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Title:
NOVEL PHENYL GLYOXAL PROBES
Document Type and Number:
WIPO Patent Application WO/2013/184645
Kind Code:
A3
Abstract:
Novel phenyl-glyoxal based anti-citrulline probes and methods of synthesis are provided. Methods of use, such as, the development of methods for monitoring substrate citrullination over time; for identifying citrullinated proteins from cells are described.

Inventors:
THOMPSON PAUL R (US)
BICKER KEVIN L (US)
SUBRAMANIAN VENKATARAMAN (US)
Application Number:
PCT/US2013/044048
Publication Date:
October 30, 2014
Filing Date:
June 04, 2013
Export Citation:
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Assignee:
SCRIPPS RESEARCH INST (US)
International Classes:
C07C239/00; C07C237/00; C07K1/02; C07K2/00; C08G63/91; C12Q1/34; G01N33/53
Foreign References:
US20110165606A12011-07-07
Other References:
NGO, TT ET AL.: "p-Azidophenylglyoxal.", A HETEROBIFUNCTIONAL PHOTOACTIVABLE CROSS-LINKING REAGENT SELECTIVE FOR ARGINYL RESIDUES., vol. 256, no. 21, 10 November 1981 (1981-11-10), pages 11313 - 11318, XP055178244
KAR, A.: "Local Anaesthetics.", MEDICINAL CHEMISTRY, 2007, NEW DELHI, INDIA, pages 128 - 168, XP008175616
SURESHBABU, VV ET AL.: "Protection Reactions.", AMINO ACIDS, PEPTIDES AND PROTEINS IN ORGANIC CHEMISTRY: PROTECTION REACTIONS, MEDICINAL CHEMISTRY, COMBINATORIAL SYNTHESIS, vol. 4, 2011, WEINHEIM, GERMANY, pages 1 - 97, XP055178448
MATSUO, K ET AL., IDENTIFICATION OF NOVEL CITRULLINATED AUTOANTIGENS OF SYNOVIUM IN RHEUMATOI ARTHRITIS USING A PROTEOMIC APPROACH., vol. 8, no. 6, 2006, pages R175 - 1-13, XP021026931
LUO, Y ET AL., INHIBITORS AND INACTIVATORS OF PROTEIN ARGININE DEIMINASE 4: FUNCTIONAL AND STRUCTURAL CHARACTERIZATION., vol. 45, no. 39, 3 October 2006 (2006-10-03), pages 11727 - 11736, XP055126480
Attorney, Agent or Firm:
SLAVIN, Michael A. (P.A.2855 PGA Boulevar, Palm Beach Gardens FL, US)
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