Title:
NOVEL OXIDIZED LAPPACONITINE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/182803
Kind Code:
A1
Abstract:
The present invention relates to a novel oxidized lappaconitine derivative and a pharmaceutically acceptable salt thereof, a preparation method therefor, and a medical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into preosteoblasts, and increases bone density when administered to an osteoporosis animal model, and induces osteogenesis, and thus can effectively used for preventing, alleviating, or treating bone-related diseases such as osteoporosis.
Inventors:
CHANG MUN SEOG (KR)
LEE TAE HEE (KR)
KIM HA YOUNG (KR)
MIN JUNG BIN (KR)
LEE TAE HEE (KR)
KIM HA YOUNG (KR)
MIN JUNG BIN (KR)
Application Number:
PCT/KR2021/002751
Publication Date:
September 16, 2021
Filing Date:
March 05, 2021
Export Citation:
Assignee:
QGENETICS CO LTD (KR)
International Classes:
C07D223/32; A23L33/10; A61K31/55; A61P19/00
Domestic Patent References:
| WO2017209653A1 | 2017-12-07 | |||
| WO2017209653A1 | 2017-12-07 |
Foreign References:
| US20180093966A1 | 2018-04-05 | |||
| CN107540680A | 2018-01-05 | |||
| CN1305811A | 2001-08-01 | |||
| CN107540680A | 2018-01-05 |
Other References:
TSYRLINA E. M.; GABBASOV T. M.; SPIRIKHIN L. V.; YUNUSOV M. S.: "Isoxazolidine Derivatives of Lappaconitine and Talatisamine", CHEMISTRY OF NATURAL COMPOUNDS, vol. 54, no. 3, 6 June 2018 (2018-06-06), pages 515 - 519, XP036523704, ISSN: 0009-3130, DOI: 10.1007/s10600-018-2393-0
XU ET AL., J ETHNOPHARMACOL, 2006
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S.M. BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1
GARG ET AL., ORTHOP SURG, 2017
BRUDERER M ET AL., EUR CELL MATER, 2014
SUN J ET AL., MOL MED REP, 2015
LEE ET AL., CELL, 2007
BHARADWAJ ET AL., OSTEOPOROSIS INTERNATIONAL., 2009
GREENBLATT ET AL., MB, ANNU REV CELL DEV BIOL., 2013
GREENBLATT ET AL., MB, ANNU REV CELL DEV BIOL, 2013
XU ET AL., J ETHNOPHARMACOL, 2006
TURABEKOVA ET AL., ENVIRON TOXICOL PHARMACOL, 2008
WANG ET AL., CHEM PHARM BULL., 2009
S.M. BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1
GARG ET AL., ORTHOP SURG, 2017
BRUDERER M ET AL., EUR CELL MATER, 2014
SUN J ET AL., MOL MED REP, 2015
LEE ET AL., CELL, 2007
BHARADWAJ ET AL., OSTEOPOROSIS INTERNATIONAL., 2009
GREENBLATT ET AL., MB, ANNU REV CELL DEV BIOL., 2013
GREENBLATT ET AL., MB, ANNU REV CELL DEV BIOL, 2013
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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