Title:
NOVEL GLYCOSIDE COMPOUND AND PRODUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2018/070543
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for producing a phosphoramidite suitable for nucleic acid production (synthesis) with high efficiency and high purity. A phosphoramidite which allows for efficient nucleic acid synthesis can be obtained using a coupling reaction between a glycoside compound and an ether represented by chemical formula (105), an enantiomer, tautomer, or stereoisomer thereof, or a salt thereof (in the formula, n represents a positive integer, and R and R', which are the same or different, each represent a hydrogen atom or a protecting group for a hydroxy group.)
Inventors:
OHGI TADAAKI (JP)
AOKI ERIKO (JP)
KINOSHITA TAKASHI (JP)
ITOH AKIHIRO (JP)
EMURA CHISATO (JP)
AOKI ERIKO (JP)
KINOSHITA TAKASHI (JP)
ITOH AKIHIRO (JP)
EMURA CHISATO (JP)
Application Number:
PCT/JP2017/037279
Publication Date:
April 19, 2018
Filing Date:
October 13, 2017
Export Citation:
Assignee:
BONAC CORP (JP)
International Classes:
C07H19/067; C07C319/14; C07C319/20; C07C323/12; C07H19/167; C07H21/02; C07H23/00
Domestic Patent References:
| WO2008090829A1 | 2008-07-31 | |||
| WO2013027843A1 | 2013-02-28 | |||
| WO2013027843A1 | 2013-02-28 | |||
| WO2008090829A1 | 2008-07-31 |
Foreign References:
| JPH10500938A | 1998-01-27 | |||
| JP2003508062A | 2003-03-04 | |||
| JP2004505059A | 2004-02-19 | |||
| JP2008513593A | 2008-05-01 | |||
| JP2010517998A | 2010-05-27 | |||
| JP2016202663A | 2016-12-08 | |||
| JP2017053633A | 2017-03-16 |
Other References:
BOERNER, ARMIN. ET AL.: "Synthesis and catalytic properties of an acyclic analog of hydroxy norphos", TETRAHEDRON, vol. 50, no. 35, 1994, pages 10419 - 10430, XP055476105
DATABASE REGISTRY 4 December 2015 (2015-12-04), ANONYMOUS, XP055601277, retrieved from STN Database accession no. 1822852-78-7
RAVINDER, K. ET AL.: "Isolation and synthesis of a novel beta -carboline guanidine derivative tiruchanduramine from the Indian ascidian Synoicum macroglossum", TETRAHEDRON LETTERS, vol. 46, no. 33, 2005, pages 5475 - 5478, XP027862615
MORRISON BOYD ORGANIC CHEMISTRY, vol. 1, no. 5, 1991, pages 228, XP9515718
CENRY, MIRKO: "Formation of sulfur compounds in the hydrodenit rogenation of piperidine, pyridine, 1-pentylamine and 1-pent-4-enylamine on a nickel-tungsten catalyst in the presence of hydrogen sulfide", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 47, no. 3, 1982, pages 928 - 935, XP055476143
DANISHEFSKY, SAMUEL J. ET AL.: "Fully synthetic stereoselective routes to the differentially protected subunits of the tunicamycins", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 111, no. 15, 1 July 1989 (1989-07-01), pages 5810 - 5818, XP055476145, Retrieved from the Internet
ORGANIC SYNTHESES, vol. 9, 1998, pages 450
ORGANIC SYNTHESES, vol. 72, 1995, pages 16
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 32, 2015, pages 7009 - 7019
CURRENT PROTOCOLS IN NUCLEIC ACID CHEMISTRY, 2009
See also references of EP 3527578A4
DATABASE REGISTRY 4 December 2015 (2015-12-04), ANONYMOUS, XP055601277, retrieved from STN Database accession no. 1822852-78-7
RAVINDER, K. ET AL.: "Isolation and synthesis of a novel beta -carboline guanidine derivative tiruchanduramine from the Indian ascidian Synoicum macroglossum", TETRAHEDRON LETTERS, vol. 46, no. 33, 2005, pages 5475 - 5478, XP027862615
MORRISON BOYD ORGANIC CHEMISTRY, vol. 1, no. 5, 1991, pages 228, XP9515718
CENRY, MIRKO: "Formation of sulfur compounds in the hydrodenit rogenation of piperidine, pyridine, 1-pentylamine and 1-pent-4-enylamine on a nickel-tungsten catalyst in the presence of hydrogen sulfide", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 47, no. 3, 1982, pages 928 - 935, XP055476143
DANISHEFSKY, SAMUEL J. ET AL.: "Fully synthetic stereoselective routes to the differentially protected subunits of the tunicamycins", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 111, no. 15, 1 July 1989 (1989-07-01), pages 5810 - 5818, XP055476145, Retrieved from the Internet
ORGANIC SYNTHESES, vol. 9, 1998, pages 450
ORGANIC SYNTHESES, vol. 72, 1995, pages 16
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 32, 2015, pages 7009 - 7019
CURRENT PROTOCOLS IN NUCLEIC ACID CHEMISTRY, 2009
See also references of EP 3527578A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
Download PDF: