Title:
NOVEL P62 LIGAND COMPOUND, AND COMPOSITION CONTAINING SAME FOR PREVENTING, ALLEVIATING, OR TREATING PROTEIN ABNORMALITY DISORDERS
Document Type and Number:
WIPO Patent Application WO/2020/022783
Kind Code:
A1
Abstract:
The present invention pertains to: a novel p62 ligand compound or a stereoisomer, solvate, hydrate, or prodrug thereof; and a pharmaceutical or food composition containing same as an active ingredient for preventing or treating protein abnormality disorders. A p62 ligand compound according to the present invention can be useful as a pharmaceutical composition for preventing, alleviating, or treating various protein abnormality disorders by activating intracellular autophagy and selectively removing proteins, organelles, and coagulants in the body.
Inventors:
KWON YONG TAE (KR)
JI CHANG HOON (KR)
GANIPISETTI SRINIVASRAO (KR)
KIM HEE YEON (KR)
MUN SU RAN (KR)
JUNG CHAN HOON (KR)
JUNG EUI JUNG (KR)
SUNG KI WOON (KR)
JI CHANG HOON (KR)
GANIPISETTI SRINIVASRAO (KR)
KIM HEE YEON (KR)
MUN SU RAN (KR)
JUNG CHAN HOON (KR)
JUNG EUI JUNG (KR)
SUNG KI WOON (KR)
Application Number:
PCT/KR2019/009203
Publication Date:
January 30, 2020
Filing Date:
July 24, 2019
Export Citation:
Assignee:
PROTECH CO LTD (KR)
International Classes:
C07C235/34; A61K31/135; A61K31/165; A61K31/17; A61P3/10; A61P25/00; C07C275/24; C07C279/12
Foreign References:
| KR20170021525A | 2017-02-28 | |||
| US4167581A | 1979-09-11 | |||
| KR20170023045A | 2017-03-02 | |||
| US20160031799A1 | 2016-02-04 |
Other References:
BARLOW J J; MAIN B G; SNOW H M: "beta-Adrenoceptor stimulant properties of amidoalkylamino- substituted 1-aryl-2-ethanols and 1-(aryloxy)-2-propanols", JOURNAL OF MEDICINAL CHEMISTRY, vol. 24, no. 3, 1 January 1981 (1981-01-01), pages 315 - 322, XP002222784, ISSN: 0022-2623, DOI: 10.1021/jm00135a015
TASAKI, T. ET AL., MOL CELL BIOL, vol. 25, 2005, pages 7120 - 36
SRIRAM, S.M.KIM, B.Y.KWON, Y.T., NAT REV MOL CELL BIOL, vol. 12, 2011, pages 735 - 47
SRIRAM, S.M.KWON, Y.T., NAT STRUCT MOL BIOL, vol. 17, 2010, pages 1164 - 5
JI, C.H.KWON, Y.T., MOL CELLS, vol. 40, 2017, pages 441 - 449
CIECHANOVER, A.KWON, Y.T., EXP MOL MED, vol. 47, 2015, pages e147
DIKIC, I.ELAZAR, Z., NAT REV MOL CELL BIOL, vol. 19, 2018, pages 349 - 364
JUNG, C. H.RO, S. H.CAO, J.OTTO, N. M.KIM, D. H., FEBS LETT, vol. 584, 2010, pages 1287 - 95
CACCAMO, A.MAJUMDER, S.RICHARDSON, A.STRONG, R.ODDO, S., J BIOL CHEM, vol. 285, 2010, pages 13107 - 20
RODRIGUEZ-NAVARRO, J.A. ET AL., NEUROBIOL DIS, vol. 39, 2010, pages 423 - 38
WEBB, J.L.RAVIKUMAR, B.ATKINS, J.SKEPPER, J.N.RUBINSZTEIN, D.C., J BIOL CHEM, vol. 278, 2003, pages 25009 - 13
RAVIKUMAR, B.DUDEN, R.RUBINSZTEIN, D.C., HUM MOL GENET, vol. 11, 2002, pages 1107 - 17
See also references of EP 3828162A4
TASAKI, T. ET AL., MOL CELL BIOL, vol. 25, 2005, pages 7120 - 36
SRIRAM, S.M.KIM, B.Y.KWON, Y.T., NAT REV MOL CELL BIOL, vol. 12, 2011, pages 735 - 47
SRIRAM, S.M.KWON, Y.T., NAT STRUCT MOL BIOL, vol. 17, 2010, pages 1164 - 5
JI, C.H.KWON, Y.T., MOL CELLS, vol. 40, 2017, pages 441 - 449
CIECHANOVER, A.KWON, Y.T., EXP MOL MED, vol. 47, 2015, pages e147
DIKIC, I.ELAZAR, Z., NAT REV MOL CELL BIOL, vol. 19, 2018, pages 349 - 364
JUNG, C. H.RO, S. H.CAO, J.OTTO, N. M.KIM, D. H., FEBS LETT, vol. 584, 2010, pages 1287 - 95
CACCAMO, A.MAJUMDER, S.RICHARDSON, A.STRONG, R.ODDO, S., J BIOL CHEM, vol. 285, 2010, pages 13107 - 20
RODRIGUEZ-NAVARRO, J.A. ET AL., NEUROBIOL DIS, vol. 39, 2010, pages 423 - 38
WEBB, J.L.RAVIKUMAR, B.ATKINS, J.SKEPPER, J.N.RUBINSZTEIN, D.C., J BIOL CHEM, vol. 278, 2003, pages 25009 - 13
RAVIKUMAR, B.DUDEN, R.RUBINSZTEIN, D.C., HUM MOL GENET, vol. 11, 2002, pages 1107 - 17
See also references of EP 3828162A4
Attorney, Agent or Firm:
YOU ME PATENT AND LAW FIRM (KR)
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