Title:
NOVEL GENE PARTICIPATING IN EPIDERMAL DIFFERENTIATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2005/083075
Kind Code:
A1
Abstract:
A high through-put in situ hybridization system process has been applied to an epidermis of mouse sole in order to identify a novel gene participating in epidermal differentiation. As a result, about 100 types of unique mRNA expression patterns in the epidermis have been detected. Two novel secreted proteins, dermokine-&agr and -β, expressed in the epidermal layer resulting from differentiation of a superstratum of basal layer have been successfully identified therefrom. Further, it has been found that the genes coding for these proteins construct a novel gene complex (SSC).
Inventors:
MATSUI TAKESHI (JP)
KISUMI FUMIE (JP)
KINOSHITA YOKO (JP)
KISUMI FUMIE (JP)
KINOSHITA YOKO (JP)
Application Number:
PCT/JP2005/003458
Publication Date:
September 09, 2005
Filing Date:
March 02, 2005
Export Citation:
Assignee:
EISAI CO LTD (JP)
MATSUI TAKESHI (JP)
KISUMI FUMIE (JP)
KINOSHITA YOKO (JP)
MATSUI TAKESHI (JP)
KISUMI FUMIE (JP)
KINOSHITA YOKO (JP)
International Classes:
A61K31/7088; A61K31/7105; A61K39/395; A61K48/00; A61P17/00; A61P17/06; A61P17/16; A61P35/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/02; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/68; A61K9/00; A61K38/00; (IPC1-7): C12N15/09; A61K31/7088; A61K31/7105; A61K38/00; A61K39/395; A61K48/00; A61P17/00; A61P17/06; A61P17/16; A61P35/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/68
Domestic Patent References:
| WO2002068628A1 | 2002-09-06 | |||
| WO2002008288A2 | 2002-01-31 | |||
| WO2001021658A1 | 2001-03-29 |
Other References:
PARK G.T. ET AL: "Suprabasin, a Novel Epidermal Differentiation Marker and Potential Cornified Envelope Precursor", J BIOL CHEM, vol. 277, no. 47, November 2002 (2002-11-01), pages 45195 - 45202, XP002988269
OOMIZU S. ET AL.: "Kdap, a novel gene associated with the stratification of the epithelium.", GENE, vol. 256, 2000, pages 19 - 27, XP004238387
KOMIYA T. ET AL.: "A Larg-Scale in Situ Hybridization System Using an Equalized cDNA Library.", ANAL. BIOCHEM., vol. 254, 1997, pages 23 - 30, XP002988270
MOFFATT P. ET AL.: "Identification of a conserved cluster of skin-specific genes encoding secreted proteins.", GENE., vol. 334, 2004, pages 123 - 131, XP004522003
MATSUI T. ET AL.: "Indentification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1.", GENOMICS., vol. 84, 2004, pages 384 - 397, XP004518070
See also references of EP 1739171A4
OOMIZU S. ET AL.: "Kdap, a novel gene associated with the stratification of the epithelium.", GENE, vol. 256, 2000, pages 19 - 27, XP004238387
KOMIYA T. ET AL.: "A Larg-Scale in Situ Hybridization System Using an Equalized cDNA Library.", ANAL. BIOCHEM., vol. 254, 1997, pages 23 - 30, XP002988270
MOFFATT P. ET AL.: "Identification of a conserved cluster of skin-specific genes encoding secreted proteins.", GENE., vol. 334, 2004, pages 123 - 131, XP004522003
MATSUI T. ET AL.: "Indentification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1.", GENOMICS., vol. 84, 2004, pages 384 - 397, XP004518070
See also references of EP 1739171A4
Attorney, Agent or Firm:
Shimizu, Hatsushi (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki 47, JP)
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