Title:
NOVEL NUCLEIC ACID MOLECULE
Document Type and Number:
WIPO Patent Application WO/2022/169339
Kind Code:
A1
Abstract:
The present invention relates to a nucleic acid molecule, including a nucleic acid encoding a signal peptide and a nucleic acid encoding an antigen, for prevention or treatment of viral infection or cancer. In addition, the present invention relates to a vaccine composition containing the nucleic acid molecule for prevention or treatment of viral infection or cancer. The nucleic acid molecule according to the present invention is superb in terms of intracellular protein expression rate and extracellular protein secretion. In addition, when administered in vivo, the nucleic acid molecule allows the subject to acquire the humoral immunity of inducing antigen-specific neutralizing antibodies and the cellular immunity of increasing an amount of immune cells directly involved in killing viruses and as such, can be advantageously utilized as a vaccine for prevention and treatment of virus infection or cancer.
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Inventors:
KIM KYUNGJIN (KR)
YANG JOO-SUNG (KR)
CHOI KANG HYUN (KR)
LEE YUN CHAE (KR)
YANG JOO-SUNG (KR)
CHOI KANG HYUN (KR)
LEE YUN CHAE (KR)
Application Number:
PCT/KR2022/001874
Publication Date:
August 11, 2022
Filing Date:
February 07, 2022
Export Citation:
Assignee:
ST PHARM CO LTD (KR)
International Classes:
C12N15/62; A61K39/215; A61K47/50; A61P31/14; A61P35/00; C07K14/005; C07K14/33; C07K16/00
Domestic Patent References:
| WO2020092880A1 | 2020-05-07 |
Foreign References:
| KR20190003471A | 2019-01-09 |
Other References:
TREVOR R. F. SMITH, AMI PATEL, STEPHANIE RAMOS, DUSTIN ELWOOD, XIZHOU ZHU, JIAN YAN, EBONY N. GARY, SUSANNE N. WALKER, KATHERINE S: "Immunogenicity of a DNA vaccine candidate for COVID-19", NATURE COMMUNICATIONS, vol. 11, no. 1, 2601, 1 December 2020 (2020-12-01), XP055767550, DOI: 10.1038/s41467-020-16505-0
ELSAYED, HASSAN, GHULAM NABI, WILLIAM J. MCKINSTRY, KEITH K. KHOO, JOHNSON MAK, ANDRES M. SALAZAR, MATTHIAS TENBUSCH, VLADIMIR TEM: "Intrastructural Help: Harnessing T Helper Cells Induced by Licensed Vaccines for Improvement of HIV Env Antibody Responses to Virus-Like Particle Vaccines", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 92, no. 14, e00141-18, 1 July 2018 (2018-07-01), US , XP055956935, ISSN: 0022-538X, DOI: 10.1128/JVI.00141-18
KUTZLER MICHELE A.; WEINER DAVID B.: "DNA vaccines: ready for prime time?", NATURE REVIEWS GENETICS, vol. 9, no. 10, 1 October 2008 (2008-10-01), Nature Publishing Group, GB, pages 776 - 788, XP037134884, ISSN: 1471-0056, DOI: 10.1038/nrg2432
ELSAYED, HASSAN, GHULAM NABI, WILLIAM J. MCKINSTRY, KEITH K. KHOO, JOHNSON MAK, ANDRES M. SALAZAR, MATTHIAS TENBUSCH, VLADIMIR TEM: "Intrastructural Help: Harnessing T Helper Cells Induced by Licensed Vaccines for Improvement of HIV Env Antibody Responses to Virus-Like Particle Vaccines", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 92, no. 14, e00141-18, 1 July 2018 (2018-07-01), US , XP055956935, ISSN: 0022-538X, DOI: 10.1128/JVI.00141-18
KUTZLER MICHELE A.; WEINER DAVID B.: "DNA vaccines: ready for prime time?", NATURE REVIEWS GENETICS, vol. 9, no. 10, 1 October 2008 (2008-10-01), Nature Publishing Group, GB, pages 776 - 788, XP037134884, ISSN: 1471-0056, DOI: 10.1038/nrg2432
Attorney, Agent or Firm:
IPSCENT (KR)
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