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Patent Searching and Data


Title:
NOVEL PYRAZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2012/141228
Kind Code:
A1
Abstract:
Provided is a novel therapeutic means for Alzheimer's disease. A compound represented by general formula (I) [wherein Ar1 represents a 2-methoxy-4-(2-pyridylmethoxy)phenyl group or the like; and Ar2 represents a 1H-indole-6-yl group or the like] or a salt thereof.

Inventors:
SUGIMOTO HACHIRO (JP)
OKUDA MITSUAKI (JP)
TAKAHASHI TAKASHI (JP)
HIJIKURO ICHIRO (JP)
SUZUKI HIDEAKI (JP)
NAKAYAMA SHINICHI (JP)
Application Number:
PCT/JP2012/059944
Publication Date:
October 18, 2012
Filing Date:
April 11, 2012
Export Citation:
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Assignee:
PHARMA EIGHT CO LTD (JP)
SUGIMOTO HACHIRO (JP)
OKUDA MITSUAKI (JP)
TAKAHASHI TAKASHI (JP)
HIJIKURO ICHIRO (JP)
SUZUKI HIDEAKI (JP)
NAKAYAMA SHINICHI (JP)
International Classes:
C07D401/14; A61K31/4155; A61K31/4439; A61K31/496; A61K31/498; A61K31/5377; A61K31/7004; A61P25/28; A61P43/00; C07D209/12; C07D401/12; C07D403/06; C07D405/12; C07D405/14; C07D409/12; C07D409/14; C07D417/12; C07D417/14; C07D471/04; C07H15/203
Domestic Patent References:
WO2005006945A22005-01-27
WO2010045395A22010-04-22
WO2003105751A22003-12-24
WO2008030072A12008-03-13
WO2008066151A12008-06-05
WO2009145219A12009-12-03
Foreign References:
JP2008513464A2008-05-01
JP2005534626A2005-11-17
JP2008129132A2008-06-05
JP2008137914A2008-06-19
JP2010168344A2010-08-05
Other References:
LI,Q. ET AL.: "Styryl-based compounds as potential in vivo imaging agents for beta-amyloid plaques", CHEMBIOCHEM, vol. 8, no. 14, 2007, pages 1679 - 1687, XP002643260
See also references of EP 2698368A4
FUSHENG YANG ET AL., J. BIOL. CHEM., vol. 280, no. 7, 18 February 2005 (2005-02-18), pages 5892 - 5901
RAJESHWAR NARLAWAR ET AL., CHEMMEDCHEM, vol. 3, 2008, pages 165 - 172
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
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Claims: