Title:
NOVEL IODOBENZYL-BLEOMYCIN COMPOUND
Document Type and Number:
WIPO Patent Application WO/2011/096374
Kind Code:
A1
Abstract:
Provided is a novel iodobenzyl-bleomycin compound. Also provided are metal complexes that consist of the iodobenzyl-bleomycin compound and various metal atoms, such as an iodobenzyl-Co-bleomycin compound, that can accumulate on malignant tumors, and that have improved biological characteristics in terms of accumulability on malignant tumors compared to conventional compounds. Also provided are methods for synthesizing the iodobenzyl-bleomycin compound and the metal complexes of the iodobenzyl-bleomycin compound and various metal atoms. The novel iodobenzyl-bleomycin compound is synthesized by adding, to a terminal amino group of bleomycin, iodobenzyl iodide synthesized by using iodobenzyl alcohol and iodine as starting materials.
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Inventors:
ANDO ATSUSHI (JP)
ANDO ITSUKO (JP)
KURODA MASAHIRO (JP)
KANAZAWA SUSUMU (JP)
ANDO ITSUKO (JP)
KURODA MASAHIRO (JP)
KANAZAWA SUSUMU (JP)
Application Number:
PCT/JP2011/051974
Publication Date:
August 11, 2011
Filing Date:
February 01, 2011
Export Citation:
Assignee:
UNIV OKAYAMA NAT UNIV CORP (JP)
ANDO ATSUSHI (JP)
ANDO ITSUKO (JP)
KURODA MASAHIRO (JP)
KANAZAWA SUSUMU (JP)
ANDO ATSUSHI (JP)
ANDO ITSUKO (JP)
KURODA MASAHIRO (JP)
KANAZAWA SUSUMU (JP)
International Classes:
C07H15/26; A61K31/7064; A61K38/00; A61K51/00; A61P35/00; C07B59/00; G01N33/48; C07F15/06
Foreign References:
| US4758421A | 1988-07-19 | |||
| US5420228A | 1995-05-30 | |||
| US4933157A | 1990-06-12 | |||
| JP2006232843A | 2006-09-07 |
Other References:
C. M. VOS ET AL., INTERNATIONAL JOURNAL OF NUCLEAR MEDICINE AND BIOLOGY, vol. 9, no. 4, 1982, pages 237 - 243
LESLIE H. DERIEMER ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 22, no. 9, 1979, pages 1019 - 1023
C. M. VOS ET AL., EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol. 7, no. 2, 1982, pages 92 - 94
JUNICHI KAKINUMA ET AL., JAPANESE JOURNAL OF NUCLEAR MEDICINE, vol. 18, no. 6, 1981, pages 835 - 839
ALAN A. WILSON ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, no. 5, 1989, pages 1057 - 1062
S. M. N. EFANGE ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 22, no. 4, 1995, pages 437 - 444
SRIRAM SHANKAR ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, no. 12, 2005, pages 3889 - 3898
LESLIE H. DERIEMER ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 22, no. 9, 1979, pages 1019 - 1023
C. M. VOS ET AL., EUROPEAN JOURNAL OF NUCLEAR MEDICINE, vol. 7, no. 2, 1982, pages 92 - 94
JUNICHI KAKINUMA ET AL., JAPANESE JOURNAL OF NUCLEAR MEDICINE, vol. 18, no. 6, 1981, pages 835 - 839
ALAN A. WILSON ET AL., JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, no. 5, 1989, pages 1057 - 1062
S. M. N. EFANGE ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 22, no. 4, 1995, pages 437 - 444
SRIRAM SHANKAR ET AL., BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, no. 12, 2005, pages 3889 - 3898
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
Takashi Shoji (JP)
Takashi Shoji (JP)
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Claims: