Title:
NOVEL INTEGRIN RECEPTOR ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO2001010847
Kind Code:
A3
Abstract:
The invention relates to novel compounds of formula (I) which bind to integrin receptors, wherein G and L have the following meaning: L is a structural element of formula IL, wherein T represents a COOH group or a radical that can be hydrolyzed to obtain COOH and U- represents (XL)a-(CRL<1>RL<2>)b-, -CRL<1>=CRL<2>-, ethylene or =CRL<1>-, wherein a is 0 or 1; b is 0, 1 or 2; XL represents CRL<3>RL<4>, NRL<5>, oxygen or sulfur and G is a structural element of formula IG, wherein the insertion of structural element G can occur in both orientations and XO represents nitrogen or CRG<1>. The invention also relates to the production of said compounds and to their use as medicaments.
Inventors:
KLING ANDREAS (DE)
GENESTE HERVE (DE)
LANGE UDO (DE)
LAUTERBACH ARNULF (DE)
GRAEF CLAUDIA ISABELLA (DE)
SUBKOWSKI THOMAS (DE)
HOLZENKAMP UTA (DE)
MACK HELMUT (DE)
SADOWSKI JENS (DE)
HORNBERGER WILFRIED (DE)
LAUX VOLKER (DE)
GENESTE HERVE (DE)
LANGE UDO (DE)
LAUTERBACH ARNULF (DE)
GRAEF CLAUDIA ISABELLA (DE)
SUBKOWSKI THOMAS (DE)
HOLZENKAMP UTA (DE)
MACK HELMUT (DE)
SADOWSKI JENS (DE)
HORNBERGER WILFRIED (DE)
LAUX VOLKER (DE)
Application Number:
PCT/EP2000/007440
Publication Date:
November 01, 2001
Filing Date:
August 01, 2000
Export Citation:
Assignee:
BASF AG (DE)
KLING ANDREAS (DE)
GENESTE HERVE (DE)
LANGE UDO (DE)
LAUTERBACH ARNULF (DE)
GRAEF CLAUDIA ISABELLA (DE)
SUBKOWSKI THOMAS (DE)
HOLZENKAMP UTA (DE)
MACK HELMUT (DE)
SADOWSKI JENS (DE)
HORNBERGER WILFRIED (DE)
LAUX VOLKER (DE)
KLING ANDREAS (DE)
GENESTE HERVE (DE)
LANGE UDO (DE)
LAUTERBACH ARNULF (DE)
GRAEF CLAUDIA ISABELLA (DE)
SUBKOWSKI THOMAS (DE)
HOLZENKAMP UTA (DE)
MACK HELMUT (DE)
SADOWSKI JENS (DE)
HORNBERGER WILFRIED (DE)
LAUX VOLKER (DE)
International Classes:
A61K31/4402; A61K31/55; A61K31/5513; A61P3/14; A61P5/18; A61P7/02; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P9/14; A61P13/12; A61P17/02; A61P17/06; A61P19/00; A61P19/08; A61P19/10; A61P29/00; A61P31/04; A61P31/12; A61P33/00; A61P35/00; A61P35/04; A61P43/00; C07D213/74; C07D223/20; C07D243/38; C07D401/06; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D409/12; C07D409/14; C07D417/06; C07D417/12; C07D417/14; C07D471/04; C07D495/04; C07D495/14; (IPC1-7): C07D401/12; A61K31/55; A61P43/00; C07D401/14; C07D213/73; C07D403/12; C07D491/04; C07D409/14; C07D223/20; C07D409/12; C07D417/12; C07D417/14; C07D495/04; C07D495/14
Domestic Patent References:
| WO1999015508A1 | 1999-04-01 | |||
| WO1997001540A1 | 1997-01-16 | |||
| WO1999031099A1 | 1999-06-24 |
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