with acyl halide or acid anhydride to obtain various acyl derivatives.

Inventors:
LIU HONGMIN (CN)
ZHU WENCHEN (CN)
ZHU CHENGGONG (CN)
WANG QINGDUAN (CN)
KE YU (CN)
LIU ZHENZHONG (CN)
YAN XUEBIN (CN)
ZHANG JIANYE (CN)
QU HONGLI (CN)
Application Number:
PCT/CN2007/000187
Publication Date:
July 26, 2007
Filing Date:
January 18, 2007
Export Citation:
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Assignee:
FUREN PHARMACEUTICAL GROUP CO (CN)
UNIV ZHENGZHOU (CN)
LIU HONGMIN (CN)
ZHU WENCHEN (CN)
ZHU CHENGGONG (CN)
WANG QINGDUAN (CN)
KE YU (CN)
LIU ZHENZHONG (CN)
YAN XUEBIN (CN)
ZHANG JIANYE (CN)
QU HONGLI (CN)
International Classes:
C07D311/94; A61K31/352; A61K31/7048; A61P29/00; A61P35/00; A61P37/02; C07H17/04
Foreign References:
US6894073B22005-05-17
CN1255502A2000-06-07
Other References:
NOMOTO K. ET AL.: "Rastronols A, B, C, D, E, F, G and H; a group of multioxygenated diterpene bitter principles of the ent-kaurane series from Englerastrum scandens Alston", HELVETICA CHIMICA ACTA, vol. 59, no. 3, 1976, pages 772 - 802, XP003015962
Attorney, Agent or Firm:
CN-KNOWHOW INTELLECTUAL PROPERTY AGENT LIMITED (Building 3 Jinqiuzhichun Garden No. 6, Zhichun Rd, Haidian District Beijing 8, CN)
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