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Title:
NRF2-ACTIVATING COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/002473
Kind Code:
A1
Abstract:
The invention addresses the problem of providing a compound having Nrf2-activation action. The invention is the compound represented by general formula (I), a salt thereof, or a solvate thereof. General formula (I): In the formula: R1a and R1b are identical or different and represent a hydrogen atom, an alkyl group, or a halogen atom; R2 represents an optionally substituted heterocycle-derived group, and the heterocycle represents thiophene, furan, pyrrole, or thiazole, or a condensed ring containing any of these heterocycles; R4 and R5 are identical or different and represent a hydrogen atom or an optionally substituted alkyl group, or R4 and R5 are bonded to one another to form -NH-CH=N-;R6 represents an optionally substituted alkyl group; A1, A2, A3, and A4 are identical or different and represent CH or N (provided that there is at most one N); and Z represents a hydrogen atom or a halogen atom.

Inventors:
MIYABE TOMOYO (JP)
MACHIDA SHINNOSUKE (JP)
OBA YUKA (JP)
Application Number:
JP2020/026309
Publication Date:
January 07, 2021
Filing Date:
July 03, 2020
Export Citation:
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Assignee:
SENJU PHARMA CO (JP)
International Classes:
C07D419/10; A61K31/554; A61P3/10; A61P27/02; A61P27/04; A61P27/06; A61P27/12; A61P43/00; C07D495/04; C07D515/04
Domestic Patent References:
WO2018109643A12018-06-21
WO2018109649A12018-06-21
Foreign References:
JP2017503786A2017-02-02
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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