Title:
NOVEL SPIROCYCLIC K-RAS G12C INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2021/027911
Kind Code:
A1
Abstract:
The present invention relates to a spirocyclic compound and a preparation method therefor and use thereof, in particular to a compound represented by formula (1) and a preparation method therefor, and use of the compound of formula (1) and optical isomers, crystal forms, and pharmaceutically acceptable salts thereof as irreversible inhibitors of a G12C mutant K-Ras protein in the preparation of drugs for Ras-related diseases such as anti-tumor.
Inventors:
XIE YULI (CN)
FAN HOUXING (CN)
FAN HOUXING (CN)
Application Number:
PCT/CN2020/109099
Publication Date:
February 18, 2021
Filing Date:
August 14, 2020
Export Citation:
Assignee:
WIGEN BIOMEDICINE TECH SHANGHAI CO LTD (CN)
International Classes:
C07D471/10; A61K31/519; A61K31/5377; A61P35/00; A61P35/02; C07D491/20; C07D519/00
Domestic Patent References:
| WO2017201161A1 | 2017-11-23 |
Foreign References:
| US20190144444A1 | 2019-05-16 | |||
| US20180334454A1 | 2018-11-22 | |||
| US20190077801A1 | 2019-03-14 |
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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