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Title:
NOVEL USE OF OREXIN RECEPTOR ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO2000047284
Kind Code:
A3
Abstract:
The use of orexin receptor antagonists as neuroprotectants, and in the treatment of nausea and vomiting, irritable bowel syndrome and other conditions associated with visceral pain.

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Inventors:
IRVING ELAINE ALISON (GB)
SANGER GARETH JOHN (GB)
Application Number:
PCT/EP2000/001147
Publication Date:
December 14, 2000
Filing Date:
February 10, 2000
Export Citation:
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Assignee:
SMITHKLINE BEECHAM PLC (GB)
IRVING ELAINE ALISON (GB)
SANGER GARETH JOHN (GB)
International Classes:
A61K31/00; A61K31/17; A61K38/00; A61P1/00; A61P1/04; A61P1/06; A61P1/08; A61P9/10; A61P13/10; A61K45/00; A61P25/06; A61P25/28; (IPC1-7): A61K31/00; A61K38/00; A61P1/08; A61P9/10; A61P13/10; A61P25/28; A61P25/06; A61P1/00
Domestic Patent References:
WO1996034877A11996-11-07
WO1999009024A11999-02-25
WO1999058533A11999-11-18
WO1999030670A21999-06-24
WO2000027845A12000-05-18
Foreign References:
EP0849361A21998-06-24
EP0875566A21998-11-04
EP0875565A21998-11-04
EP0893498A21999-01-27
Other References:
KIRCHGESSNER A L (REPRINT) ET AL: "Orexin synthesis and response in the gut", NEURON, (DEC 1999) VOL. 24, NO. 4, PP. 941-951. PUBLISHER: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138. ISSN: 0896-6273., SUNY HLTH SCI CTR, DEPT PHYSIOL & PHARMACOL, BROOKLYN, NY 11203 (Reprint);COLUMBIA UNIV COLL PHYS & SURG, DEPT ANAT & CELL BIOL, NEW YORK, NY 10032, XP000937996
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