NOVEL FK506 DERIVATIVE AND COMPOSITION COMPRISING SAME FOR PROMOTING HAIR GROWTH

Title:

NOVEL FK506 DERIVATIVE AND COMPOSITION COMPRISING SAME FOR PROMOTING HAIR GROWTH

Document Type and Number:

WIPO Patent Application WO/2022/139524

Kind Code:

A1

Abstract:

The present invention relates to preparation of the novel compound 9-deoxo-36,37-dihydro-prolylFK506, 9-deoxo-31-O-dimethyl-36,37-dihydro-prolylFK506 (9-deoxo-31-O-demethyl-36,37-dihydro-prolylFK506), 9-deoxo-prolylFK520 (9-deoxo-prolylFK520), or 9-deoxo-31-O-dimethyl-prolylFK520 (9-deoxo-31-O-demethyl-prolylFK520), which can be used as a main ingredient in a composition for promoting hair growth, and a use thereof in promoting hair growth.

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Inventors:

YOON YEO-JOON (KR)
SONG MYOUNG-CHONG (KR)
YOO YOUNG JI (KR)

Application Number:

PCT/KR2021/019771

Publication Date:

June 30, 2022

Filing Date:

December 23, 2021

Export Citation:

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Assignee:

SEOUL NAT UNIV R&DB FOUNDATION (KR)

International Classes:

A61K31/407; A23L33/10; A61K8/49; A61P17/14; A61Q5/00; A61Q7/00

Foreign References:

KR20200072388A	2020-06-22
KR20200072389A	2020-06-22
US5210030A	1993-05-11
US5493019A	1996-02-20

Other References:

BEOM JI YOON, JUNG JIN A, LEE KYUNG-TAE, HWANGBO AREUM, SONG MYOUNG CHONG, LEE YEONSEON, LEE SOO JUNG, OH JI HOON, HA SANG-JUN, NA: "Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity", JOURNAL OF NATURAL PRODUCTS, AMERICAN CHEMICAL SOCIETY, US, vol. 82, no. 8, 23 August 2019 (2019-08-23), US , pages 2078 - 2086, XP055945427, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.9b00144

Attorney, Agent or Firm:

ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)

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