Title:
NOVEL PROCESS FOR PREPARATION OF 10-OXO-10, 11-DIHYDRO-5H-DIBENZ [b,f]AZEPINE-5-CARBOXAMIDE (OXCARBAZEPINE) VIA INTERMEDIATE, 10-METHOXY-5H-DIBENZ[b,f] AZEPINE-5-CARBONYLCHLORIDE
Document Type and Number:
WIPO Patent Application WO2005066133
Kind Code:
A3
Abstract:
Novel process for preparation of 10-oxo-10, 11-dihydro-SH-dibenz[b,f] azepine-5-carboxamide (oxcarbazepine) via intermediate 10-methoxy-5H-dibenz [b,f] azepine -5 carbonyl, chloride; comprising the steps: a) Preparation of an intermediate 10-methoxy-5H-dibenz [b,f] azepine -5 carbonyl, chloride from 10-methoxyiminostillbene using bis (trichloromethyl) carbonate (BTC) with organic base such as aliphatic or aromatic tertiary amines in organic solvent b) Conversion of the intermediate to 10-methoxy-5H-dlbenz[b,f] azepine -5- carboxamide using ammonia in organic solvent c) Formation of oxcarbazepine from step(b) using Lewis acid in an organic solvent at a temperature between 25°C - 80°C, preferably at 50°C to 70°C d) Isolation of oxcarbazepine.
Inventors:
PARENKY CHANDRASHEKAR (IN)
CHATURVEDI ROHIT (IN)
CHATURVEDI ROHIT (IN)
Application Number:
PCT/IN2004/000322
Publication Date:
October 06, 2005
Filing Date:
October 15, 2004
Export Citation:
Assignee:
AMOLI ORGANICS LTD (IN)
PARENKY CHANDRASHEKAR (IN)
CHATURVEDI ROHIT (IN)
PARENKY CHANDRASHEKAR (IN)
CHATURVEDI ROHIT (IN)
International Classes:
C07D223/22; (IPC1-7): C07D223/22
Foreign References:
| DE2011087A1 | 1970-09-24 | |||
| US5808058A | 1998-09-15 |
Other References:
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HAASZ, FERENC ET AL: "Improved process for producing 5-carbamoyl-10-oxo-10,11-dihydro-5H- dibenz[b,f]azepine", XP002334714, retrieved from STN Database accession no. 1994:164010
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