NOVEL PENTOSE DERIVATIVES AS ANTI-HYPERGLYCEMIC DRUGS

Title:

NOVEL PENTOSE DERIVATIVES AS ANTI-HYPERGLYCEMIC DRUGS

Document Type and Number:

WIPO Patent Application WO2004034960

Kind Code:

A3

Abstract:

The present invention relates to pentose and pentose derivatives that are effective at increasing glucose transport in a non-insulin dependent manner, and to uses thereof for a) treating and/or preventing hyperglycemia; b) treating and/or preventing the complications of hyperglycemia; c) treating diabetes; d) increasing the rate of cellular glucose transport; e) increasing the rate of cellular glucose uptake; f) improving the ability of a subject to metabolize glucose; g) treating daily blood glucose fluctuations; h) reducing blood sugar levels; i) reducing the dosage of anti-diabetic medication needed for treatment of diabetes. The present invention further provides novel pentose derivatives having beneficial properties in terms of pharmacokinetics, to pharmaceutical compositions comprising these novel compounds and uses thereof.

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Inventors:

SASSON SHLOMO (IL)
CERASI EROL (IL)
GRUZMAN ARIE (IL)
KATZHENDLER JOSHUA (IL)

Application Number:

PCT/IL2003/000852

Publication Date:

September 23, 2004

Filing Date:

October 20, 2003

Export Citation:

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Assignee:

YISSUM RES DEV CO (IL)
HADASIT MED RES SERVICE (IL)
SASSON SHLOMO (IL)
CERASI EROL (IL)
GRUZMAN ARIE (IL)
KATZHENDLER JOSHUA (IL)

International Classes:

C07H9/04; C07H15/04; C07H15/14; (IPC1-7): C07H15/00; A61K31/70

Foreign References:

US5432163A	1995-07-11
US6329344B1	2001-12-11

Other References: