Title:
NOVEL SULFONAMIDES AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE
Document Type and Number:
WIPO Patent Application WO2005120515
Kind Code:
A3
Abstract:
Disclosed herein are carbonyl compounds of having the structural formula (I) or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
Inventors:
MALECHA JAMES (US)
NOBLE STEWART (US)
HASSIG CHRISTIAN (US)
WASH PAUL (US)
WILEY BRANDON (US)
LAWRENCE CHARLES (US)
HOFFMAN TIMOTHY (US)
NOBLE STEWART (US)
HASSIG CHRISTIAN (US)
WASH PAUL (US)
WILEY BRANDON (US)
LAWRENCE CHARLES (US)
HOFFMAN TIMOTHY (US)
Application Number:
PCT/US2005/020770
Publication Date:
March 30, 2006
Filing Date:
June 09, 2005
Export Citation:
Assignee:
KALYPSYS INC (US)
MALECHA JAMES (US)
NOBLE STEWART (US)
HASSIG CHRISTIAN (US)
WASH PAUL (US)
WILEY BRANDON (US)
LAWRENCE CHARLES (US)
HOFFMAN TIMOTHY (US)
MALECHA JAMES (US)
NOBLE STEWART (US)
HASSIG CHRISTIAN (US)
WASH PAUL (US)
WILEY BRANDON (US)
LAWRENCE CHARLES (US)
HOFFMAN TIMOTHY (US)
International Classes:
A61K31/19; A61K31/401; A61K31/445; A61K31/55; C07C327/30; C07C329/06; C07D209/08; C07D213/70; C07D213/76; C07D231/18; C07D239/40; C07D239/42; C07D251/22; C07D261/10; C07D263/50; C07D271/07; C07D307/64; C07D333/34; C07D333/36; C07D409/12; C07D413/12; C07D417/12; C07F9/165; C07D271/06; (IPC1-7): A61K47/00; A61K31/40; A61K31/42; A61K31/505; C07C303/00; C07D209/12; C07D211/84; C07D239/02; C07D261/04
Foreign References:
| US4129656A | 1978-12-12 |
Download PDF: