NOVEL KCNQ POTASSIUM CHANNEL AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Title:

NOVEL KCNQ POTASSIUM CHANNEL AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2015/165352

Kind Code:

A1

Abstract:

The present invention provides a compound with a structure represented by general formula I or a pharmaceutically acceptable salt thereof, a preparation method for the compound or the salt, and a use of the compound or the pharmaceutically acceptable salt thereof in the preparation of medicaments for treating nervous system diseases, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke or neurodegenerative diseases. Compared with Retigabine, the compound of the present invention has better brain tissue absorption. Moreover, the compound provided by the present invention not only has greatly improved efficacy, but also has far fewer neurological side effects than Retigabine, and therefore has a wider safe window.

Inventors:

NAN FAJUN (CN)
LI MIN (CN)
GAO ZHAOBING (CN)
ZHANG YANGMING (CN)
HU HAINING (CN)
XU HAIYAN (CN)
LIU HUANAN (CN)
PI XIAOPING (CN)

Application Number:

PCT/CN2015/077216

Publication Date:

November 05, 2015

Filing Date:

April 22, 2015

Export Citation:

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Assignee:

SHANGHAI INST MATERIA MEDICA (CN)

International Classes:

A61K31/167; C07C271/28; A61K31/17; A61K31/27; A61K31/277; A61K31/341; A61P9/10; A61P25/00; A61P25/08; A61P25/28; C07C231/02; C07C233/62; C07C235/16; C07C235/74; C07C237/04; C07C237/22; C07C269/04; C07C269/06; C07C273/18; C07C275/64; C07C333/08; C07D307/24

Domestic Patent References:

WO2013060097A1	2013-05-02
WO2011012659A2	2011-02-03
WO2009083526A1	2009-07-09

Foreign References:

CN1761464A	2006-04-19
US5852053A	1998-12-22
US5384330A	1995-01-24
CN101056845A	2007-10-17

Other References: