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Title:
NOVEL MACROLIDE COMPOUND JK
Document Type and Number:
WIPO Patent Application WO/2001/064700
Kind Code:
A1
Abstract:
A compound JK represented by the following general formula (1) or a pharmacologically acceptable salt thereof. (In the formula, R is hydrogen or -CH¿3?). The compound has an excellent antibacterial effect on drug-resistant bacteria such as MRSA and is useful as an antibacterial agent.

Inventors:
TANAKA YASUSHI (JP)
KOMARI HISAYUKI (JP)
NEMOTO AKIRA (JP)
YAZAWA KATSUKIYO (JP)
MIKAMI YUZURU (JP)
Application Number:
PCT/JP2001/001363
Publication Date:
September 07, 2001
Filing Date:
February 23, 2001
Export Citation:
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Assignee:
HIGETA SHOYU KK (JP)
TANAKA YASUSHI (JP)
KOMARI HISAYUKI (JP)
NEMOTO AKIRA (JP)
YAZAWA KATSUKIYO (JP)
MIKAMI YUZURU (JP)
International Classes:
A61K31/7042; A61K31/7048; A61P31/04; C07H17/04; C07H17/08; C12N1/20; C12P19/60; C12R1/03; (IPC1-7): C07H17/04; C12P19/60; A61K31/7048; A61P31/04; C12N1/20
Foreign References:
Other References:
RAYMOND J. ANHTON ET AL.: "MM 46115, a new antibiotic from Actinomadura pelletieri/characteristics of the producing cultures, fermentation, isolation, physico-chemical and biological properties", J. ANTIBIOT., vol. 43, no. 11, 1990, pages 1387 - 1393, XP002939731
KONG LUK ET AL.: "Structural studies of MM46115, a novel tetronic acid containing macrolide with antiviral and antibacterial activity isolated from Actinomadura pelletieri", J. CHEM. SOC. PARKIN TRANS. 1, vol. 7, 1991, pages 1641 - 1644, XP002939732
ISAO MOMOSE ET AL.: "Decatromicins A and B, new antibiotics produced by Actinomadura sp.MK73-NF4. I. Taxonomy, isolation, physico-chemical properties and biological activities", J. ANTIBIOT., vol. 52, no. 9, 1999, pages 781 - 786, XP002939733
ISAO MOMOSE ET AL.: "Decatromicins A and B, new antibiotics produced by Actinomadura sp.MK73-NF4. II. Structure determination", J. ANTIBIOT., vol. 52, no. 9, 1999, pages 787 - 796, XP002939734
See also references of EP 1201677A4
Attorney, Agent or Firm:
Toda, Chikao (Toranomon Minato-ku Tokyo, JP)
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