Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
NOVEL NONSTEROIDAL ANTI-INFLAMMATORY SUBSTANCES, COMPOSITIONS AND METHODS FOR THEIR USE
Document Type and Number:
WIPO Patent Application WO2004005309
Kind Code:
A3
Abstract:
The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, D represents a nonsteroidal subunit (nonsteroidal moiety) derived from nonsteroid drug with anti-inflammatory, analgesic and/or antipyretic activity (NSAID) and L represents a linking group covalently linking M and D; (b) to their pharmacologically acceptable salts, prodrugs and solvates, (c) to processes and intermediates for their preparation, and (d) to their use in the treatment of inflammatory diseases and conditions in humans and animals.

Inventors:
MERCEP MLADEN (HR)
MESIC MILAN (HR)
TOMASKOVIC LINDA (HR)
MARKOVIC STRIBOR (HR)
Application Number:
PCT/HR2003/000035
Publication Date:
April 15, 2004
Filing Date:
July 07, 2003
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
PLIVA D D (HR)
MERCEP MLADEN (HR)
MESIC MILAN (HR)
TOMASKOVIC LINDA (HR)
MARKOVIC STRIBOR (HR)
International Classes:
C07H17/08; A61K31/7048; A61K31/7052; A61P1/04; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P11/08; A61P17/00; A61P17/06; A61P17/16; A61P19/02; A61P19/04; A61P19/06; A61P21/00; A61P27/02; A61P29/00; A61P31/04; A61P37/06; C07H17/00; (IPC1-7): C07H17/00; C07H17/08; A61K31/7048; A61P29/00
Domestic Patent References:
WO1998056801A11998-12-17
WO1999064040A11999-12-16
WO2002055531A12002-07-18
WO2003070254A12003-08-28
Foreign References:
EP0283055A21988-09-21
GB2327084A1999-01-13
EP0895999A11999-02-10
EP0984019A12000-03-08
US20010006962A12001-07-05
Other References:
COSTA A M ET AL: "Hybrids of macrolides and nucleobases or nucleosides", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 41, no. 18, April 2000 (2000-04-01), pages 3371 - 3375, XP004198041, ISSN: 0040-4039
Download PDF: