Title:
NOVEL FLAVANONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2011/013735
Kind Code:
A1
Abstract:
Disclosed is a novel antibacterial agent. Specifically disclosed is a novel antibacterial agent which can exert an effective action on various resistant bacteria such as VSSA, MRSA, VISA, VRE and VRSA. A novel flavanone derivative having a derivative of a 6-membered monosaccharide, in particular a glucose derivative or a galactose derivative, can exert an effective action on the aforesaid various bacteria. More specifically, a compound represented by formula (I) is disclosed.
In formula (I), X represents a 6-membered monosaccharide derivative; and Y is substituted by a hydroxyl group.
Inventors:
SASAKI KENJI (JP)
TSUCHIYA TOMOFUSA (JP)
ABUGAFAR MD LOKMAN HOSSION (JP)
OHTSUKA NAO (JP)
ZAMAMI YOSHITO (JP)
KUROSAKI YUJI (JP)
TSUCHIYA TOMOFUSA (JP)
ABUGAFAR MD LOKMAN HOSSION (JP)
OHTSUKA NAO (JP)
ZAMAMI YOSHITO (JP)
KUROSAKI YUJI (JP)
Application Number:
PCT/JP2010/062759
Publication Date:
February 03, 2011
Filing Date:
July 29, 2010
Export Citation:
Assignee:
UNIV OKAYAMA NAT UNIV CORP (JP)
SASAKI KENJI (JP)
TSUCHIYA TOMOFUSA (JP)
ABUGAFAR MD LOKMAN HOSSION (JP)
OHTSUKA NAO (JP)
ZAMAMI YOSHITO (JP)
KUROSAKI YUJI (JP)
SASAKI KENJI (JP)
TSUCHIYA TOMOFUSA (JP)
ABUGAFAR MD LOKMAN HOSSION (JP)
OHTSUKA NAO (JP)
ZAMAMI YOSHITO (JP)
KUROSAKI YUJI (JP)
International Classes:
C07H17/07; A61K31/7048; A61P31/04
Domestic Patent References:
| WO2007075145A1 | 2007-07-05 |
Foreign References:
| JP2004115453A | 2004-04-15 | |||
| JP2009178718A | 2009-08-13 |
Other References:
HAZNI HAZRINA ET AL.: "Phytochemical constituents from Cassia alata with inhibition against methicillin-resistant Staphylo-coccus aureus (MRSA)", PLANTA MEDICA, vol. 74, no. 15, 2008, pages 1802 - 1805, XP008151473
LIU HONGMEI ET AL.: "Acylated flavonol glycosides from leaves of Stenochlaena palustris", JOURNAL OF NATURAL PRODUCTS, vol. 62, no. 1, 1999, pages 70 - 75, XP008151474
NISHIMURA TADAHIRO ET AL.: "Flavonoids that mimic human ligands from the whole plants of Euphorbia lunulata Chemical & Pharmaceutical Bulletin, 2005, 53(3), pp.305-308", FLAVONOIDS THAT MIMIC HUMAN LIGANDS FROM THE WHOLE PLANTS OF EUPHORBIA LUNULATA CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 53, no. 3, 2005, pages 305 - 308, XP008151475
See also references of EP 2460810A4
BIOL. PHARM. BULL., vol. 31, no. 9, 2008, pages 1794 - 1797
J. ETHNOPHARMACOLOGY, vol. 50, 1996, pages 27 - 34
LIU HONGMEI ET AL.: "Acylated flavonol glycosides from leaves of Stenochlaena palustris", JOURNAL OF NATURAL PRODUCTS, vol. 62, no. 1, 1999, pages 70 - 75, XP008151474
NISHIMURA TADAHIRO ET AL.: "Flavonoids that mimic human ligands from the whole plants of Euphorbia lunulata Chemical & Pharmaceutical Bulletin, 2005, 53(3), pp.305-308", FLAVONOIDS THAT MIMIC HUMAN LIGANDS FROM THE WHOLE PLANTS OF EUPHORBIA LUNULATA CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 53, no. 3, 2005, pages 305 - 308, XP008151475
See also references of EP 2460810A4
BIOL. PHARM. BULL., vol. 31, no. 9, 2008, pages 1794 - 1797
J. ETHNOPHARMACOLOGY, vol. 50, 1996, pages 27 - 34
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
Takashi Shoji (JP)
Takashi Shoji (JP)
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