Title:
NOVEL USE OF NICOTINAMIDE MONONUCLEOTIDE (NMN) AND NICOTINAMIDE RIBOSIDE (NR)
Document Type and Number:
WIPO Patent Application WO/2020/262497
Kind Code:
A1
Abstract:
The present disclosure provides a novel use of nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR). The present disclosure provides a composition that includes nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) for treating or preventing diseases, disorders, or symptoms related to activation of Hsd3b6 or a homolog thereof, and a method using the composition. In one embodiment, a composition including NMN or NR for improving the function of meibomian glands, and a method using the composition are provided.
Inventors:
DOI MASAO (JP)
NAKAJIMA TAKESHI (JP)
MACHIDA MAMIKO (JP)
NAKAJIMA TAKESHI (JP)
MACHIDA MAMIKO (JP)
Application Number:
PCT/JP2020/024916
Publication Date:
December 30, 2020
Filing Date:
June 24, 2020
Export Citation:
Assignee:
SENJU PHARMA CO (JP)
UNIV KYOTO (JP)
UNIV KYOTO (JP)
International Classes:
A61P27/02; A61K31/706; A61P29/00
Domestic Patent References:
| WO2020054795A1 | 2020-03-19 |
Foreign References:
| US9844561B2 | 2017-12-19 | |||
| JP2018535956A | 2018-12-06 | |||
| JP2008542296A | 2008-11-27 | |||
| JP2019117642A | 2019-07-18 |
Other References:
MILLS, K.F. ET AL.: "Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice", CELL METABOLISM, vol. 24, 2016, pages 795 - 806, XP029847468, DOI: 10.1016/j.cmet.2016.09.013
SNINSKY, J. J. ET AL.: "Short Protocols in Molecular Biology: A Compendium of Methods from Current Protocols in Molecular Biology", 1999, GREENE PUB. ASSOCIATES AND WILEY-INTERSCIENCE
AUSUBEL, F. M.: "Current Protocols in Molecular Biology", 1987, GREENE PUB. ASSOCIATES AND WILEY-INTERSCIENCE
INNIS, M. A.: "PCR Protocols: A Guide to Methods and Applications", 1990, ACADEMIC PRESS
GAIT, M. J.: "Oligonucleotide Synthesis: A Practical Approach", 1985, IRL PRESS
ECKSTEIN, F.: "Oligonucleotides and Analogues: A Practical Approach", 1991, IRL PRESS
ADAMS, R. L. ET AL.: "The Biochemistry of the Nucleic Acids", 1992, CHAPMAN & HALL
SHABAROVA, Z. ET AL.: "Advanced Organic Chemistry of Nucleic Acids", 1994
BLACKBURN, G. M. ET AL.: "Nucleic Acids in Chemistry and Biology", 1996, OXFORD UNIVERSITY PRESS, article "Bioconjugate Techniques"
YODOSHA: "Experimental Methods for Transgenesis & Expression Analysis", 1997
See also references of EP 3991795A4
SNINSKY, J. J. ET AL.: "Short Protocols in Molecular Biology: A Compendium of Methods from Current Protocols in Molecular Biology", 1999, GREENE PUB. ASSOCIATES AND WILEY-INTERSCIENCE
AUSUBEL, F. M.: "Current Protocols in Molecular Biology", 1987, GREENE PUB. ASSOCIATES AND WILEY-INTERSCIENCE
INNIS, M. A.: "PCR Protocols: A Guide to Methods and Applications", 1990, ACADEMIC PRESS
GAIT, M. J.: "Oligonucleotide Synthesis: A Practical Approach", 1985, IRL PRESS
ECKSTEIN, F.: "Oligonucleotides and Analogues: A Practical Approach", 1991, IRL PRESS
ADAMS, R. L. ET AL.: "The Biochemistry of the Nucleic Acids", 1992, CHAPMAN & HALL
SHABAROVA, Z. ET AL.: "Advanced Organic Chemistry of Nucleic Acids", 1994
BLACKBURN, G. M. ET AL.: "Nucleic Acids in Chemistry and Biology", 1996, OXFORD UNIVERSITY PRESS, article "Bioconjugate Techniques"
YODOSHA: "Experimental Methods for Transgenesis & Expression Analysis", 1997
See also references of EP 3991795A4
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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