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Patent Searching and Data


Title:
NOVEL EPOTHILONE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/185717
Kind Code:
A1
Abstract:
The present invention relates to a novel epothilone derivative having improved water solubility by glucosylation of epothilone, to a method for preparing an epothilone derivative, to a pharmaceutical composition containing the epothilone derivative as an active ingredient for cancer treatment, to a method for treating cancer using the pharmaceutical composition, and to a use of the epothilone derivative used in the preparation of the pharmaceutical composition for cancer treatment. The epothilone derivative of the present invention has improved water solubility when compared with the conventional epothilone without the deterioration in anticancer activity, and thus can be widely used in the formulation of epothilone.

Inventors:
KIM WON GON (KR)
PARK JI YEONG (KR)
KIM JOONG SU (KR)
KIM HYUN JU (KR)
Application Number:
PCT/KR2014/004346
Publication Date:
November 20, 2014
Filing Date:
May 15, 2014
Export Citation:
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Assignee:
KOREA RES INST OF BIOSCIENCE (KR)
International Classes:
C07H17/08; A61K31/7048; C07D417/14; C07D493/04
Foreign References:
US20100249050A12010-09-30
EP1881000A12008-01-23
Other References:
PANDEY, R. P. ET AL.: "Enzymatic synthesis of novel phloretin glucosides", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 79, no. 11, 29 March 2013 (2013-03-29), pages 3516 - 3521
WNAG, J. ET AL.: "Five new epothilone metabolites from Sorangium cellulosum strain So0157-2", THE JOURNAL OF ANTIBIOTICS, vol. 62, no. 9, 30 September 2009 (2009-09-30), pages 483 - 487
ZHAO, L. ET AL.: "Glycosylation and production characteristics of epothilones in alkali-tolerant Sorangium cellulosum strain So01 57-2", THE JOURNAL OF MICROBIOLOGY, vol. 48, no. 4, 31 August 2010 (2010-08-31), pages 438 - 444
PARAJULI, P ET AL.: "Enzymatic synthesis of epothilone A glycosides", AMS EXPRESS, vol. 4, no. 31, 20 March 2014 (2014-03-20), pages 1 - 10
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
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