Title:
NOVEL TRIS- OR NEOPENTYL GLYCOL-BASED AMPHIPATHIC COMPOUND AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/104897
Kind Code:
A1
Abstract:
The present invention relates to a Tris- or neopentyl glycol-based amphipathic compound, a method for producing same, and a method for extracting, emulsifying, stabilizing or crystallizing a membrane protein by means of the amphipathic compound. Utilizing the Tris- or neopentyl glycol-based amphipathic compound according to the present invention allows the membrane protein to be not only effectively emulsified, but also allows stable storage in a solution for an extended period and allows the structural fluidity of the membrane protein to be easily maintained, thus said properties can be applied in the functional and structural analysis of the membrane protein. The structural and functional analysis of membrane protein is one of the areas of high interest currently in biology and chemistry, and as more than half of the new medicines currently in development target the membrane protein, the present invention can be applied to the membrane protein structure research which has a close relationship to the development of new medicine.
Inventors:
CHAE PIL SEOK (KR)
SADAF AIMAN (KR)
SADAF AIMAN (KR)
Application Number:
PCT/KR2016/002154
Publication Date:
June 22, 2017
Filing Date:
March 03, 2016
Export Citation:
Assignee:
INDUSTRY-UNIV COOP FOUND HANYANG UNIV ERICA CAMPUS (KR)
International Classes:
C07H15/04; C07C233/05; C07K1/14; C07K14/705; G01N33/68
Foreign References:
| US20130001465A1 | 2013-01-03 | |||
| US6172262B1 | 2001-01-09 |
Other References:
CHAE, P. S. ET AL.: "Glucose-neopentyl Glycol (GNG) Amphiphiles for Membrane Protein Study", CHEMICAL COMMUNICATIONS, vol. 49, no. 23, 2013, pages 2287 - 2289, XP055392183
BARTHELEMY, P. ET AL.: "Synthesis and Preliminary Assessments of Ethyl-terminated Perfluoroalkyl Nonionic Surfactants Derived from Tris (Hydroxymethyl) Acrylamidomethane", ORGANIC LETTERS, vol. 1, no. 11, 1999, pages 1689 - 1692, XP055284667, DOI: doi:10.1021/ol990558f
SADAF, A. ET AL.: "A Novel Glass of Glucose-containing Amphiphiles for Membrane Proteins Study", 15TH GENERAL MEETING OF KOREA CHEMICAL SOCIETY, 15 April 2015 (2015-04-15), pages P-736
BARTHELEMY, P. ET AL.: "Synthesis and Preliminary Assessments of Ethyl-terminated Perfluoroalkyl Nonionic Surfactants Derived from Tris (Hydroxymethyl) Acrylamidomethane", ORGANIC LETTERS, vol. 1, no. 11, 1999, pages 1689 - 1692, XP055284667, DOI: doi:10.1021/ol990558f
SADAF, A. ET AL.: "A Novel Glass of Glucose-containing Amphiphiles for Membrane Proteins Study", 15TH GENERAL MEETING OF KOREA CHEMICAL SOCIETY, 15 April 2015 (2015-04-15), pages P-736
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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