Title:
NOVEL TRIAZINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2021/066088
Kind Code:
A1
Abstract:
Provided is a compound represented by the following formula (1) and a pharmacologically acceptable salt, which have a regulatory activity for a histamine H4 receptor and are useful for the treatment and/or prevention of diseases or conditions in which the histamine H4 receptor is involved; use of the same; and a pharmaceutical composition comprising the same.
Inventors:
FUJIWARA YUTA (JP)
ISSHIKI SATOSHI (JP)
YAMAUCHI MIKI (JP)
SUZUKI NOBUYUKI (JP)
MATSUMOTO SHOUGO (JP)
ISSHIKI SATOSHI (JP)
YAMAUCHI MIKI (JP)
SUZUKI NOBUYUKI (JP)
MATSUMOTO SHOUGO (JP)
Application Number:
PCT/JP2020/037404
Publication Date:
April 08, 2021
Filing Date:
October 01, 2020
Export Citation:
Assignee:
MEIJI SEIKA PHARMA CO LTD (JP)
International Classes:
A61P43/00; A61K31/53; A61K31/55; A61K31/551; C07D251/70; C07D401/04; C07D403/04; C07D405/14; C07D471/04; C07D471/08; C07D487/04; C07D487/08; C07D487/10
Domestic Patent References:
| WO2009035671A1 | 2009-03-19 |
Foreign References:
| US20050239827A1 | 2005-10-27 | |||
| JP2011524363A | 2011-09-01 | |||
| JP2013515698A | 2013-05-09 |
Other References:
DATABASE Registry [online] CAS; 14 May 2015 (2015-05-14), "1,3,5-Triazin-2-amine, N-phenyl-4-(1-piperazinyl)", XP055812038, retrieved from STN Database accession no. RN1704496-87-6
DATABASE Registry [online] CAS; 9 April 2019 (2019-04-09), "1,3,5-Triazin-2-amine, N-methyl-4-(1-piperazinyl)", XP055812042, retrieved from STN Database accession no. RN2303785-14-8
DATABASE Registry [online] CAS; 2 April 2019 (2019-04-02), "1,3,5-Triazin-2-amine, N-ethyl-4-(1-piperazinyl)", XP055812047, retrieved from STN Database accession no. RN 2298650-89-0
DATABASE Registry [online] CAS; 1 April 2019 (2019-04-01), "1,3,5-Triazin-2-amine, N-methyl-4-(4-methyl-1-piperazinyl)", XP055812051, retrieved from STN Database accession no. RN 2297660-70-7
DATABASE Registry [online] CAS; 15 January 2014 (2014-01-15), "1,3,5-Triazine-2,4-diamine, 6-[(1.alpha.,5.alpha.,6.alpha.)-6- [(dimethylamino)methyl]-3-azabicyclo[3.1.0]hex-3-yl]-N2-(phenylmethyl)", XP055812224, retrieved from STN Database accession no. RN 1520222-90-5
DATABASE Registry [online] CAS; 20 December 2013 (2013-12-20), "1,3,5-Triazine-2,4-diamine, 6-(1S,6R)-3,9-diazabicyclo[4.2.1]non-9-yl-N2- (phenylmethyl)", XP055812227, retrieved from STN Database accession no. RN 1500082-37-0
DATABASE Registry [online] CAS; 14 September 2011 (2011-09-14), "1,3,5-Triazine-2,4-diamine, 6-(2,7-diazaspiro[4.5]dec-2-yl)-N2- (phenylmethyl)", XP055812229, retrieved from STN Database accession no. RN 1332181-12-0
DATABASE Registry [online] CAS; 9 September 2011 (2011-09-09), "1,3,5-Triazine-2,4-diamine, 6-(1R,6S)-3,9-diazabicyclo[4.2.1]non-9-yl-N2- (phenylmethyl)-, rel-", XP055812232, retrieved from STN Database accession no. RN 1330238-02-2
DATABASE Registry [online] CAS; 9 April 2019 (2019-04-09), "1,3,5-Triazin-2-amine, N-methyl-4-(1-piperazinyl)", XP055812042, retrieved from STN Database accession no. RN2303785-14-8
DATABASE Registry [online] CAS; 2 April 2019 (2019-04-02), "1,3,5-Triazin-2-amine, N-ethyl-4-(1-piperazinyl)", XP055812047, retrieved from STN Database accession no. RN 2298650-89-0
DATABASE Registry [online] CAS; 1 April 2019 (2019-04-01), "1,3,5-Triazin-2-amine, N-methyl-4-(4-methyl-1-piperazinyl)", XP055812051, retrieved from STN Database accession no. RN 2297660-70-7
DATABASE Registry [online] CAS; 15 January 2014 (2014-01-15), "1,3,5-Triazine-2,4-diamine, 6-[(1.alpha.,5.alpha.,6.alpha.)-6- [(dimethylamino)methyl]-3-azabicyclo[3.1.0]hex-3-yl]-N2-(phenylmethyl)", XP055812224, retrieved from STN Database accession no. RN 1520222-90-5
DATABASE Registry [online] CAS; 20 December 2013 (2013-12-20), "1,3,5-Triazine-2,4-diamine, 6-(1S,6R)-3,9-diazabicyclo[4.2.1]non-9-yl-N2- (phenylmethyl)", XP055812227, retrieved from STN Database accession no. RN 1500082-37-0
DATABASE Registry [online] CAS; 14 September 2011 (2011-09-14), "1,3,5-Triazine-2,4-diamine, 6-(2,7-diazaspiro[4.5]dec-2-yl)-N2- (phenylmethyl)", XP055812229, retrieved from STN Database accession no. RN 1332181-12-0
DATABASE Registry [online] CAS; 9 September 2011 (2011-09-09), "1,3,5-Triazine-2,4-diamine, 6-(1R,6S)-3,9-diazabicyclo[4.2.1]non-9-yl-N2- (phenylmethyl)-, rel-", XP055812232, retrieved from STN Database accession no. RN 1330238-02-2
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
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