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Title:
NOVEL PLK1 DEGRADATION INDUCING COMPOUND
Document Type and Number:
WIPO Patent Application WO/2023/018238
Kind Code:
A1
Abstract:
The present disclosure relates to a novel PLK1 degradation inducing compound, a method for preparing the same, and the use thereof. The compounds of the present disclosure exhibit an effect of inducing PLK1 degradation. Therefore, the compounds of the present disclosure may be effectively utilized for preventing or treating PLK1-related diseases.

Inventors:
RYU SOO HEE (KR)
MIN IM SUK (KR)
LEE HAN KYU (KR)
KIM SEONG HOON (KR)
RYU HYE GUK (KR)
KANG KEUM YOUNG (KR)
KIM SANG YOUN (KR)
CHUNG SO HYUN (KR)
LEE JUN KYU (KR)
LEE GIBBEUM (KR)
Application Number:
PCT/KR2022/011963
Publication Date:
February 16, 2023
Filing Date:
August 10, 2022
Export Citation:
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Assignee:
UPPTHERA INC (KR)
International Classes:
C07D487/04; A61K31/55; A61K31/551; A61K47/55; A61P25/00; A61P35/00
Domestic Patent References:
WO2021061894A12021-04-01
WO2009153197A12009-12-23
Foreign References:
CN109879877A2019-06-14
CN106543185A2017-03-29
US20160176916A12016-06-23
US20200325130A12020-10-15
CN106543185A2017-03-29
Other References:
GHEGHIANI ET AL., CELL REPORTS, 2017
BOLDEN ET AL., CELL REPORTS, 2014
MU ET AL., BBRC, 2019
MU ET AL., BBRC, vol. 521, no. 4, 2020, pages 833
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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