Title:
NOVEL QUINAZOLINE DERIVATIVE COMPOUND AS SOS1 INHIBITOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/139304
Kind Code:
A1
Abstract:
The present invention relates to a novel quinazoline derivative compound that serves as an SOS1 inhibitor, and a use thereof, and more specifically to: a novel quinazoline derivative compound having inhibitory activity against SOS1 binding to RAS family proteins and/or RAC1; a pharmacologically acceptable salt thereof; or a pharmaceutical composition containing the compound.
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Inventors:
CHOI JAE YUL (KR)
KIM WON JEOUNG (KR)
KIM JI SOOK (KR)
KIM MIN JEONG (KR)
PARK WON GI (KR)
AHN YOUNG GIL (KR)
BAE IN HWAN (KR)
KIM WON JEOUNG (KR)
KIM JI SOOK (KR)
KIM MIN JEONG (KR)
PARK WON GI (KR)
AHN YOUNG GIL (KR)
BAE IN HWAN (KR)
Application Number:
PCT/KR2021/019011
Publication Date:
June 30, 2022
Filing Date:
December 14, 2021
Export Citation:
Assignee:
HANMI PHARMACEUTICAL CO LTD (KR)
International Classes:
C07D239/94; A61K31/517; A61K31/5377; A61P35/00; C07D403/04; C07D405/12; C07D409/12
Domestic Patent References:
| WO2000051991A1 | 2000-09-08 | |||
| WO2018115380A1 | 2018-06-28 |
Foreign References:
| EP1229025A1 | 2002-08-07 | |||
| US6046206A | 2000-04-04 |
Other References:
TOBE, M. ISOBE, Y. TOMIZAWA, H. MATSUMOTO, M. OBARA, F. NAGASAKI, T. HAYASHI, H.: "Structure-activity relationships of quinazoline derivatives: dual-acting compounds with inhibitory activities toward both TNF-@a production and T Cell proliferation", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 11, no. 4, 26 February 2001 (2001-02-26), Amsterdam NL , pages 545 - 548, XP004230055, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(00)00718-6
TOBE MASANORI, ISOBE YOSHIAKI, TOMIZAWA HIDEYUKI, NAGASAKI TAKAHIRO, OBARA FUMIHIRO, HAYASHI HIDEYA: "Structure–Activity relationships of 6-fluoroquinazolines: dual-Acting compounds with inhibitory activities toward both TNF-α production and T cell proliferation", BIOORGANIC, ELSEVIER, AMSTERDAM, NL, vol. 11, no. 4, 1 February 2003 (2003-02-01), AMSTERDAM, NL, pages 609 - 616, XP055946468, ISSN: 0968-0896, DOI: 10.1016/S0968-0896(02)00338-3
TOBE MASANORI, ISOBE YOSHIAKI, TOMIZAWA HIDEYUKI, NAGASAKI TAKAHIRO, OBARA FUMIHIRO, HAYASHI HIDEYA: "Structure–Activity relationships of 6-fluoroquinazolines: dual-Acting compounds with inhibitory activities toward both TNF-α production and T cell proliferation", BIOORGANIC, ELSEVIER, AMSTERDAM, NL, vol. 11, no. 4, 1 February 2003 (2003-02-01), AMSTERDAM, NL, pages 609 - 616, XP055946468, ISSN: 0968-0896, DOI: 10.1016/S0968-0896(02)00338-3
Attorney, Agent or Firm:
HONESTY & JR PARTNERS INTELLECTUAL PROPERTY LAW GROUP (KR)
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