NOVEL GRANULE FORMULATION CONTAINING SILDENAFIL OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS AN ACTIVE INGREDIENT

WIPO Patent Application WO/2013/019056

A1

Disclosed is a rapidly dissolving granule formulation that is rapidly dissolved in the oral cavity. The granule formulation is rapidly dissolved in the oral cavity within 20 seconds after oral administration without leaving a feeling of foreign matter and a residual feeling. The granule formulation is produced by mixing an active ingredient with a rapidly dissolving carrier and granulating the mixture. The rapidly dissolving carrier meets the requirements: an instantaneous solubility of at least 30 mg/ml; a solubility after 5 minutes of at least 50 mg/ml; and the instantaneous solubility being 90% or less of a maximum solubility. The granule formulation can accomplish the desired effects irrespective of the kind of active ingredient. Therefore, the granule formulation is applicable to various active ingredients. In addition, the granule formulation can be produced in a relatively simple manner. This allows for an economical and efficient production process.

LEE JONG HOON (KR)
SHIM SANG BO (KR)
KIM SANG WOOK (KR)
YI HONG GI (KR)

PCT/KR2012/006086

February 07, 2013

July 31, 2012

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SAM A PHARM CO LTD (KR)
LEE JONG HOON (KR)
SHIM SANG BO (KR)
KIM SANG WOOK (KR)
YI HONG GI (KR)

A61K9/22; A61K9/16; A61K9/20; A61K31/519

WO2002062315A1

2002-08-15

KR20030076051A	2003-09-26
KR20010036527A	2001-05-07
KR20070100023A	2007-10-10
US20070202168A1	2007-08-30
US20090087485A1	2009-04-02

PARK, Jong Hyeok (1598-3 Seocho-dong Seocho-gu, Seoul 137-729, KR)

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