Title:
NOVEL TRIAZINE-BASED AMPHIPHILIC COMPOUND AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/075904
Kind Code:
A1
Abstract:
The present invention relates to: a newly developed triazine-based amphiphilic compound; a preparation method therefor; and a method for extracting, lysing, stabilizing, crystallizing or analyzing membrane proteins by using same. In addition, the compound, and thus enables membrane proteins, which have more various structures and characteristics than a conventional compound, to be efficiently extracted from cell membranes and stably stored in an aqueous solution for a long time, thereby being usable in functional and structural analysis thereof. Analyzing the structure and function of membrane proteins is closely related to the development of a novel drug, and thus is one of the greatest interests in the biology and chemistry fields.
More Like This:
Inventors:
CHAE PIL SEOK (KR)
GHANI LUBNA (KR)
GHANI LUBNA (KR)
Application Number:
PCT/KR2020/014159
Publication Date:
April 22, 2021
Filing Date:
October 16, 2020
Export Citation:
Assignee:
IUCF HYU ERICA CAMPUS (KR)
International Classes:
C07H17/02; C07H1/00; G01N33/68
Foreign References:
| US20130001465A1 | 2013-01-03 | |||
| US20140141034A1 | 2014-05-22 | |||
| KR20170070400A | 2017-06-22 | |||
| US20170022241A1 | 2017-01-26 |
Other References:
PIL SEOK CHAE, BAE HYOUNG EUN, EHSAN MUHAMMAD, HUSSAIN HAZRAT, KIM JIN WOONG: "New ganglio-tripod amphiphiles (TPAs) for membrane protein solubilization and stabilization: implications for detergent structure–property relationships", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 12, no. 42, 26 August 2014 (2014-08-26), pages 8480 - 8487, XP055371418, ISSN: 1477-0520, DOI: 10.1039/C4OB01375A
GHANI LUBNA, MUNK CHASTINE F., ZHANG XIANG, KATSUBE SATOSHI, DU YANG, CECCHETTI CRISTINA, HUANG WEIJIAO, BAE HYOUNG EUN, SAOUROS S: "1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, US, vol. 141, no. 50, 18 December 2019 (2019-12-18), US, pages 19677 - 19687, XP055802185, ISSN: 0002-7863, DOI: 10.1021/jacs.9b07883
GHANI LUBNA, MUNK CHASTINE F., ZHANG XIANG, KATSUBE SATOSHI, DU YANG, CECCHETTI CRISTINA, HUANG WEIJIAO, BAE HYOUNG EUN, SAOUROS S: "1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, US, vol. 141, no. 50, 18 December 2019 (2019-12-18), US, pages 19677 - 19687, XP055802185, ISSN: 0002-7863, DOI: 10.1021/jacs.9b07883
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
Download PDF: