Title:
NOVEL HUMAN EPIDERMAL GROWTH FACTOR-TF FUSION PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/091304
Kind Code:
A1
Abstract:
The present invention relates to a novel human epidermal growth factor (hEGF)-trigger factor (TF) fusion protein and a use thereof. More particularly, the human epidermal growth factor (hEGF)-trigger factor (TF) fusion protein of the present invention has fused therein: a signal peptide of a Bacillus subtilis-derived xylanase; a human epidermal growth factor (hEGF); and an Escherichia coli-derived trigger factor (TF). Therefore, the present invention not only enhances the water solubility and expression rate of a target protein, but also notably enhances useful effects such as the effects of increasing skin cell growth and healing a wound, and thus may be widely used in various industries as an active ingredient for a functional cosmetic composition and a pharmaceutical composition.
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Inventors:
OH CHUL HONG (KR)
KANG YOON HYEOK (KR)
JO EUN YOUNG (KR)
KANG DO HYUNG (KR)
LEE YOUNG DEUK (KR)
JANG DUCK HEE (KR)
GANG YE HUI (KR)
EOM TAE YANG (KR)
HETTIARACHCHI SACHITHRA AMARIN (KR)
KANG YOON HYEOK (KR)
JO EUN YOUNG (KR)
KANG DO HYUNG (KR)
LEE YOUNG DEUK (KR)
JANG DUCK HEE (KR)
GANG YE HUI (KR)
EOM TAE YANG (KR)
HETTIARACHCHI SACHITHRA AMARIN (KR)
Application Number:
PCT/KR2020/015508
Publication Date:
May 14, 2021
Filing Date:
November 06, 2020
Export Citation:
Assignee:
KOREA INSTITUTE OF OCEAN SCIENCE ＆ TECH (KR)
International Classes:
C07K14/485; A61K8/64; A61K38/18; A61P17/00; A61Q19/00; C07K14/245
Foreign References:
| KR20100042305A | 2010-04-26 | |||
| KR20150056022A | 2015-05-22 |
Other References:
Internet Web Page. OH, Cheolhong et al. Production of functional proteins by using secretory signal peptide of marine bacteria origin. The 12th KSMB Annual Meeting and Symposium. 2016, p. 207. https://sciwatch.kiost.ac.kr/handle/2020.kiost/24286. See entire document. Y 6-10,15-17 A 1-5,11-14
DATABASE Protein GenPept; ANONYMOUS: "XynA, partial [Bacillus subtilis]", XP055812625, retrieved from NCBI
DATABASE Genbank Protein; ANONYMOUS: "epidermal growth factor, partial [Homo sapiens] - Protein - NCBI", XP055812629, retrieved from STN
DATABASE GenBank Protein; ANONYMOUS: "trigger factor [Escherichia coli]", XP055812631, retrieved from STN
KANG, Y. H. et al. Large quantities secretion to culture medium with epidermal growth factor and trigger factor fused protein in Escherichia coli. New Approaches and Concepts in Microbiology. 11 July 2019, p. 155. See entire document. ※ This document is a known document declaring exceptions to lack of novelty by the applicant. X 1-17
DATABASE Protein GenPept; ANONYMOUS: "XynA, partial [Bacillus subtilis]", XP055812625, retrieved from NCBI
DATABASE Genbank Protein; ANONYMOUS: "epidermal growth factor, partial [Homo sapiens] - Protein - NCBI", XP055812629, retrieved from STN
DATABASE GenBank Protein; ANONYMOUS: "trigger factor [Escherichia coli]", XP055812631, retrieved from STN
KANG, Y. H. et al. Large quantities secretion to culture medium with epidermal growth factor and trigger factor fused protein in Escherichia coli. New Approaches and Concepts in Microbiology. 11 July 2019, p. 155. See entire document. ※ This document is a known document declaring exceptions to lack of novelty by the applicant. X 1-17
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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