NOVEL THIOUREA DERIVATIVES AS ACTIVATORS OF RORΑ AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

WIPO Patent Application WO/2012/161518

A2

The present invention relates to a novel compound for activating RORα genes, and to salts thereof. More specifically, the present invention relates to a novel JC1 compound containing CGP52608, which is a thiazolidinedione, as a lead substance, and to pharmaceutically acceptable salts of the compound. Further, the present invention relates to a lipid accumulation inhibitor comprising said novel compound as an active ingredient. The compound of the present invention is expected to be applied to the treatment of metabolic diseases or inflammatory diseases.

LEE MI OCK (KR)
PARK HYEUNG GEUN (KR)
KIM EUN JIN (KR)
SON HO YOUNG (KR)
JUNG HYO JUN (KR)
HONG SUCK CHANG (KR)
NA TAE YOUNG (KR)

PCT/KR2012/004081

November 29, 2012

May 23, 2012

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SNU R&DB FOUNDATION (KR)
LEE MI OCK (KR)
PARK HYEUNG GEUN (KR)
KIM EUN JIN (KR)
SON HO YOUNG (KR)
JUNG HYO JUN (KR)
HONG SUCK CHANG (KR)
NA TAE YOUNG (KR)

C07C335/12; A61K31/17; A61P3/06; A61P29/00

US3090810A	1963-05-21
US3949089A	1976-04-06
US3968243A	1976-07-06
US20020147365A1	2002-10-10
US20080286231A1	2008-11-20

HAN, HO GYU ET AL.: 'Synthesis of 2-Benzylimino-1,3-thiazolines and Their Structure Determination' JOURNAL OF THE KOREAN CHEMICAL SOCIETY vol. 45, 2001, pages 612 - 615
KIM, JEONGHAN ET AL.: 'Liquid Crystalline Properties of Polyguanidines' MARCROMOLECULES vol. 37, 2004, pages 8286 - 8292

ERUUM PATENT LAW FIRM (KR)
특허법인 이룸 (KR)

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